2022
DOI: 10.1039/d2cc03713k
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Micro-photo-flow reactor system for fused N-heteroaryl scaffold synthesis and late-stage functionalization of pyrazolopyridines

Abstract: Late-stage functionalization (LSF) of active pharmaceutical ingredients can provide a straightforward approach to efficient de-novo design and synthesis of the drug molecule for the structural activity relationship studies (SARS). Herein,...

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Cited by 4 publications
(2 citation statements)
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“…S4, ESI †) and commer-cialized liquid-liquid separator to exchange the solvent (ESI section S4.1 †). [43][44][45] After slight modification of the extraction and separation conditions, the extraction time and separation time were found to be 0.66 min and 0.66 min, respectively (Table S3, entry 5, ESI †). Furthermore, to test the long-term stability of the developed integrated system (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…S4, ESI †) and commer-cialized liquid-liquid separator to exchange the solvent (ESI section S4.1 †). [43][44][45] After slight modification of the extraction and separation conditions, the extraction time and separation time were found to be 0.66 min and 0.66 min, respectively (Table S3, entry 5, ESI †). Furthermore, to test the long-term stability of the developed integrated system (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…S4, ESI†) and commercialized liquid–liquid separator to exchange the solvent (ESI section S4.1†). 43–45…”
Section: Resultsmentioning
confidence: 99%