Micro-CT Imaging with a Hepatocyte-selective Contrast Agent for Detecting Liver Metastasis in Living Mice

Kim, Hye Won; Cai, Quanyu; Jun, Hong Yeoung; Chon, Kwon Su; Park, Seung Hoon; Byun, Seung Jae; Lee, Myung Soo; Oh, Jae Min; Kim, Hun Soo; Yoon, Kwon‐Ha

doi:10.1016/j.acra.2008.03.021

Cited by 21 publications

(17 citation statements)

References 16 publications

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“…Other examples of microCT imaging systems are manufactured by General Electric Medical Systems (model RS-9, London, Ontario) (12), volumetric CT scanner (NFR-Polaris-G90; NanoFocusRay, Iksan, Korea) [12] used for detection of liver metastases and flat-panel volumetric computed tomography (fpVCT) [13]. …”

Section: Description Of Methodsmentioning

confidence: 99%

In vivo micro-CT imaging of liver lesions in small animal models

Martiniova

Schimel

Lai

et al. 2010

Methods

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Three-dimensional micro-computed tomography (microCT) offers the opportunity to capture images liver structures and lesions in mice with a high spatial resolution. Non-invasive microCT allows for accurate calculation of vessel tortuosity and density, as well as liver lesion volume and distribution. Longitudinal monitoring of liver lesions is also possible. However, distinguishing liver lesions from variations within a normal liver is impossible by microCT without the use of liver-or tumor-specific contrast-enhancing agents. The combination of microCT for morphologic imaging with functional imaging, such as positron emission tomography (PET) or single photon emission tomography (SPECT), offers the opportunity for better abdominal imaging and assessment of structure discrepancies visible by functional imaging.This manuscript describes methods of current microCT imaging options for imaging of liver lesions compared to other imaging techniques in small animals.

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Section: Description Of Methodsmentioning

confidence: 99%

In vivo micro-CT imaging of liver lesions in small animal models

Martiniova

Schimel

Lai

et al. 2010

Methods

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“…Microcomputerized tomography (CT) has also successfully been used to detect metastases in mice. Using a hepatocyte-selective contrast agent and micro-CT, liver metastases established after injecting colon adenocarcinoma cells into the portal vein of mice could be detected (Kim et al, 2008). MR and CT are generally anatomic techniques for detection of metastases in vivo.…”

Section: Approaches Currently Used To Detect Metastatic Lesions (Omentioning

confidence: 99%

Detecting Tumor Metastases

Menezes

Das

Minn

et al. 2016

Advances in Cancer Research

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Metastasis is the complex process by which primary tumor cells migrate and establish secondary tumors in an adjacent or distant location in the body. Early detection of metastatic disease and effective therapeutic options for targeting these detected metastases remain impediments to effectively treating patients with advanced cancers. If metastatic lesions are identified early, patients might maximally benefit from effective early therapeutic interventions. Further, monitoring patients whose primary tumors are effectively treated for potential metastatic disease onset is also highly valuable. Finally, patients with metastatic disease can be monitored for efficacy of specific therapeutic interventions through effective metastatic detection techniques. Thus, being able to detect and visualize metastatic lesions is key and provides potential to greatly improve overall patient outcomes. In order to achieve these objectives, researchers have endeavored to mechanistically define the steps involved in the metastatic process as well as ways to effectively detect metastatic progression. We presently overview various preclinical and clinical in vitro and in vivo assays developed to more efficiently detect tumor metastases, which provides the foundation for developing more effective therapies for this invariably fatal component of the cancerous process.

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“…61 Although technically challenging, imaging of metastatic lesions is arguably the most important task for molecular imaging of cancer because patient mortality is often linked to dissemination of malignant tissue, rather than prolonged residence in an inopportune site. 61,62 Small-animal CT, 63 MR, 64 US, 65 PET, 66 SPECT-CT, 67 and bioluminescence 67 imaging have been adapted for imaging in preclinical metastatic models.…”

Section: Preclinical Imaging Tools and Disease Modelsmentioning

confidence: 99%