Micobacterias no tuberculosas. ¿Una amenaza emergente?

González, Susana; Cortés, Arantxa Cano; Yoldi, Luis Alfonso Sota; García-García, José-María; Álvarez, Lourdes Sanz; Palacios, Juan José

doi:10.1016/j.arbres.2017.02.014

Cited by 19 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results also differ from those of a recent study in Asturias, Spain, which described a 35% increase in the number of NTM isolates over a period of 8 years, although there were no changes in the number of patients with clinically significant NTM disease [12]. The only study we have found in which, as in ours, no increase was observed in the incidence of NTM was conducted in Denmark [13].…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Changing epidemiology of nontuberculous mycobacterial lung disease over the last two decades in a region of the Basque country

et al. 2019

View full text Add to dashboard Cite

Recent studies suggest an increasing prevalence of nontuberculous mycobacteria (NTM) lung disease. The aim of the present study was to describe incidence rates of NTM lung disease and trends therein in our area over a 20-year period.This was a retrospective study of all cases of NTM lung disease between 1997 and 2016 that met the 2007 American Thoracic Society criteria. We analysed the annual incidence rates, species of mycobacteria isolated, trends over time and annual mortality in 327 patients.Mycobacterium kansasii was the most common mycobacterium isolated (84%), followed by Mycobacterium avium complex (MAC) (13%). We compared two periods: 1997–2006 (257 cases, 79%) and 2007–2016 (70 cases, 21%). The incidence rates tended to decrease across these years, with a peak of incidence in 2000 with 10.6 cases per 100 000. There was a clearly decreasing trend in M. kansasii infection, not only in the first period (incident rate ratio (IRR) 0.915, 95% CI 0.88–0.90; p<0.0001) but also in the second (IRR 0.869, 95% CI 0.780–1.014; p=0.080), reaching 1.8 per 100 000 in 2016. In contrast, MAC infection tended to increase across the two periods (IRR 1.251, 95% CI 1.081–1.447; p=0.003).In our region, the incidence of NTM lung disease has notably decreased in recent years. M. kansasii had high incidence rates in the first decade but clearly decreased in the second decade.

show abstract

Section: Discussioncontrasting

confidence: 99%

“…kansasii , consistent with the findings of earlier research in Spain based on a small sample in which M. kansasii was the most commonly isolated species [22]. In contrast, in a more recent study in a region close to our study area, also coastal, the most common causative agent of NTM was MAC [12].…”

Section: Discussionsupporting

confidence: 92%

Changing epidemiology of nontuberculous mycobacterial lung disease over the last two decades in a region of the Basque country

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Hence, the escalating rate of pathogenic NTM in developing nations has been greater particularly with the advent of HIV/AIDS patients. Normally, HIV/AIDS individuals with severe immunosuppression are at high risk of NTM infections, which often cause localized or disseminated infections [50]. In addition, the failure of NTM treatment can frequently occur due to resistance to some of the available antibiotics (Table 2).…”

Section: Challenges In Diagnosing and Treatment Of Ntm Diseasesmentioning

confidence: 99%

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

2020

View full text Add to dashboard Cite

Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidrug resistance, which encompasses the classical and existing antituberculosis agents. Hence, current studies are aimed to appraise the antimycobacterial activity of flavonoids against NTM, their capacity to synergize with pharmacological agents and their ability to block virulence. Flavonoids have potential antimycobacterial effects at minor quantities by themselves or in synergistic combinations. A cocktail of flavonoids used with existing antimycobacterial agents is a strategy to lessen side effects. The present review focuses on recent studies on naturally occurring flavonoids and their antimycobacterial effects, underlying mechanisms and synergistic effects in a cocktail with traditional agents.

show abstract

“…La infección por MNT se detecta más en personas con edades avanzadas, específicamente en > 70 años, hecho objetivado previamente en múltiples trabajos [ 1 - 6 , 13 ]. Al poner el foco en el sexo, observamos que se aíslan más MNT en hombres que en mujeres, dato compartido con los de trabajos de otros autores realizados en diferentes áreas geográficas [ 1 , 6 ], pero que contrasta con los de otras zonas [ 3 - 5 , 14 ].…”

Section: Discussionunclassified

“…La especie de MNT más aislada en nuestro trabajo fue M. gordonae , lo que ya ha sido descrito previamente, no solo en trabajos de otros países europeos, sino también en otros trabajos españoles de áreas que, como la nuestra, se sitúan en la zona norte del país [ 5 , 13 ]. Tras esta especie, encontramos Mycobacterium avium complex y M. fortuitum como especies más aisladas.…”

Section: Discussionunclassified

Analysis of the incidence and epidemiology of non-tuberculous mycobacterial infections in the health area III of Aragón

Herrero¹,

Sanjoaquin²,

Lafuente³

et al. 2023

Rev Esp Quimioter

View full text Add to dashboard Cite

Objectives. The main objective of our investigation was to know the incidence and epidemiology of non-tuberculous mycobacteria (NTM) in our area and the prevalence of comorbidities in patients with MNT infection. As secondary objectives, we studied the distribution by species of MNT, the forms of disease and the type of sample used for its diagnosis. Material and methods. A retrospective study was carried out in which all the isolates of mycobacteria carried out by the microbiology laboratory of the Hospital Clínico Universitario Lozano Blesa of Zaragoza during the period between January 1, 2011 and December 31, 2018 were included. Results. A total of 533 mycobacteria were isolated, of which 295 (55.35%) were tuberculosis (MTB) and 238 (44.65%) were MNT. Of the whole MNT isolates, only 15.54% were considered clinically significant. Twenty-one species were identified being the most frequent: M. gordonae (26.89%), M. fortuitum (19.75%) and M. avium (16.39%). 32.72% of the MNT isolates were found in people over 70 years of age. Conclusions. We can confirm that the reported number of MNT isolates in our area is higher than in previous periods. MNT infection is more common in men and those older than 70 years. The epidemiology, especially the risk factors, of MNT disease is changing.

show abstract

Micobacterias no tuberculosas. ¿Una amenaza emergente?

Cited by 19 publications

References 18 publications

Changing epidemiology of nontuberculous mycobacterial lung disease over the last two decades in a region of the Basque country

Changing epidemiology of nontuberculous mycobacterial lung disease over the last two decades in a region of the Basque country

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

Analysis of the incidence and epidemiology of non-tuberculous mycobacterial infections in the health area III of Aragón

Contact Info

Product

Resources

About