Micro and nano-fabrication of biodegradable polymers for drug delivery

Lu, Yi; Chen, S.C.

doi:10.1016/j.addr.2004.05.002

Cited by 296 publications

(174 citation statements)

References 42 publications

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“…The fabrication of advanced drug delivery systems (DDSs) is increasingly 72 dependent on the creation of complex architectures and understanding 73 structure-activity relationships at the nanoscale [1][2][3]. To this end, core-shell 74 nanostructures have been very widely studied in the production of functional 75 nanomaterials, including those for biomedical applications [4][5][6].…”

Section: Introduction 71mentioning

confidence: 99%

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process

et al. 2016

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Section: Introduction 71mentioning

confidence: 99%

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process

et al. 2016

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“…In addition, dextran possesses multiple hydroxyls which are convenient for chemical modification to endow polymersome surfaces with various desired functions such as drug-targeting and diagnostic recognition. In addition, poly(ε-caprolactone) (PCL) was chosen as the hydrophobic block of the amphiphilic copolymer for its well demonstrated biocompatibility, biodegradability, and wide utilization as a drug delivery material [24,25]. However, there are limited studies regarding block copolymers with dextran as hydrophilic segment so far.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and self-assembly behavior of amphiphilic diblock copolymer dextran-block-poly(ε-caprolactone) (DEX-b-PCL) in aqueous media

Zhang¹,

Dou²,

Jin³

2010

Express Polym. Lett.

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Abstract. An amphiphilic diblock copolymer, dextran-block-poly(ε-caprolactone) (DEX-b-PCL), with a series of welldefined chain lengths of each block was prepared by conjugating a dextran chain with a PCL block via aza-Michael addition reaction under mild conditions. For the dextran block, samples with relatively uniform molecular weight, 3.5 and 6.0 kDa, were used, and the PCL blocks were prepared via ring-opening polymerization at defined ratios of ε-caprolactone to initiator in order to give copolymers with mass fraction of dextran (fDEX) ranging from 0.16 to 0.45. When these copolymers were allowed to self-assemble in aqueous solution, the morphology of assembled aggregates varied as a function of fDEX when characterized by transmission electron microscope (TEM), fluorescence microscope (FM) and dynamic laser scattering (DLS). As fDEX decreases gradually from 0.45 to 0.16, the morphology of the copolymer assembly changes from spherical micelles to worm-like micelles and eventually to polymersomes, together with an increase in particle sizes.

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“…Both polymers have been approved by FDA for drug delivery (Jain et al, 1998;Södergård and Stolt, 2002;Panyam and Labhasetwar, 2003) and widely used as excipients in nanoprecipitation processes (Jain, 2000;Lu and Chen, 2004). The main objectives of this study were: (i) to make appropriate choice of good and poor solvent of the polymers, (ii) to observe the mixing process in situ using a microscope video system, and (iii) to investigate the effect of operating parameters, system geometry, and surfactants on the final particle size distribution.…”

Section: Introductionmentioning

confidence: 99%

Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

Othman

Vladisavljević

Nagy

2015

Chemical Engineering Science

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The aim of this study was to develop a new microfluidic approach for the preparation of nanoparticles with tuneable sizes based on micromixing / direct nanoprecipitation in a coaxial assembly of tapered-end glass capillaries. The organic phase was 1 wt% poly(-caprolactone) (PCL) or poly(dl-lactic acid) (PLA) in tetrahydrofuran and the antisolvent was Milli-Q water.The size of nanoparticles was precisely controlled over a range of 190-650 nm by controlling phase flow rates, orifice size and flow configuration (two-phase co-flow or countercurrent flow focusing). Smaller particles were produced in a flow focusing device, because the organic phase stream was significantly narrower than the orifice and remained narrow for a longer distance downstream of the orifice. The mean size of PCL particles produced in a flow focusing device with an orifice size of 200 m, an organic phase flow rate of 1.7 mL h -1 and an aqueous-toorganic flow rate ratio of 10 was below 200 nm. The size of nanoparticles decreased with decreasing the orifice size and increasing the aqueous-to-organic phase flow rate ratio. Due to *Revised Manuscript Click here to view linked References 2 higher affinity for water and amorphous structure, PLA nanoparticles were smaller and exhibited a smoother surface and more rounded shape than PCL particles.

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Micro and nano-fabrication of biodegradable polymers for drug delivery

Cited by 296 publications

References 42 publications

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process

Synthesis and self-assembly behavior of amphiphilic diblock copolymer dextran-block-poly(ε-caprolactone) (DEX-b-PCL) in aqueous media

Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

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