Micro RNA -214,-150,-146a and-125b target<i>Huntingtin</i>gene

Sinha, Mithun; Ghose, Jayeeta; Bhattarcharyya, Nitai P.

doi:10.4161/rna.8.6.16035

Cited by 76 publications

(60 citation statements)

References 47 publications

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“…[4,5]). Several miRNAs viz, miR-214, -150, À146a, and À125b [6] miR-137, miR-214 and miR148a [7] have been shown to target HTT gene. Expression of HTT has been shown to decrease in HD models [6], human post mortem brain [8] and fibroblasts of HD patients [9].…”

Section: Introductionmentioning

confidence: 99%

Regulation of mitochondrial morphology and cell cycle by microRNA-214 targeting Mitofusin2

Bucha

Mukhopadhyay

Bhattacharyya

2015

Biochemical and Biophysical Research Communications

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Section: Introductionmentioning

confidence: 99%

Regulation of mitochondrial morphology and cell cycle by microRNA-214 targeting Mitofusin2

Bucha

Mukhopadhyay

Bhattacharyya

2015

Biochemical and Biophysical Research Communications

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“…Several miRNAs were shown to target the Htt mRNA. A direct interaction between the 3 0 UTR of Htt mRNA and miRNAs, including the autophagy-related miR-125b, was reported [116]. miR-125b could downregulate Htt levels in cells.…”

Section: Huntington's Disease and Autophagy Mirnasmentioning

confidence: 96%

Alteration in Autophagic-lysosomal Potential During Aging and Neurological Diseases: The microRNA Perspective

2013

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Macroautophagy (hereafter referred to as autophagy) is an evolutionary conserved degradation pathway that targets cytoplasmic substrates, including long-lived proteins, protein aggregates and damaged organelles, and leads to their degradation in lysosomes. Beyond its role in adaptation to cellular stresses, such as nutrient deprivation, hypoxia and toxins, recent studies attributed a central role to autophagy in aging and life span determination. Moreover, alterations and abnormalities of autophagy may contribute to a number of important health problems, including cancer, myopathies, metabolic disorders and, the focus of this review, aging-related neurodegenerative diseases. Some disease-related, mutant and aggregation-prone proteins may be cleared by autophagy; on the other hand, disregulation of the autophagy pathways may also contribute to neurotoxicity observed in degenerative pathologies. microRNAs (miRNAs) are endogenous regulators of gene expression, and their deregulation was reported in several aging-related conditions. Studies in the last few years introduced miRNAs as novel and potent regulators of autophagy. In this review article, we will summarize the connection between autophagy, aging and Alzheimer's, Parkinson's and Huntington's diseases, and discuss the role of autophagy-related miRNAs in this context.

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“…MicroRNAs regulate genes that are involved in the production or clearance of pathological structures [136][137][138][139]. This includes genes involved in the production or modification of β-amyloid or tau, which form amyloid plaques and neurofibrillary tangles seen in Alzheimer's disease brains [136] as well as genes involved in regulating the expression and aberrant accumulation of α-synuclein, a pathological feature of Parkinson's disease [137,138].…”

Section: Neurodegenerative Diseasementioning

confidence: 99%

“…This includes genes involved in the production or modification of β-amyloid or tau, which form amyloid plaques and neurofibrillary tangles seen in Alzheimer's disease brains [136] as well as genes involved in regulating the expression and aberrant accumulation of α-synuclein, a pathological feature of Parkinson's disease [137,138]. Several microRNAs have been identified that altered expression of the huntingtin gene, thereby regulating huntingtin aggregation in Huntington's disease [139]. Neurodegenerative disorders are characterized by a progressive spreading of this neuropathology.…”

Section: Neurodegenerative Diseasementioning

confidence: 99%

Extracellular microRNAs as messengers in the central and peripheral nervous system

Scott

2017

Neuronal Signaling

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Correspondence : Hannah Scott (ScottH5@cardiff.ac.uk) MicroRNAs are small post-transcriptional regulators that play an important role in nervous system development, function and disease. More recently, microRNAs have been detected extracellularly and circulating in blood and other body fluids, where they are protected from degradation by encapsulation in vesicles, such as exosomes, or by association with proteins. These microRNAs are thought to be released from cells selectively through active processes and taken up by specific target cells within the same or in remote tissues where they are able to exert their repressive function. These characteristics make extracellular microRNAs ideal candidates for intercellular communication over short and long distances. This review aims to explore the potential mechanisms underlying microRNA communication within the nervous system and between the nervous system and other tissues. The suggested roles of extracellular microRNAs in the healthy and the diseased nervous system will be reviewed.

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Micro RNA -214,-150,-146a and-125b targetHuntingtingene

Cited by 76 publications

References 47 publications

Regulation of mitochondrial morphology and cell cycle by microRNA-214 targeting Mitofusin2

Regulation of mitochondrial morphology and cell cycle by microRNA-214 targeting Mitofusin2

Alteration in Autophagic-lysosomal Potential During Aging and Neurological Diseases: The microRNA Perspective

Extracellular microRNAs as messengers in the central and peripheral nervous system

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