Micro-/nano-fluidic devices and <i>in vivo</i> fluorescence imaging based on quantum dots for cytologic diagnosis

Luo, Minchuan; Yukawa, Hiroshi; Baba, Yoshinobu

doi:10.1039/d2lc00113f

Cited by 19 publications

(11 citation statements)

References 91 publications

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“…Currently, Nano-carriers containing near-infrared region (NIR) foreign chromophores are being researched as the specific and sensitive optical imaging probes. [49] Relevant researches show that the reduction of inherent background interference, relatively deep optical penetration, and significant improvement of molecular and morphological contrast can be realized by this kind of nanoplatform. [50] GNRs with outstanding surface plasma resonance (SPR) properties, can absorb and scatter light in special wavelength.…”

Section: Nir Fluorescence Imagingmentioning

confidence: 99%

Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy

Ma,

Li,

Ying

et al. 2024

ChemMedChem

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For unique surface plasmon absorption and fluorescence characteristics, gold nanorods have been developed and widely employed in the biomedical field. However, limitations still exist due their low specific surface area, instability and tendency agglomerate in cytoplasm. Mesoporous silica materials have been broadly applied in field of catalysts, adsorbents, nanoreactors, and drug carriers due to its unique mesoporous structure, highly comparative surface area, good stability and biocompatibility. Therefore, coating gold nanorods with a dendritic mesopore channels can effectively prevent particle agglomeration, while increasing the specific surface area and drug loading efficiency. This review discusses the advancements of GNR@MSN in synthetic process, bio‐imaging technique and tumor therapy. Additionally, the further application of GNR@MSN in imaging‐guided treatment modalities is explored, while its promising superior application prospect is highlighted. Finally, the issues related to in vivo studies are critically examined for facilitating the transition of this promising nanoplatform into clinical trials.

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Section: Nir Fluorescence Imagingmentioning

confidence: 99%

Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy

Ma,

Li,

Ying

et al. 2024

ChemMedChem

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“…Fluorescence-based assays for the analysis of tumor cell biomarkers are more responsive than electrochemical assays 74 . In addition to the detection of extracellular tumor markers in body fluids using fluorescent biosensors, the in situ detection of intracellular tumor biomarkers in living cells by combining fluorescence analysis with nanodevices is also gaining attention 75 . The following section summarizes the analytical methods for fluorescence detection of intra- and extracellular tumor biomarkers in recent years.…”

Section: Fluorescence Sensingmentioning

confidence: 99%

Current research status of tumor cell biomarker detection

Jiang,

Lin,

Chen

et al. 2023

Microsyst Nanoeng

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With the annual increases in the morbidity and mortality rates of tumors, the use of biomarkers for early diagnosis and real-time monitoring of tumor cells is of great importance. Biomarkers used for tumor cell detection in body fluids include circulating tumor cells, nucleic acids, protein markers, and extracellular vesicles. Among them, circulating tumor cells, circulating tumor DNA, and exosomes have high potential for the prediction, diagnosis, and prognosis of tumor diseases due to the large amount of valuable information on tumor characteristics and evolution; in addition, in situ monitoring of telomerase and miRNA in living cells has been the topic of extensive research to understand tumor development in real time. Various techniques, such as enzyme-linked immunosorbent assays, immunoblotting, and mass spectrometry, have been widely used for the detection of these markers. Among them, the detection of tumor cell markers in body fluids based on electrochemical biosensors and fluorescence signal analysis is highly preferred because of its high sensitivity, rapid detection and portable operation. Herein, we summarize recent research progress in the detection of tumor cell biomarkers in body fluids using electrochemical and fluorescence biosensors, outline the current research status of in situ fluorescence monitoring and the analysis of tumor markers in living cells, and discuss the technical challenges for their practical clinical application to provide a reference for the development of new tumor marker detection methods.

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“…The linear range of fluorescence quenching was detected in the region from 2.0 to 15.0 µg/mL, and 0.73 µg/mL is the lowest amount that can be used to measure it. Moreover, targeted fluorescence imaging in vitro and in vivo demonstrated the capability to specifically detect EGFR [ 21 ]. Zong et al developed ternary nanocomposite based on MOF-derived zinc oxide nanopolyhedra/GQDs/polyaniline via an in situ polymerization technique [ 99 ].…”

Section: Sensing Application Of Quantum/polymer Compositementioning

confidence: 99%

“…Additionally, due to their biocompatibility, CDs have been investigated as a potential green alternative to heavy metal-containing conventional semiconductor QDs. Simple preparation, a wide range of precursors, strong hydrophilicity, great sensitivity and selectivity, adjustable surface and fluorescence characteristics, minimal cytotoxicity, outstanding electron transport capability, and chemical inertness are just some of QDs’ many benefits [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Progression of Quantum Dots Confined Polymeric Systems for Sensorics

et al. 2023

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The substantial fluorescence (FL) capabilities, exceptional photophysical qualities, and long-term colloidal stability of quantum dots (QDs) have aroused a lot of interest in recent years. QDs have strong and wide optical absorption, good chemical stability, quick transfer characteristics, and facile customization. Adding polymeric materials to QDs improves their effectiveness. QDs/polymer hybrids have implications in sensors, photonics, transistors, pharmaceutical transport, and other domains. There are a great number of review articles available online discussing the creation of CDs and their many uses. There are certain review papers that can be found online that describe the creation of composites as well as their many different uses. For QDs/polymer hybrids, the emission spectra were nearly equal to those of QDs, indicating that the optical characteristics of QDs were substantially preserved. They performed well as biochemical and biophysical detectors/sensors for a variety of targets because of their FL quenching efficacy. This article concludes by discussing the difficulties that still need to be overcome as well as the outlook for the future of QDs/polymer hybrids.

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Micro-/nano-fluidic devices and in vivo fluorescence imaging based on quantum dots for cytologic diagnosis

Abstract: Semiconductor quantum dots (QDs) possess attractive merits over traditional organic dyes such as tunable emission, narrow emission spectra and good resistance against optical bleaching, which plays a vital role in...

Cited by 19 publications

References 91 publications

Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy

Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy

Current research status of tumor cell biomarker detection

Progression of Quantum Dots Confined Polymeric Systems for Sensorics

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