Micro-arc oxidation as a tool to develop multifunctional calcium-rich surfaces for dental implant applications

Ribeiro, Ana R.; Oliveira, F.; Boldrini, Leonardo C.; Leite, Paulo Emílio Corrêa; Falagan-Lotsch, Priscila; Linhares, Adriana; Zambuzzi, Willian Fernando; Fragneaud, Benjamin; Campos, Andréa; Gouvêa, C.P.; Archanjo, Bráulio S.; Achete, Carlos A.; Marcantônio, Élcio; Rocha, L. A.; Granjeiro, José Mauro

doi:10.1016/j.msec.2015.05.012

Cited by 93 publications

(80 citation statements)

References 60 publications

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“…Several studies had shown that MAO treatment on Ti surfaces enhanced its biological response. Alves et al performed PEO on commercial pure Ti and studied the biological properties of Ca‐and P‐enriched layers assessed for osteoblastic cell viability/proliferation ability.…”

Section: Introductionmentioning

confidence: 99%

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

et al. 2018

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Highly porous Ti implant materials are being used in order to overcome the stress shielding effect on orthopedic implants. However, the lack of bioactivity on Ti surfaces is still a major concern regarding the osseointegration process. It is known that the rapid recruitment of osteoblasts in bone defects is an essential prerequisite for efficient bone repair. Conventionally, osteoblast recruitment to bone defects and subsequent bone repair has been achieved using growth factors. Thus, in this study highly porous Ti samples were processed by powder metallurgy using space holder technique followed by the bio-functionalization through microarc oxidation using a Ca- and P-rich electrolyte. The biological response in terms of early cell response, namely, adhesion, spreading, viability, and proliferation of the novel biofunctionalized highly porous Ti was carried out with NIH/3T3 fibroblasts and MC3T3-E1 preosteoblasts in terms of viability, adhesion, proliferation, and alkaline phosphatase activity. Results showed that bio-functionalization did not affect the cell viability. However, bio-functionalized highly porous Ti (22% porosity) enhanced the cell proliferation and activity. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

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Section: Introductionmentioning

confidence: 99%

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

et al. 2018

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“…17 These functions are closely related to the physiological function of Ca 2+ . On one hand, Ca 2+ activates osteoblast membrane-bound receptors and starts the osteoblast signalling pathway.…”

Section: Phase Analysis Of the Mao Coatingsmentioning

confidence: 99%

“…Ribeiro et al fabricated oxide Ca/P-doped coatings on Ti surfaces using MAO; the coating was shown to be the main factor leading to faster osteoblast adhesion and spreading and also promoted higher amounts of IFN-γ cytokine secretion in vitro. 17 Bai et al prepared similar Ca/P-rich coatings on Ti via a combination of MAO and electrophoretic deposition. These coatings showed good biological activity in vitro.…”

Section: Surface Morphologies Of the Mao Coatingsmentioning

confidence: 99%

Surface modification of biomedical tantalum by micro-arc oxidation

Zhao

Yang

et al. 2016

Materials Technology

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Tantalum (Ta) is well known for its excellent workability, fatigue resistance and fracture toughness. However, it does not show bone-bonding ability (i.e. bioactivity). In the present work, porous Ta-oxide films incorporating calcium (Ca) and phosphorus (P) were prepared on pure Ta by micro-arc oxidation (MAO) in an electrolyte containing calcium glycerophosphate and calcium acetate. Film morphology, composition and phase were investigated using scanning electron microscopy, energy dispersive spectroscopy and X-ray diffraction, respectively. The surface topography and roughness of the films were investigated by atomic force microscopy operated in tapping mode. The results showed that the surfaces of the coatings exhibited typical porous and rough structures typical of MAO. Ca and P were successfully incorporated into the MAO coatings, and their concentrations could be controlled by adjusting the MAO parameters. The formation of the MAO coatings endowed Ta with potential bioactivity, and the resulting films may be promising candidates for implants.

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“…Plasma electrolytic oxidation (PEO) is an appropriate method with which to produce oxide layers on titanium alloys [8]. Carried out in electrolytes containing calcium and phosphorous compounds in appropriate forms (ions or fine dispersions), the PEO process can be employed for the formation of bioactive coatings.…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Electrolyte Nature and PEO Process Parameters on Properties of Anodized Ti-15Mo Alloy Intended for Biomedical Applications

Banakh¹,

Snizhko²,

Journot³

et al. 2018

Metals

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Plasma electrolytic oxidation (PEO) of Ti-15Mo alloys conducted in electrolytes containing Ca and P compounds can be an efficient process with which to obtain bioactive coatings. This paper reports on the influence of the nature of the electrolyte, its concentration, and PEO process parameters on the properties of anodized layers on Ti-15Mo. A wide range of Ca-and P-containing alkaline and acidic solutions was employed to incorporate Ca and P ions into the anodized layer. The efficiency of the incorporation was evaluated by the Ca/P ratio in the coating as compared to that in the electrolyte. It was found that alkaline solutions are not suitable electrolytes for the formation of good quality, uniform PEO coatings. Only acidic electrolytes are appropriate for obtaining well-adherent homogeneous layers on Ti-15Mo. However, the maximum Ca/P ratios reached in the coatings were rather low (close to 1). The variation of electrical signal (negative-to-positive current ratio, frequency) and time of electrolysis do not result in a substantial change of this value. The processing time, however, did influence the coating thickness. Despite their low Ca/P ratio, the anodized layers demonstrate good biological activity, comparable to pure microrough titanium.

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Micro-arc oxidation as a tool to develop multifunctional calcium-rich surfaces for dental implant applications

Cited by 93 publications

References 60 publications

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

Surface modification of biomedical tantalum by micro-arc oxidation

The Influence of the Electrolyte Nature and PEO Process Parameters on Properties of Anodized Ti-15Mo Alloy Intended for Biomedical Applications

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