Micro/nanofabricated platforms for oral drug delivery

Fox, Cade B.; Kim, Jean; Le, Long V.; Nemeth, Cameron L.; Chirra, Hariharasudhan D.; Desai, Tejal A.

doi:10.1016/j.jconrel.2015.07.033

Cited by 96 publications

(81 citation statements)

References 171 publications

(201 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent study 17 , we demonstrated that covering the entire surface of porous titanium biomaterials with TiO 2 nano-tubes could lead to up-regulation of osteogenic markers in vitro and significantly improved biomechanical performance in vivo. Other researchers have found similar effects not only for nano-tubular surfaces [18][19] but also for surfaces covered with other types of nano-topographical features [20][21] .…”

Section: Introductionsupporting

confidence: 56%

Antibacterial Behavior of Additively Manufactured Porous Titanium with Nanotubular Surfaces Releasing Silver Ions

Yavari

Loozen

Paganelli

et al. 2016

ACS Appl. Mater. Interfaces

138

117

View full text Add to dashboard Cite

Additive manufacturing (3D printing) has enabled fabrication of geometrically complex and fully interconnected porous biomaterials with huge surface areas that could be used for biofunctionalization to achieve multifunctional biomaterials. Covering the huge surface area of such porous titanium with nanotubes has been already shown to result in improved bone regeneration performance and implant fixation. In this study, we loaded TiO2 nanotubes with silver antimicrobial agents to equip them with an additional biofunctionality, i.e., antimicrobial behavior. An optimized anodizing protocol was used to create nanotubes on the entire surface area of direct metal printed porous titanium scaffolds. The nanotubes were then loaded by soaking them in three different concentrations (i.e., 0.02, 0.1, and 0.5 M) of AgNO3 solution. The antimicrobial behavior and cell viability of the developed biomaterials were assessed. As far as the early time points (i.e., up to 1 day) are concerned, the biomaterials were found to be extremely effective in preventing biofilm formation and decreasing the number of planktonic bacteria particularly for the middle and high concentrations of silver ions. Interestingly, nanotubes not loaded with antimicrobial agents also showed significantly smaller numbers of adherent bacteria at day 1, which may be attributed to the bactericidal effect of high aspect ratio nanotopographies. The specimens with the highest concentrations of antimicrobial agents adversely affected cell viability at day 1, but this effect is expected to decrease or disappear in the following days as the rate of release of silver ions was observed to markedly decrease within the next few days. The antimicrobial effects of the biomaterials, particularly the ones with the middle and high concentrations of antimicrobial agents, continued until 2 weeks. The potency of the developed biomaterials in decreasing the number of planktonic bacteria and hindering the formation of biofilms make them promising candidates for combating peri-operative implant-associated infections.

show abstract

Section: Introductionsupporting

confidence: 56%

Antibacterial Behavior of Additively Manufactured Porous Titanium with Nanotubular Surfaces Releasing Silver Ions

Yavari

Loozen

Paganelli

et al. 2016

ACS Appl. Mater. Interfaces

138

117

View full text Add to dashboard Cite

show abstract

“…[12] Specifically, the nanowires disrupted the tight junctions, the major determinant of paracellular permeability. For a more in-depth review on platforms for oral drug delivery, see Fox et al [13]. …”

Section: Transepithelial Deliverymentioning

confidence: 99%

Nanotopography applications in drug delivery

Walsh

Allen

Desai

2015

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

Refinement of micro- and nanofabrication in the semiconductor field has led to innovations in biomedical technologies. Nanotopography, in particular, shows great potential in facilitating drug delivery. The flexibility of fabrication techniques has created a diverse array of topographies that have been developed for drug delivery applications. Nanowires and nanostraws deliver drug cytosolically for in vitro and ex vivo applications. In vivo drug delivery is limited by the barrier function of the epithelium. Nanowires on microspheres increase adhesion and residence time for oral drug delivery, while also increasing permeability of the epithelium. Low aspect ratio nanocolumns increase paracellular permeability, and in conjunction with microneedles increase transdermal drug delivery of biologics in vivo. In summary, nanotopography is a versatile tool for drug delivery. It can deliver directly to cells or be used for in vivo delivery across epithelial barriers. This editorial highlights the application of nanotopography in the field of drug delivery.

show abstract

“…Unfortunately, approximately 50% of active pharmaceutical agents are estimated to have limited oral bioavailability due to low solubility, low membrane permeability, and rapid degradation [2,3]. Oral dosages should be designed to protect drugs from the harsh environment of the gastrointestinal (GI) tract and maximize drug uptake and absorption in the cellular intestinal regions.…”

Section: Introductionmentioning

confidence: 99%