Micosis fungoide folicular. Estudio de cuatro casos

Gómez-Díez, Santiago; Maldonado, Carmen; Fueyo, A.; Vázquez‐López, Francisco; Fresno, Manuel; Pérez‐Oliva, Narciso

doi:10.1016/s0001-7310(07)70113-8

Cited by 8 publications

(2 citation statements)

References 23 publications

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“…Presentations include follicular erythematous papules, plaques, cysts, and comedone-like lesions. [6] Alopecia is common and can be seen in up to 65% of the cases. [78] Two cases in our series showed these features.…”

Section: Discussionmentioning

confidence: 99%

Follicular mycosis fungoides - A report of four Indian cases

Rajalakshmi

Inchara

Antony

2009

Indian J Med Paediatr Oncol

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Background:Follicular Mycosis Fungoides (FMF) is an under-recognized disease in India. Its clinical mimics include Hansen’s disease and Sarcoidosis.Aims:To describe the clinical and pathological features of FMF.Materials and Methods:All cases of FMF between January and December 2007 were retrieved. Cases of conventional epidermotropic MF with a minor follicular component were excluded. Slides were reviewed by two observers. The following criteria were assessed: degree and density of folliculotropism of lymphocytes, location of folliculotropism (infundibular / isthmic / bulbar), follicular mucin, eosinophils, granulomas, and conventional epidermotropism. Each feature was assigned a semi-quantitative grade.Results:There were four cases of FMF, with an equal gender distribution and a mean age of 17.5 years. All lesions were on the face. They presented as: hypopigmented patches (2) and erythematous plaques (2). Alopecia was seen in two cases. The clinical diagnosis was Hansen’s disease in all four, with a differential of Alopecia mucinosa / Sarcoidosis in two cases.The histological features seen were: disproportionate folliculotropism, lymphocyte tagging with haloes, follicular mucin, and nucleomegaly / convolution in all four cases, prominent eosinophils (2), epithelioid granulomas (1), eccrine infiltration (4), parakeratosis at the follicular ostia (2), and sebaceotropism (1). The infiltrate was bulbar (4) and isthmic (2). The rest of the epidermis showed no hint of conventional MF.Conclusion:The preferential features for FMF were involvement of face, dominant folliculotropism, nuclear atypia and convolution, and follicular mucin. Presence of granulomas and eosinophils necessitated exclusion of infectious causes. The absence of findings of MF in the rest of the epidermis should not deter pathologists from rendering this diagnosis.

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Section: Discussionmentioning

confidence: 99%

Follicular mycosis fungoides - A report of four Indian cases

Rajalakshmi

Inchara

Antony

2009

Indian J Med Paediatr Oncol

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“…Therefore, in cases with slight follicular involvement, findings of eccrine gland involvement could be helpful in the diagnosis3. According to the few studies reported on patients with folliculotropic MF, the percentage of accompanying eccrine gland involvement is 4% to 33% (Table 1)3,4,5,6,7,8,9,10. It is unclear whether folliculotropism or syringotropism is a function of specific cell-surface antigens of the T-cells, adhesion molecules, or an abnormality of follicular or syringeal epithelium2.…”

Section: Discussionmentioning

confidence: 99%

Two Clinically Unusual Cases of Folliculotropic Mycosis Fungoides: One with and the Other without Syringotropism

et al. 2014

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Mycosis fungoides is the most common form of cutaneous T-cell lymphoma, and it rarely exhibits predilection for hair follicle and eccrine gland infiltration. Here, we present 2 similar cases that display folliculotropism with varying amounts of follicular mucinosis, with and without syringotropism. The features observed in both cases were cystic, comedo-like, acneiform lesions; generalized involvement with loss of body hair; pruritus; and hidradenitis suppurativa-like lesions. Hypohidrosis as well as nail and palmoplantar involvement with lichen planopilaris-like clinical features were unique characteristics of the first case. Despite the well-known aggressive behavior of follicular mycosis fungoides, the presented cases had a subtle, slowly progressive, but persistent, clinical course. Folliculotropic and syringotropic mycosis fungoides are variants of cutaneous T-cell lymphoma. Clinical presentations might be challenging, and multiple, deep biopsy specimens containing adnexal structures are required for this critical diagnosis. Aggressive treatment may not be necessary in cases having an indolent course, especially in those with syringotropism.

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