Micelles formed by self-assembling of polylactide/poly(ethylene glycol) block copolymers in aqueous solutions

Liu, Yang; Zhao, Zhenxian; Wei, Jia; Ghzaoui, Abdelslam El; Li, Suming

doi:10.1016/j.jcis.2007.05.074

Cited by 81 publications

(76 citation statements)

References 37 publications

(57 reference statements)

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“…The diameter of the empty PEG-PE micelle was about 18 nm (D max ) and the diameter of its hydrophobic core was about 4.3 nm (D c ), which equals the length of two PE molecules. This result confirmed the core-shell structure of PEG-PE micelles and agreed well with a previous report [15]. Loading doxorubicin did not change the core size and the entire size of PEG-PE micelles, but loading vinorelbine increased the core size (D c ) owing to its larger molecular volume (figure 1a).…”

Section: (B) Structure Of Drug-loaded Peg-pe Micellessupporting

confidence: 93%

Cationic amphiphilic drugs self-assemble to the core–shell interface of PEGylated phospholipid micelles and stabilize micellar structure

Wang

Xing

Fang

et al. 2013

Phil. Trans. R. Soc. A.

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Since polymeric micelles are promising and have potential in drug delivery systems, people have become more interested in studying the compatibility of polymeric carriers and drugs, which might help them to simplify the preparation method and increase the micellar stability. In this article, we report that cationic amphiphilic drugs can be easily encapsulated into PEGylated phospholipid (PEG–PE) micelles by self-assembly method and that they show high encapsulation efficiency, controllable drug release and better micellar stability than empty micelles. The representative drugs are doxorubicin and vinorelbine. However, gemcitabine and topotecan are not suitable for PEG–PE micelles due to lack of positive charge or hydrophobicity. Using a series of experiments and molecular modelling, we figured out the assembly mechanism, structure and stability of drug-loaded micelles, and the location of drugs in micelles. Integrating the above information, we explain the effect of the predominant force between drugs and polymers on the assembly mechanism and drug release behaviour. Furthermore, we discuss the importance of p K a and to evaluate the compatibility of drugs with PEG–PE in self-assembly preparation method. In summary, this work provides a scientific understanding for the reasonable designing of PEG–PE micelle-based drug encapsulation and might enlighten the future study on drug–polymer compatibility for other polymeric micelles.

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Section: (B) Structure Of Drug-loaded Peg-pe Micellessupporting

confidence: 93%

Cationic amphiphilic drugs self-assemble to the core–shell interface of PEGylated phospholipid micelles and stabilize micellar structure

Wang

Xing

Fang

et al. 2013

Phil. Trans. R. Soc. A.

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“…The size of the particles is smaller than that determined by DLS in water, presumably arising from the dehydration and shrinkage of the micelles during drying in the TEM measurement. [36] As can be observed from Table 2, upon formation of polymer-platinum (II) complex nanoparticles, an increase in the particles size was seen as contrasted with the blank PCA-PCL-PCA micelle, reported previously. [28] This phenomenon can be explained by intermolecular crosslinking through the formation of -COO-Pt-OOCbridges between two different copolymer molecules [23] as illustrated in structure B of Figure 1.…”

Section: Resultssupporting

confidence: 62%

Polymer–metal complex nanoparticles-containing cisplatin and amphiphilic block copolymer for anticancer drug delivery

Gheybi

Niknejad

Entezami

2013

Designed Monomers and Polymers

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Polymer-metal complex nanoparticles-containing cisplatin (cis-dichlorodiammineplatinum(II)), an anticancer drug, was prepared by a ligand-exchange reaction of cisplatin with core-shell-type poly(citric acid)-b-poly(caprolactone)-b-poly(citric acid) (PCA-PCL-PCA). The resulting polymer-platinum complex nanoparticles showed a high loading capacity (up to 44.2% w/w). The TEM observation confirmed that the nanoparticles with spherical shape were formed by the mixing of PCA-PCL-PCA copolymer and cisplatin. According to TEM and DLS, polymer-cisplatin complex nanoparticles showed larger diameters compared with empty block copolymer attributed to some intermolecular crosslinkings through polymer-platinum (II) complex formation. The release profile of the platinum (II) complexes in phosphate-buffered saline medium at 37°C indicated sustained manner of drug release. In vitro cytotoxicity evaluated by MTT assay, demonstrated that the PCA-PCL-PCA block copolymer does not exhibit apparent cytotoxicity. PCA-PCL-PCA-cisplatin complex nanoparticles showed greater cytotoxicity to HeLa cell line contrasted with free cisplatin, attributed to existence of poly (citric acid) moiety.

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“…UV-visible [65] together with fluorescence technique [79] and surface tension [80] were the techniques mostly used in order to determine CMC values, while dynamic light scattering measurements, as a function of temperature [63,67], allowed determination of micelles size.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

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Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or packing. This property enables drugs to be mixed in the sol state at room temperature then the solution can be injected into a target tissue, forming a gel depot in-situ at body temperature with the goal of providing drug release control. The presence of micellar structures that give rise to thermoreversible gels, characterized by low toxicity and mucomimetic properties, makes this delivery system capable of solubilizing water-insoluble or poorly soluble drugs and of protecting labile molecules such as proteins and peptide drugs.

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Micelles formed by self-assembling of polylactide/poly(ethylene glycol) block copolymers in aqueous solutions

Cited by 81 publications

References 37 publications

Cationic amphiphilic drugs self-assemble to the core–shell interface of PEGylated phospholipid micelles and stabilize micellar structure

Cationic amphiphilic drugs self-assemble to the core–shell interface of PEGylated phospholipid micelles and stabilize micellar structure

Polymer–metal complex nanoparticles-containing cisplatin and amphiphilic block copolymer for anticancer drug delivery

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

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