Michelangelo's John the Baptist and thalassemia

Leonardo da Vinci’s Five Grotesque Heads: early evidence of cranio-facial mycobacterial infection

“…He was well known to follow extraordinary people around Florence to sketch their features in his notebooks, and his genius of observation, insight and artistic mastery has thus given us many of the first anatomical [1] and pathological illustrations [2]. The Five Grotesque Heads, painted in 1494 and now owned by the British Royal Collection Trust, represents one of his most well known sketches of the grotesque.…”