Micelles of PAAm-<i>b</i>-PEO-<i>b</i>-PAAm Triblock Copolymers and Their Binding with Prednisolon

Zheltonozhskaya, Tatyana; Nedashkovskaya, Victoria; Khutoryanskiy, Vitaliy V.; Gomza, Yu. P.; Fedorchuk, Sergey; Klepko, V.V.; Partsevskaya, Sofia

doi:10.1080/15421406.2011.538595

Cited by 9 publications

(2 citation statements)

References 12 publications

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“…At high content of ethanol unlike to water medium, the self‐assembly of DBC macromolecules proceeds because of insolubility of PAAm blocks analogously to the behavior of PAAm‐ b ‐PEO‐ b ‐PAAm triblock copolymers at high ethanol content 15. In this case the micelles of a classical type (due to insolubility of only one block) are formed.…”

Section: Methodsmentioning

confidence: 93%

Block Copolymers of Polyacrilamide and Poly(ethylene oxide) as Nanocarriers for Drug Delivery: Micellization and Bulk Structure

Kunitskaya¹,

Zheltonozhskaya²,

Permyakova³

2012

Macromolecular Symposia

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The self-assembly of diblock copolymers series (DBC) of polyacrylamide and methoxypoly(ethylen oxide) (MOPEO-b-PAAm) with a variable length of both the blocks were studied in water and water-ethanol solutions. The tendency of DBCs to micellization in water-ethanol mixture grew with increased molecular weights of the blocks. The addition of NaCl resulted in increase of micellar stability, while the introduction of dimethylformamide (DMF) destructed DBC micelles. In DBC bulk structure, MOPEO blocks either lost or considerably reduced their ability of crystallization due to interaction with PAAm blocks. DBC micelles encapsulated anticancer drug doxorubicin (DOX) that led to lowering the crytical micellization concentration.a) The viscosity-average molecular weight of MOPEG from ''Fluka''. b) The weight fraction of MOPEO block in DBC. c) The ratio between the units in PAAm and PEO blocks.

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Section: Methodsmentioning

confidence: 93%

Block Copolymers of Polyacrilamide and Poly(ethylene oxide) as Nanocarriers for Drug Delivery: Micellization and Bulk Structure

Kunitskaya¹,

Zheltonozhskaya²,

Permyakova³

2012

Macromolecular Symposia

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“…Між тим, на кафедрі хімії мономерів і полімерів розроблено нові міцелярні наноконтейнери, які є продуктами самозбирання асиметричних блок-кополімерів з хімічно комплементарними блоками, що містять поліакриламід (ПАА) та поліетиленоксид (ПЕО) [5][6][7]. Встановлена їх висока ефективність при інкапсуляції протиракового препарату доксорубіцину [8][9][10].…”

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Behavior of Acid Hydrolysis in Block Copolymers Comprising Polyacrylamide and Poly(ethylene Oxide)

Kunitskaya

Zheltonozhskaya

2018

Bull. T. Shevchenko Nat. Univ. Kyiv. Chem.

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Polymeric micelles self-assembled from amphiphilic block copolymers have been intensively investigated as nano-carrier systems for tumor-targeted drug delivery. Diblock copolymers PEO-b-PAAm (DBC) and thriblock copolymers PAAm-b-PEO-b-PAAm (TBC) contained biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) formed micellar structures in aqueous solutions which have hydrophobic complex “core” formed by the hydrogen-bonded PEO/PAAm chains and hydrophilic “corona” of the surplus segments of PAAm blocks. The ability of DBCs and TBCs to bind the anticancer drug doxorubicin was established. This opened the new prospects for using such copolymers as nanocontainers for toxic and poorly soluble drugs. Successful implementation of DBC and TBC micelles for drug delivery requires the presence a special vectors, particularly galactose, in the micellar “corona”. Such vectors can recognize corresponding receptors on a cellular surface, interact with them, and penetrate into the intracellular space by the endocytosis pathway. In order to introduce the galactose vectors into DBC or TBC micelles, the corona forming PAA blocks have to contain the corresponding active groups, such as –OH, –COO–, –NH2. Therefore, the methods of DBCs (TBCs) functionalization are particularly important since it allows to input the necessary saccharides and also to expand the applications of micellar nanocarriers to encapsulate and delivery of both the drug substances and genetic materials. In the present work, the polymer-analogous conversion of DBCs and TBCs by the acid hydrolysis of PAAm blocks at 50°C was studied. Kinetic investigations of the hydrolysis reaction of DBCs (TBCs) in comparison with pure PAAm were performed by potentiometric titration. It was established that the process of acid hydrolysis of diblock- and thriblock copolymers depends on the blocks length and occurs more intensive in the block copolymers which have longest PEO and PAA chains. The reasons for this phenomenon are discussed. The fact is that hydrolysis of DBCs samples develops efficiently in comparison with TBCs ones attributed to the steric obstacles which appears in TBCs micelles because of their more complicated structure.

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Processes of Encapsulation and Crystallization of Prednisolon in PAAm-b-PEO-b-PAAm Micellar Solutions

Zheltonozhskaya

Partsevskaya

Горчев

et al. 2014

Molecular Crystals and Liquid Crystals

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Micelles of PAAm-b-PEO-b-PAAm Triblock Copolymers and Their Binding with Prednisolon

Cited by 9 publications

References 12 publications

Block Copolymers of Polyacrilamide and Poly(ethylene oxide) as Nanocarriers for Drug Delivery: Micellization and Bulk Structure

Block Copolymers of Polyacrilamide and Poly(ethylene oxide) as Nanocarriers for Drug Delivery: Micellization and Bulk Structure

Behavior of Acid Hydrolysis in Block Copolymers Comprising Polyacrylamide and Poly(ethylene Oxide)

Processes of Encapsulation and Crystallization of Prednisolon in PAAm-b-PEO-b-PAAm Micellar Solutions

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