Miconazole-loaded nanoparticles coated with hyaluronic acid to treat vulvovaginal candidiasis

Teixeira, Aniely Dos Reis; Quaresma, Amanda V.; Branquinho, Renata Tupinambá; Santos, Stephanie Lourrani Evangelista Neves; Magalhães, Juliana Teixeira de; Silva, Fábio Henrique Rodrigues Da; Marques, Maria Betânia de Freitas; Moura, Sandra Aparecida Lima de; Barboza, Ana Paula Moreira; Araújo, Marcelo Gonzaga de Freitas; Silva, Gisele Rodrigues Da

doi:10.1016/j.ejps.2023.106508

Cited by 5 publications

(1 citation statement)

References 36 publications

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“…The imidazole group’s wide-spectrum antifungal drug MCZ is frequently used to treat oral candidiasis, an opportunistic fungal infection of the oral cavity brought on by an overabundance of Candida species [ 1 ]. Of them, the most common species found in oral cavity isolates from both healthy and sick people is Candida albicans .…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Namazi,

Alrbyawi,

Alanezi

et al. 2024

Pharmaceutics

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The objective of this research was to develop a mucoadhesive delivery system that improves permeation for the administration of poorly absorbed oral medications. Thiolation of xanthan gum (XGM) was carried out by esterification with mercaptobutyric acid. Fourier-transformed infrared spectroscopy was used to confirm thiol-derivatization. Using Ellman’s technique, it was revealed that the xanthan-mercaptobutyric acid conjugate had 4.7 mM of thiol groups in 2 mg/mL of polymeric solution. Using mucosa of sheep intestine, the mucoadhesive properties of XGM and thiolated xanthan gum (TXGM) nanoparticles were investigated and we found that TXGM had a longer bioadhesion time than XGM. The disulfide link that forms between mucus and thiolated XGM explains why it has better mucoadhesive properties than XGM. A study on in vitro miconazole (MCZ) release using phosphate buffer (pH 6.8) found that TXGM nanoparticles released MCZ more steadily than MCZ dispersion did. A 1-fold increase in the permeation of MCZ was observed from nanoparticles using albino rat intestine compared to MCZ. Albino rats were used to test the pharmacokinetics of MCZ, and the results showed a 4.5-fold increase in bioavailability. In conclusion, the thiolation of XGM enhances its bioavailability, controlled release of MCZ for a long period of time, and mucoadhesive activity.

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Section: Introductionmentioning

confidence: 99%