Micro‐lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer

Ikeguchi, Masahide; Fukuda, Kenji; Oka, Shinichi; Hisamitsu, Kazunori; Katano, Kuniyuki; Tsujitani, Shunichi; Kaibara, Nobuaki

doi:10.1002/jso.1093

Cited by 18 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In early gastric cancer, cathepsin D activates micro-lymph node metastasis [67], and studies have shown that human telomerase reverse transcriptase (hTERT) can stimulate cathepsin D expression by activating early growth response protein 1 (an important nuclear transcription factor that can promote cell proliferation), thereby inducing cancer cell invasion [68]. Anterior gradient 2 (AGR2), a p53 suppressor that is widely expressed in many tumors, is known to stimulate the proliferation and development of cancer cells.…”

Section: Gastric Cancermentioning

confidence: 99%

Cathepsins in digestive cancers

et al. 2017

View full text Add to dashboard Cite

Cathepsins are lysosomal peptidases belonging to the papain family, and based on their catalytic sites, these enzymes can be divided into serine, cysteine and aspartic proteases. The studies conducted to date have identified, 15 types of cathepsins that are widely distributed in intracellular and extracellular spaces. These proteases participate in various pathological activities, including the occurrence and development of human cancers. Several recent studies suggest that cathepsins, particularly cathepsins B, D, E and L, contribute to digestive tumorigenesis. Cathepsins were found to promote the development of most digestive cancers except liver cancer, in which they might have the opposite effects. Due to their important roles in digestive tumors, cathepsins might be therapeutic targets for the treatment of digestive cancers.

show abstract

Section: Gastric Cancermentioning

confidence: 99%

Cathepsins in digestive cancers

et al. 2017

View full text Add to dashboard Cite

show abstract

“…[1][2][3] Occult metastasis at the time of operation is an important cause of cancer recurrence. Another possibility leading to cancer recurrence is the fact that surgical manipulation may spread cancer cells from the main tumor into a patient's blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Detection of Circulating Cancer Cells After a Gastrectomy for Gastric Cancer

Ikeguchi

Kaibara

2005

Surg Today

Self Cite

View full text Add to dashboard Cite

show abstract

“…15,23,24 Subsequently, it has been recommended that levels of CD be monitored as a prognostic indicator in breast cancer and used independent of classical prognostic parameters such as tumor size, histological grade, lymph node status, and steroid receptor expression. 25 -27 The significance of pCD and CD levels in other tumors such as endometrial adenocarcinoma, 28,29 colon carcinoma, 30 colorectal carcinoma, 31 oral cancer, 32 laryngeal tumors, 33,34 head and neck squamous cell carcinoma, 35 carcinoma of thyroid tissue, 36 prostate tumors 37,38 melanoma, 8,39 gastric cancer, 40 and ovarian cancer, 41,42 has also been demonstrated, suggesting that this system might be involved in the metastatic growth of numerous other cancer cell types.…”

mentioning

confidence: 99%

Procathepsin D in breast cancer: What do we know? Effects of ribozymes and other inhibitors

2002

View full text Add to dashboard Cite

Procathepsin D (pCD) is a major secreted glycoprotein in some human breast and other cancer cell lines. Several groups proposed that pCD served as a growth factor for these cell lines. Secreted pCD has been demonstrated in tissue section, tissue culture supernatants, carcinoma cytosols, and nipple aspirates. Moreover, several clinical studies suggested a potential role for this molecule in metastasis because its concentration in primary tumors correlated with an increased incidence of tumor metastases. In this paper, the effects of pCD were evaluated by proliferation in vitro and by mouse studies in vivo. Subsequent flow cytometry experiments showed the specificity of pCD binding to cancer cells. Cell cultivation showed that addition of either pCD or its activation peptide stimulates growth of cancer cells. These effects can be inhibited both in vitro and in vivo by anti-pCD antibodies. In addition, production of pCD can be inhibited by specifically designed ribozymes. This paper is focused on mitogenic effects of pCD, which seem to involve interaction of the activation peptide with as yet unidentified receptor. Different mechanisms by which pCD could promote development and spread of cancer cells are discussed.

show abstract

Micro‐lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer

Abstract: The acidic protease CD may play an important role of cancer metastasis in EGC. The limited operation without lymphadenectomy should be indicated for EGC with CD-negative.

Cited by 18 publications

References 29 publications

Cathepsins in digestive cancers

Cathepsins in digestive cancers

Detection of Circulating Cancer Cells After a Gastrectomy for Gastric Cancer

Procathepsin D in breast cancer: What do we know? Effects of ribozymes and other inhibitors

Contact Info

Product

Resources

About