2024
DOI: 10.1038/s41429-024-00731-5
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Miconazole and phenothiazine hinder the quorum sensing regulated virulence in Pseudomonas aeruginosa

Amany I. Gad,
Amira M. El-Ganiny,
Ahmed G. Eissa
et al.

Abstract: Antibiotic resistance is a major health problem worldwide. Pseudomonas aeruginosa is a Gram-negative pathogen with an arsenal of virulence factors and elevated antimicrobial resistance. It is a leading cause of nosocomial infections with high morbidity and mortality. The significant time and effort required to develop new antibiotics can be circumvented using alternative therapeutic strategies, including anti-virulence targets. This study aimed to investigate the anti-virulence activity of the FDA-approved dru… Show more

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