2021
DOI: 10.21203/rs.3.rs-916636/v1
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Micro-Fourier-Transform Infrared Reflectance Spectroscopy as Tool for Probing IgG Glycosylation in COVID-19 Patients

Abstract: It has been reported that patients diagnosed with COVID-19 become critically ill primarily around the time of activation of the adaptive immune response. However the role of antibodies in the worsening of disease is not obvious. Higher titers of anti-spike immunoglobulin IgG1 associated to low fucosylation of the antibody Fc tail have been associated to excessive inflammatory response. In contrast it has been also reported in literature that NP-, S-, RBD- specific IgA, IgG, IgM are not associated with SARS-CoV… Show more

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“…To investigate the correlation between antibody response and SARS-CoV-2 infection, serum samples of adult healthcare workers (asymptomatic or mild) infected with COVID-19 and healthy people were detected by Micro-Fourier transform infrared spectroscopy (Micro-FTIR). In Bandeira's study, Micro-FTIR was used to study serum samples from healthy and COVID-19 (mild or minimally synthetic) individuals (Bandeira, 2022). And the specificity was 87.5% and the true positive detection rate was 100% as shown in Figure 2E.…”
Section: Ftir Spectroscopy Sensorsmentioning
confidence: 99%
“…To investigate the correlation between antibody response and SARS-CoV-2 infection, serum samples of adult healthcare workers (asymptomatic or mild) infected with COVID-19 and healthy people were detected by Micro-Fourier transform infrared spectroscopy (Micro-FTIR). In Bandeira's study, Micro-FTIR was used to study serum samples from healthy and COVID-19 (mild or minimally synthetic) individuals (Bandeira, 2022). And the specificity was 87.5% and the true positive detection rate was 100% as shown in Figure 2E.…”
Section: Ftir Spectroscopy Sensorsmentioning
confidence: 99%