Micellization of Ionic Block Copolymers

Moffitt, Matthew G.; Khougaz, Karine; Eisenberg, Adi

doi:10.1021/ar940080

Cited by 360 publications

(121 citation statements)

References 61 publications

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“…In this method the ratio of intensities of bands at 333 nm and 339 nm, 339 / 333 , is plotted as function of polymer concentration (Figure 3(b)), and the CMC is identified as the breaking point [12,17]. The value of CMC obtained by this method is in the range of 10 −6 to 10 −7 M, which is quite similar to the values reported for PS 100 -b-PE4VP 100 (3 × 10 −7 M) [18] and PS 86 -b-PAA 390 CMC 1,5 × 10 −7 M [19]. These values of CMC are almost independent of the quaternization degree, which indicate that the high tendency to association at low concentration of copolymer chains is mainly due to the presence of a hydrophobic block such as polystyrene.…”

Section: Formation and Characterization Of Polymer Micelles In Aqueousupporting

confidence: 80%

Solubilization of Phenol Derivatives in Polymer Micelles Formed by Cationic Block Copolymer

Fuentes

Silva

Martínez

et al. 2017

Journal of Nanomaterials

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The aggregation of cationic block copolymers formed by polystyrene (PS) and poly(ethyl-4-vinylpyridine) (PS-b-PE4VP) was studied in aqueous solution. Diblock copolymers of PS and poly(4-vinylpyridine) were synthesized by sequential anionic polymerization using BuLi as initiator. Subsequently, the 4-vinylpyridine units were quaternized with ethyl bromide to obtain cationic PS-b-PE4VP block copolymers with different quaternization degree. The self-aggregation of cationic block copolymers was studied by fluorescence probing, whereas the morphology and size of polymer micelles were determined by transmission electronic microscopy. Results indicate that spherical micelles with sizes lower than 100 nm were formed, whereas their micropolarity decreases with increasing quaternization degree. The partition of phenols between the micellar and aqueous phase was studied by using the pseudo-phase model, and the results show that the partition coefficients increase with increasing length of the side alkyl chain and are larger for star micelles. These results are discussed in terms of three-region model.

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Section: Formation and Characterization Of Polymer Micelles In Aqueousupporting

confidence: 80%

Solubilization of Phenol Derivatives in Polymer Micelles Formed by Cationic Block Copolymer

Fuentes

Silva

Martínez

et al. 2017

Journal of Nanomaterials

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“…These structures consist of water-insoluble cores and water-soluble shells. Depending on blocks length, the core can assemble into various supramolecular structures characterized by different morphologies [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

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Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or packing. This property enables drugs to be mixed in the sol state at room temperature then the solution can be injected into a target tissue, forming a gel depot in-situ at body temperature with the goal of providing drug release control. The presence of micellar structures that give rise to thermoreversible gels, characterized by low toxicity and mucomimetic properties, makes this delivery system capable of solubilizing water-insoluble or poorly soluble drugs and of protecting labile molecules such as proteins and peptide drugs.

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“…Typical studies were focused on polystyrene-b-poly(ethylene oxide), polystyrene-b-poly(acrylic acid) and polystyrene-b-poly(methacrylic acid), etc. [8][9][10][11][12][13]. The traditional micelles are unable to sense a signal and respond by changing their structures.…”

Section: Introductionmentioning

confidence: 99%