Micro-porous polyetheretherketone implants decorated with BMP-2 via phosphorylated gelatin coating for enhancing cell adhesion and osteogenic differentiation

Wu, Jiu-Ping; Li, Linlong; Fu, Chen; Yang, Fan; Zhang, Jiao; Shi, Xincui; Ito, Yoshihiro; Wang, Zongliang; Liu, Qinyi; Zhang, Peibiao

doi:10.1016/j.colsurfb.2018.05.027

Cited by 66 publications

(52 citation statements)

References 37 publications

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“…The hydroxylation of PEEK lms was achieved according to the protocol reported by the literature. 24 In brief, DMSO had been distilled to remove water and oxygen prior to use. DMSO (70 mL) and sodium borohydride (140 mg) were introduced in a 150 mL round bottomed ask equipped with reux condenser and heated at 120 C under stirring until dissolution occurred.…”

Section: Hydroxylation On Peek Surface (Peek-oh)mentioning

confidence: 99%

Covalently functionalized poly(etheretherketone) implants with osteogenic growth peptide (OGP) to improve osteogenesis activity

Yakufu

Wang

et al. 2020

RSC Adv.

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Section: Hydroxylation On Peek Surface (Peek-oh)mentioning

confidence: 99%

Covalently functionalized poly(etheretherketone) implants with osteogenic growth peptide (OGP) to improve osteogenesis activity

Yakufu

Wang

et al. 2020

RSC Adv.

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“…Covalent anchoring of BMPs and BMP‐peptides provides another approach that avoids the burst release often seen with coated molecules and instead offers sustained activity without detrimental side effects . Significant increases in the osteogenic differentiation of MC3T3‐E1 cells, pull‐out strength, and bone growth around PEEK implants were observed with immobilized BMP‐2 on a collagen intermediate coating after 8 weeks in a New Zealand white rabbit disk replacement model; this demonstrates how covalent attachment can help retain the bioactivity of BMP‐2 for a longer period of time .…”

Section: Strategies For Improving Osseointegrationmentioning

confidence: 86%

“…Hydroxylation of PEEK is accomplished by reducing the carbonyl groups on the PEEK backbone to hydroxyl groups with sodium borohydride (NaBH 4 ) in dimethylsulfoxide (DMSO) at elevated temperatures . This technique has been used to create reactive hydroxyl groups on PEEK for subsequent chemical modifications, such as silanization or phosphorylation …”

Section: Surface Modification Techniquesmentioning

confidence: 99%

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

Buck

Cerruti

2019

Macromolecular Bioscience

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In the last 5 years, a wide variety of surface modification strategies are explored to improve the integration of poly(etheretherketone) (PEEK) implants with bone. Since PEEK does not support bone on‐growth, its surface properties need to be tailored to promote osteogenesis at the bone‐implant interface. Surface modifications applied to achieve this response range from simple surface morphology changes to the deposition of osteoconductive coatings. Of the many methods, titanium and/or hydroxyapatite coatings, extrusion to create surface pores, and an accelerated neutral atom beam treatment have been approved by the U.S. Food and Drug Administration to improve the integration of PEEK spinal cages. The success of these surface modifications brings hope for the clinical translation of other techniques in the future, but there are several limitations that may be preventing other treatments from reaching the clinic. This review describes numerous strategies that have been applied to PEEK‐based implants for improving their osseointegration and enhancing their antibacterial properties. The review concludes with a discussion about future directions for the field and provides suggestions for advancing clinical translation of surface‐modified PEEK implants to improve the lives of patients in need of these implants.

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“…For this reason, one of the polymers that promises to be efficient as a multifunctional material in the design of filters of air purification equipments is polyetheretherketone (PEEK). This semicrystalline thermoplastic polymer formed by an aromatic chain, combines ketone and ether functional groups between the aryl rings with a mechanical strength stable at high temperatures and resistance to most inorganic and organic substances in comparison with other polymers derived from the polyaryletherketone family (PAEK) [8][9][10]. These characteristics make PEEK an ideal material for various applications such as components in filters for air decontamination and as complements in decontaminating systems, using effective coatings based on silver nanoparticles with high activity in low concentrations [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Coating of Polyetheretherketone Films with Silver Nanoparticles by a Simple Chemical Reduction Method and Their Antibacterial Activity

et al. 2019

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The coating of polymeric substrate polyetheretherketone (PEEK) with silver nanoparticles (AgNPs) was carried out by a wet chemical route at room temperature. The coating process was developed from the Tollens reagent and D-glucose as reducing agent. The resulting composite exhibited antimicrobial activity. The PEEK films were coated with a single layer and two layers of silver nanoparticles in various concentrations. The crystallographic properties of the polymer and the silver nanoparticles were analyzed by X-ray diffraction (XRD). Fourier transform infrared spectra (FTIR) show the interaction between the silver nanoparticles with the polymeric substrate. Transmission electron microscope (TEM) images confirmed the obtaining of metallic nanoparticles with average sizes of 25 nm. It was possible to estimate the amount of silver deposited on PEEK with the help of thermogravimetric analysis. The morphology and shape of the AgNPs uniformly deposited on the PEEK films was ascertained by the techniques of scanning electron microscopy (SEM) and atomic force microscopy (AFM), evidencing the increase in the amount of silver by increasing the concentration of the metal precursor. Finally, the antibacterial activity of the films coated with Ag in Escherichia coli, Serratia marcescens and Bacillus licheniformis was evaluated, evidencing that the concentration of silver is crucial in the cellular replication of the bacteria.

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Micro-porous polyetheretherketone implants decorated with BMP-2 via phosphorylated gelatin coating for enhancing cell adhesion and osteogenic differentiation

Cited by 66 publications

References 37 publications

Covalently functionalized poly(etheretherketone) implants with osteogenic growth peptide (OGP) to improve osteogenesis activity

Covalently functionalized poly(etheretherketone) implants with osteogenic growth peptide (OGP) to improve osteogenesis activity

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

Coating of Polyetheretherketone Films with Silver Nanoparticles by a Simple Chemical Reduction Method and Their Antibacterial Activity

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