Micro/nanosystems for controllable drug delivery to the brain

Recent advances in targeted drug delivery for the treatment of glioblastoma

“…Advanced multimodal cross-scale imaging technologies, such as multi-SIM, ultra-high field MRI, and fast scanning PA, can provide technical support for real-time localization of drug delivery carriers. 209 It is necessary to develop drug delivery carriers with dual functions of imaging and therapy. For instance, swimming nanorobots propelled by external magnetic fields exhibit excellent magnetic resonance imaging capabilities, enabling real-time monitoring of their movement toward tumor lesions.…”

Emerging Perspectives on Prime Editor Delivery to the Brain

“…The BBB forms the core of the neurovascular unit (NUV) and consists of brain microvessel endothelial cells, extracellular matrix, pericytes, and astrocytes. The NUV is the system responsible for the selective permeability of BBB (Figure 3) [82,85]. Understanding the full extent of the impact of the BBB on drug delivery to the CNS, especially to the brain, has been a long-standing challenge that persists today.…”

“…The brain is protected by complex and finely regulated biological barriers that prevent harmful substances from entering the brain. These barriers include the blood–brain barrier (BBB), blood–cerebrospinal fluid barrier (BCSFB), and arachnoid barrier [ 82 ]. These three layers act to restrict and control the movement of molecules at the interfaces between blood and neural tissue or its fluid spaces protecting the brain from potentially harmful substances [ 83 ].…”

“…The BBB forms the core of the neurovascular unit (NUV) and consists of brain microvessel endothelial cells, extracellular matrix, pericytes, and astrocytes. The NUV is the system responsible for the selective permeability of BBB ( Figure 3 ) [ 82 , 85 ].…”

Enhancing autonomous navigation: acoustic tomography through synthetic data modeling

“…It is even more exposed in places where traditional support methods fail, for example, the use of navigation aids such as GPS [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] and many other advanced control [46][47][48][49][50] and estimation methods [51][52][53][54][55][56]. Acoustic tomography as a tool comes to limelight when a certain place is not viewable optically either because it is deep as in the case of the underwater environment or it is crowded as in the densely obstructed area [57][58][59][60][61][62][63]. Compared to the conventional approach, coupled with synthetic data modeling-which brings forth artificial data sets based on the simulated scenarios-, this method can be of great importance in terms of precision, steadiness, adaptability, and automotive navigation systems.…”