Micelles with highly branched nanoporous interior: Solution properties and binding capabilities of amphiphilic copolymers with linear dendritic architecture

Gitsov, Ivan; Lambrych, Kevin R.; Remnant, Victoria A.; Pracitto, Richard

doi:10.1002/1099-0518(20000801)38:15<2711::aid-pola110>3.0.co;2-1

Cited by 101 publications

(129 citation statements)

References 65 publications

Supporting

Mentioning

126

Contrasting

Order By: Relevance

“…The organic phase was dried with magnesium sulfate and concentrated. The residue was purified by column chromatography from EtOAc/n-Hexane = 1:2 to afford the desired product 2 (1.36 g, 98% 3. NaH (55%, 68 mg, 1.55 mmol) was treated to a solution of monoproparyl-tetraethylene glycol (270 mg, 1.16 mmol) in THF (6 mL) and stirred for 1 h, followed by adding a solution of monopropargyl(tetraethylene glycol) tosylate (300 mg, 0.78 mmol) in THF (2 mL).…”

Section: Generalmentioning

confidence: 99%

Convergent Synthesis and Characterization of Dumbbell Type Dendritic Materials by Click Chemistry

Sung¹,

Han²,

Jin³

et al. 2011

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

General, fast, and efficient stitching methods for the synthesis of dendrimers with linear PEG units at a core, as dendritic-linear-dendritic materials, were developed. The synthetic strategy involved the click reaction between an alkyne and an azide. The linear core building blocks, three dialkyne-PEG units, were chosen to serve as the alkyne functionalities for dendrimer growth via click reactions with the azide-dendrons. These three building blocks were employed together with the azide-functionalized Fréchet-type dendrons in a convergent strategy to synthesize the Fréchet-type dendrimers with different linear core units. Their structure of dendrimers was confirmed by 1 H and 13 C NMR spectroscopy, IR spectroscopy, mass spectrometry, and GPC analysis.

show abstract

Section: Generalmentioning

confidence: 99%

Convergent Synthesis and Characterization of Dumbbell Type Dendritic Materials by Click Chemistry

Sung¹,

Han²,

Jin³

et al. 2011

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

show abstract

“…They are largely dependent on the chemistry, size and solvophilicity gradient between the respective blocks, and they have attracted interest due to their potential use as drug and gene delivery devices because of their ability to form micelles with critical micelle concentration (CMC) values well below the CMC values of traditional surfactants. [18][19][20] Among the numerous types of dendritic structures, polyester dendrimers are the most attractive due to their biodegradability and nontoxicity, which allows the macromolecules to degrade or hydrolyze into small nontoxic molecules for rapid exclusion from the body. 21,22 However, the utility of dendritic polymers is greatly hindered because of the tedious multistep synthesis requiring extensive purifications, and the high generation dendrimer, which are over five generation, can cause side effects due to their slow degradation, and the preparation of a dendrimer that circulates in the blood for a sufficiently long period of time to get accumulated at the target tissue is still a great challenge for most of us.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive dendritic polyrotaxane drug-polymer conjugates forming nanoparticles as efficient drug delivery system for cancer therapy

Kang

Zhang

et al. 2015

Polym. Chem.

View full text Add to dashboard Cite

a Self-assembly of stimuli-responsive polymeric nanoparticles have attracted great attention in recent years due to their prospective biological applications. This paper developed a novel pH-sensitive amphiphilic dendritic polyrotaxane drug-polymer conjugate by covalently linking doxorubicin (DOX) and dendritic polyrotaxane via a pH-responsible hydrazone bond with 1.84 wt% (weight percent) of DOX. The drugpolymer conjugate was amphiphilic and could be self-assembled to micelles (PR-g-DOX micelles) in an aqueous solution. The globular morphology and compact micelles with a diameter of around 110 nm were observed by SEM and TEM. Moreover, the micelles showed a significantly faster DOX release at mildly acidic pH of 6.0 and 5.0 and almost no burst release at the physiological pH of 7.4. Notably, it was confirmed that this micelle could efficiently deliver DOX to the nuclei of the tumor cells, which led to a much greater cytotoxic effects in the A549 cancer cells than the parent DOX. In vivo results revealed better drug tolerability of PR-g-DOX micelles and a higher in vivo efficacy without any increase in the toxicity of the PR-g-DOX micelles. Furthermore, the maximum tolerated dose (MTD) results showed that PRg-DOX micelles showed an excellent safety profile with a two-fold higher MTD (10 mg kg −1 DOX) than that of free DOX (5 mg kg −1 DOX). We are convinced that the PR-g-DOX micelle has tremendous potentials for targeted cancer therapy.

show abstract

“…[12][13][14] Typically, the micellar behavior and the morphology of such linear-dendritic copolymers have been studied with reference to dendron generation. [15][16][17][18] For example, it has been shown that critical micelle concentration (CMC) of linear-dendritic copolymers decreases with increasing generation in keeping with increasing hyrophobicity of the dendrons. [ 19,20 ] Morphology of an azo-dendron-poly(ethylene glycol) (PEG) polymer changed from nanofi bers to micelles to vesicles with increasing dendron generations.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Branching Pattern of Hydrophobic Dendrons on the Core Structure of Linear‐Dendritic Copolymer Micelles

Kalva

Aswal

Ambade

2014

Macro Chemistry & Physics

View full text Add to dashboard Cite

Hydrophobic dendrons based on different branching patterns, viz. 3,5-di-and 3,4,5-trisubstituted phenyl rings, consist of the same backbone but exhibit different sizes, shapes, and hydrophobic densities. These dendrons are attached to poly(ethylene glycol) and the core properties of the copolymer micelles are investigated in tetrahydrofuran (THF)/water mixtures by neutron scattering. Two polymers with intermediate hydrophobicity are studied further with variations in the solvent composition and the temperature. The aggregation numbers for 3,4,5-based dendron copolymers are lower, with more THF molecules of solvation compared with the 3,5-based dendron copolymer, the difference being greater at higher generations due to different molecular shapes. The micellar core size increases in small steps with dendron size so that dye encapsulation is tuned.

show abstract

Micelles with highly branched nanoporous interior: Solution properties and binding capabilities of amphiphilic copolymers with linear dendritic architecture

Cited by 101 publications

References 65 publications

Convergent Synthesis and Characterization of Dumbbell Type Dendritic Materials by Click Chemistry

Convergent Synthesis and Characterization of Dumbbell Type Dendritic Materials by Click Chemistry

pH-responsive dendritic polyrotaxane drug-polymer conjugates forming nanoparticles as efficient drug delivery system for cancer therapy

Effect of the Branching Pattern of Hydrophobic Dendrons on the Core Structure of Linear‐Dendritic Copolymer Micelles

Contact Info

Product

Resources

About