Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study

Potential plants for inflammatory dysfunction in the SARS-CoV-2 infection

“…Among the major anti-inflammatory mechanisms involved in clinical studies with selected plants, the following stand out: decrease in CRP levels (Rondanelli et al 2020 ; Viecili et al 2014 ; Somanah et al 2012 ; Miranda-Vilela et al 2009 ; Kim et al 2018 ; Panza et al 2019 ; Talsma et al 2016 ; Inoue et al 2008 ; Kitada et al 2017 ; Kaspar et al 2011 ; Solà et al 2012 ; Stote et al 2012 ; Monagas et al 2009 ); cytokines and pro-inflammatory markers such as: IL-6 (Buchwald-Werner et al 2018 ; Stockler-Pinto et al 2014 ; Colpo et al 2014 ; Santamarina et al 2020 ; Panza et al 2019 ; Kitada et al 2017 ; Li et al 2013 ; Alayón et al 2019 ; Manzoni et al 2017 ; Kaspar et al 2011 ; Stote et al 2012 ; Davis et al 2020 ), TNF-α (Stockler-Pinto et al 2014 ; Colpo et al 2014 ; Santamarina et al 2020 ; Kim et al 2018 ; Panza et al 2019 ; George et al 2019 ; Decha et al 2019 ; Piscoya et al 2001 ), IFN-γ (Colpo et al 2014 ; Kim et al 2018 ; George et al 2019 ), IL-1 (Colpo et al 2014 ; Davis et al 2020 ), IL-8 (Inoue et al 2008 ), IL-18 (Davis et al 2020 ), MCP-1 (Santamarina et al 2020 ), ICAM-1 (Monagas et al 2009 ); increased cytokine level and anti-inflammatory modulator IL-10 (Colpo et al 2014 ; Santamarina et al 2020 ; Manzoni et al 2017 ) and FGF-19 (Jokioja et al 2020 ); inhibition of NF-κB pathway (Li et al 2013 ); decreased oxidative markers (TBARS, ROS, NO, 8-OHdG, dROM) (Miranda-Vilela et al 2009 ; Inoue et al 2008 ; Gomes et al 2021 ; Kitada et al 2017 ; Decha et al 2019 ; Davis et al…”

“…Consumption of yellow cassava increased serum β-carotene concentration by 524% and led to modest gains in serum retinol concentrations Randomized Controlled Trial (NCT01614483) (Talsma et al 2016 ) Myrciaria dubia (Kunth) McVaugh — Myrtaceae (Amazon) Daily 70 ml of 100% camu-camu juice, corresponding to 1050 mg of vitamin C (camu-camu group; n = 10) for 7 days In 20 male smoking volunteers, considered to have an accelerated oxidative stress state, oxidative stress markers such as the levels of urinary 8-hydroxy-deoxyguanosine (8-OHdG) (9.0 to 7.0 ng/mg) and total reactive oxygen species (ROS) (128 to 123 Unit) and inflammatory markers such as serum levels of hs-CRP (0.05 to 0.02 mg/dL), interleukin IL-6 (6.0 to 5.1 pg/mL), and IL-8 (24.8 to 22.4 pg/mL) decreased significantly in the camu-camu group, suggesting that camu-camu juice may have powerful anti-oxidative and anti-inflammatory properties, that may be due to the existence of unknown anti-oxidant substances besides vitamin C Randomized Controlled Trial (Inoue et al 2008 ) Miconia albicans (Sw.) Steud. — Melastomataceae (tropical and temperate regions of South America) M. albicans (1000 mg/day) was applied orally for 30 days In Twenty-four osteoarthritis patients, means of Osteoarthritis Index Total (WOMAC) for M. albicans presented a statistically significant difference (mean day 0 = 57.19; mean day 30 = 31.02), demonstrating the analgesic and anti-inflammatory effect on knee osteoarthritis from M. albicans Clinical Trial (Gomes et al 2021 ) Passiflora edulis Sims — Passifloraceae (Brazil) Piceatannol compound from P. edulis , (20 mg/day) for eight weeks On 39 subjects, including 10 overweight men and 9 overweight women (BMI ≥ 25), as well as 10 non-overweight men and 10 non-overweight women (BMI < 25), piceatannol in womans decreased hs-CRP levels (ng/mL) (Start: 212.6 ± 233.1; 8 week: 117.6 ± 56.9), IL-6 (Start: 1.50 ± 0.41; 8 week: 1.32 ± 0.38), diacron reactive oxygen metabolite (dROM) (U. Carr) (Start: 354.2 ± 37.8; 8 week: 308.6 ± 30.7), biological antioxidant potential (BAP) (Start: 486.8 ± 182.9; 8 week: 2120.0 ± 207.7), and in men decreased Flow Mediated Dilation (FMD) (%) (Start: 6.6 ± 4.8; 8 week: 8.4 ± 2.7). Supplementation can improve metabolic health Randomized, Placebo, Controlled Trial (Kitada et al 2017 ) Persea americana Mill.…”

The Genus Miconia Ruiz & Pav. (Melastomataceae): Ethnomedicinal Uses, Pharmacology, and Phytochemistry

“…According to Correa et al [13], the methanolic extract of M. minutiflora leaves showed anti-inflammatory effects, thus inhibiting edema and the recruitment of leukocytes to the inflamed auricular tissue of mice. Gomes et al [6] observed in their studies that M. albicans showed analgesic and anti-inflammatory effects in the treatment of patients with knee osteoarthritis, thus decreasing the pain of patients, an effect comparable to the pharmaceutical drug ibuprofen.…”

“…Gomes et al [6] found that the aqueous extract of M. chamissois showed antimicrobial activity against C. albicans and S. aureus, having an MIC of 78.1 µg/mL and 312.5 µg/mL, respectively, but did not show activity against E. coli.…”

“…Miconia has round 1900 species; in Brazil, 289 species of this genus are found, among which, 42% are endemic, distributed in different phytogeographic domains (Amazon, Caatinga, Cerrado, and Atlantic Forest) [6]. Members of this genus are used in the treatment of health conditions such as pain [7], throat conditions [8], and fever and cold symptoms [9,10], as well as a depurative, diuretic, and sedative [11]; some studies have already cited its popular uses [12,13].…”