Micro-Computed Tomography—Current Status and Developments

Ritman, Erik L.

doi:10.1146/annurev.bioeng.6.040803.140130

Cited by 333 publications

(241 citation statements)

References 83 publications

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“…However, it could be complemented by determining the anatomy of the intact olfactory organ by magnetic resonance imaging (Anon. 2006;Pohlmann et al 2007) and X-ray microtomography ( Flannery et al 1987;Ritman 2004), and these data used to generate real and virtual three-dimensional models for flow visualization (see below). For comparative purposes, it would be helpful if weights and lengths of fishes were routinely included in any anatomical descriptions.…”

Section: Future Directionsmentioning

confidence: 99%

Hydrodynamic aspects of fish olfaction

Cox

2008

J. R. Soc. Interface.

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Flow into and around the olfactory chamber of a fish determines how odorant from the fish's immediate environment is transported to the sensory surface (olfactory epithelium) lining the chamber. Diffusion times in water are long, even over comparatively short distances (millimetres). Therefore, transport from the external environment to the olfactory epithelium must be controlled by processes that rely on convection (i.e. the bulk flow of fluid). These include the beating of cilia lining the olfactory chamber and the relatively inexpensive pumping action of accessory sacs. Flow through the chamber may also be induced by an external flow. Flow over the olfactory epithelium appears to be laminar. Odorant transfer to the olfactory epithelium may be facilitated in several ways: if the olfactory organs are mounted on stalks that penetrate the boundary layer; by the steep velocity gradients generated by beating cilia; by devices that deflect flow into the olfactory chamber; by parallel arrays of olfactory lamellae; by mechanical agitation of the chamber (or olfactory stalks); and by vortices. Overall, however, our knowledge of the hydrodynamics of fish olfaction is far from complete. Several areas of future research are outlined.

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Section: Future Directionsmentioning

confidence: 99%

Hydrodynamic aspects of fish olfaction

Cox

2008

J. R. Soc. Interface.

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“…The data conferred under the above section were obtained by combining confocal laser scanning- [9,22] , live cell- [23] , atomic force- [24] , scanning electron- [10,17] and transmission electron [16,25] microscopy data. In line, we started up correlative confocal laser scanning microscopy- [9,18] and X-ray microcomputed tomography (CT) [26] studies as defined above to quantitatively collect the spatial and temporal cell-and tissue architecture at different resolution levels of CRC hepatic metastasis (vide infra).…”

Section: R E C O N S T R U C T I N G a N D M O D E L I N G Colorectalmentioning

confidence: 99%

The hepatic sinusoidal endothelial lining and colorectal liver metastases

Braet¹,

Nagatsuma²,

Saito³

et al. 2007

WJG

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Colorectal cancer (CRC) is a common malignant disease and the severe nature of cases in men and women who develop colorectal cancer makes this an important socio-economic health issue. Major challenges such as understanding and modeling colorectal cancer pathways rely on our understanding of simple models such as outlined in this paper. We discuss that the development of novel standardized approaches of multidimensional (correlative) biomolecular microscopy methods facilitates the collection of (sub) cellular tissue information in the early onset of colorectal liver metastasis and that this approach will be crucial in designing new effective strategies for CRC treatment. The application of X-ray micro-computed tomography and its potential in correlative imaging of the liver vasculature will be discussed.

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“…This setup achieves a better mechanical stability which is required at high resolutions. An exception on the rotating sample are in-vivo small animal micro-CT scanners (Ritman, 2004;Schuster et al, 2004). These are usually designed for high-speed scanning at reduced M A N U S C R I P T…”

Section: Typical Micro-ct Setupmentioning

confidence: 99%

High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications

Cnudde

Boone

2013

Earth-Science Reviews

1,263

700

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Please cite this article as: Cnudde, V., Boone, M.N., "High-resolution X-ray computed tomography in geosciences: a review of the current technology and applications", Earth Science Reviews (2013Reviews ( ), doi: 10.1016Reviews ( /j.earscirev.2013 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T AbstractHigh-resolution X-ray Computed Tomography (HRXCT) or micro-CT (µCT) is a frequently used non-destructive 3D imaging and analysis technique for the investigation of internal structures of a large variety of objects, including geomaterials. Although the possibilities of X-ray micro-CT are becoming better appreciated in earth science research, the demands on this technique are also approaching certain physical limitations. As such, there remains a lot of research to be done in order to solve all the technical problems that occur when higher demands are put on the technique. In this paper, a review of the principle, the advantages and limitations of X-ray CT itself are presented, together with an overview of some current applications of micro-CT in geosciences. One of the main advantages of this technique is the fact that it is a non-destructive characterization technique which allows 4D monitoring of internal structural changes at resolutions down to a few hundred nanometers. Limitations of this technique are the operator dependency for the 3D image analysis from the reconstructed data, the discretations effects and possible imaging artefacts. Driven by the technological and computational progress, the technique is continuously growing as an analysis tool in geosciences and is becoming one of the standard techniques, as is shown by the large and still increasing number of publications in this research area. It is foreseen that this number will continue to rise, and micro-CT will become an indispensable technique in the field of geosciences.

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Micro-Computed Tomography—Current Status and Developments

Cited by 333 publications

References 83 publications

Hydrodynamic aspects of fish olfaction

Hydrodynamic aspects of fish olfaction

The hepatic sinusoidal endothelial lining and colorectal liver metastases

High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications

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