Micellization and gelation characteristics of different blends of pluronic F127/methylcellulose and their use as mucoadhesive in situ gel for periodontitis

Boonrat, Onpreeya; Tantishaiyakul, Vimon; Hirun, Namon

doi:10.1007/s00289-021-03722-w

Cited by 8 publications

(3 citation statements)

References 50 publications

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“…MC is a non-ionic, water-soluble derivative of cellulose and has the property of being thermosensitive; however, the temperature for the transition from sol to gel is approximately 60 °C when used in concentrations effective for ISGs [ 49 ]. MC also acts as a viscosity-modifying agent with mucoadhesive properties [ 50 ]. NA1 is a pH-sensitive anionic polymer of acrylic acid; although insoluble in water, it has a high swelling capacity at pH 4 to 6.…”

Section: Resultsmentioning

confidence: 99%

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

Balážová

Wolaschka

Rohaľová

et al. 2023

Life

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Silver nanoparticles (Ag NPs) with antibacterial activity can be prepared in different ways. In our case, we used ecological green synthesis with Agrimonia eupatoria L. The plant extract was used with Ag NPs for the first time to prepare termosensitive in situ gels (ISGs). Such gels are used to heal human or animal skin and mucous membranes, as they can change from a liquid to solid state after application. Ag NPs were characterized with various techniques (FTIR, TEM, size distribution, zeta potential) and their antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. In accordance with the TEM data, we prepared monodispersed spherical Ag NPs with an average size of about 20 nm. Organic active compounds from Agrimonia eupatoria L. were found on their surfaces using FTIR spectroscopy. Surprisingly, only the in situ gel with Ag NPs showed antibacterial activity against Escherichia coli, while Ag NPs alone did not. Ag NPs prepared via green synthesis using plants with medicinal properties and incorporated into ISGs have great potential for wound healing due to the antibacterial activity of Ag NPs and the dermatological activity of organic substances from plants.

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Section: Resultsmentioning

confidence: 99%

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

Balážová

Wolaschka

Rohaľová

et al. 2023

Life

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“…After 10 min, the bottles were inverted, and fluidity was observed. If the liquid showed no fluidity, it reached its CST; otherwise, the temperature was increased by 1 °C, and the process was repeated until the liquid became non-fluid [ 55 ]. The gel formation was confirmed, and changes in sample morphology were observed.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Chitosan/Hydroxypropyl Methylcellulose Temperature-Sensitive Hydrogel Containing Inorganic Salts for Forest Fire Suppression

Gao,

Zhao,

Wang

2024

Gels

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Effective forest fire suppression remains a critical challenge, necessitating innovative solutions. Temperature-sensitive hydrogels represent a promising avenue in this endeavor. Traditional firefighting methods often struggle to address forest fires efficiently while mitigating ecological harm and optimizing resource utilization. In this study, a novel intelligent temperature-sensitive hydrogel was prepared specially for forest fire extinguishment. Utilizing a one-pot synthesis approach, this material demonstrates exceptional fluidity at ambient temperatures, facilitating convenient application and transport. Upon exposure to elevated temperatures, it undergoes a phase transition to form a solid, barrier-like structure essential for containing forest fires. The incorporation of environmentally friendly phosphorus salts into the chitosan/hydroxypropyl methylcellulose gel system enhances the formation of temperature-sensitive hydrogels, thereby enhancing their structural integrity and firefighting efficacy. Morphological and thermal stability analyses elucidate the outstanding performance, with the hydrogel forming a dense carbonized layer that acts as a robust barrier against the spread of forest fires. Additionally, comprehensive evaluations employing rheological tests, cone calorimeter tests, a swelling test, and infrared thermography reveal the multifaceted roles of temperature-sensitive hydrogels in forest fire prevention and suppression strategies.

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“…With the aim to overcome poor drug retention property and prevent pain during implantation of inserts, temperature responsive in situ gelling drug delivery vehicle have been offered as a suitable alternative for local intra-pocket delivery of drug [49]. For the treatment of periodontitis, Boonrat et al [50] examined the use of mucoadhesive in situ gel by combining various proportion of pluronic F127 and methyl cellulose and proved that their designed gel formulation might have benificial effect for the recovery of periodontitis by controlling the release rate. Methyl cellulose improved the gelation property of pluronic gel by its mucoadhesive and viscosity enhancing property and as a result drug release was slowed down for prolonged period.…”

Section: Introductionmentioning

confidence: 99%

Methyl Cellulose based in situ Hydrogel for Controlled Drug Delivery and Tissue Engineering Application

DEWAN

2023

ajc

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Methyl cellulose is an attractive smart biomaterial for its thermoreversible gelation nature. When subjected to temperature stimuli, an aqueous solution containing methyl cellulose at a critical concentration exhibits the ability to form stable physically cross-linked hydrogels. These hydrogels alter the physico-chemical and mechanical properties of the methyl cellulose. This thermo-responsive nature become quite appealing when the physiological temperature functions as a trigger to regulate the thermogelation of methyl cellulose. Regarding this, exciting inventions have been explored in the drug delivery and tissue engineering field which make methyl cellulose an attractive and versatile biomaterial. In this review, we have covered traditional and advanced applications of methyl cellulose as thermoreversible in situ gelling system. Three main types of applications are presented: (i) in situ gelling system for controlled drug delivery; (ii) fabrication of injectable scaffolds and cell sheet for tissue engineering application; and finally (iii) developing methyl cellulose based bioink for 3D bioprinting by applying in situ thermogelation property of methyl cellulose.

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Micellization and gelation characteristics of different blends of pluronic F127/methylcellulose and their use as mucoadhesive in situ gel for periodontitis

Cited by 8 publications

References 50 publications

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

Preparation and Characterization of Chitosan/Hydroxypropyl Methylcellulose Temperature-Sensitive Hydrogel Containing Inorganic Salts for Forest Fire Suppression

Methyl Cellulose based in situ Hydrogel for Controlled Drug Delivery and Tissue Engineering Application

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