Micro-scale Dynamic Simulation of Erythrocyte–Platelet Interaction in Blood Flow

Al-Momani, Thakir D.; Udaykumar, H. S.; Marshall, J.S.; Chandran, K. B.

doi:10.1007/s10439-008-9478-z

Cited by 92 publications

(84 citation statements)

References 44 publications

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“…A higher hematocrit can improve margination of platelets closer to the vessel wall where hemostasis normally occurs after tissue injury. 36 Recent experimental evidence also suggests that RBCs are essential in forming an impermeable complex polyhedral structure blood clot to optimize hemostasis. 37,38 Although maintaining a higher hematocrit may be beneficial for patients with active critical bleeding requiring massive transfusion, the side effects and complications of allogeneic RBC transfusions are also amplified in this setting.…”

Section: Evidence From Observational and Experimental Studiesmentioning

confidence: 99%

Context-dependent risks and benefits of transfusion in the critically ill

Harahsheh¹,

Ho²

2017

IJCTM

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Transfusion of red blood cells (RBCs) and other blood products to critically ill patients is common. Blood products are expensive, and not without risks. Recent evidence from high-quality multicenter randomized controlled trials confirmed the safety of allogeneic RBC transfusions, including the use of aged RBCs, and mild to moderate anemia for most stable and nonbleeding critically ill patients. Emerging evidence suggests that a liberal RBC transfusion target may have potential divergent effects on patient outcomes depending on their clinical context, with possible harms for patients with gastrointestinal bleeding due to portal hypertension and, conversely, benefits for patients with severe underlying cardiovascular diseases. Despite an apparent increased risk of bleeding in critically ill patients with deranged coagulation parameters and thrombocytopenia, recent studies suggested that fresh frozen plasma (FFP) and platelet transfusions may not be beneficial and, indeed, also not very effective in correcting these abnormalities. As for patients who have active severe critical bleeding, use of empirical 1:1:1 RBC: platelets: FFP transfusion appears justifiable in an attempt to reduce deaths as a result of exsanguination. In conjunction with platelet count and fibrinogen concentration, whole blood viscoelastic and platelet function tests are particularly useful to assist clinicians to rationalize FFP and platelet transfusions, when imminent death from exsanguination is not anticipated. Because the risks and benefits of blood product transfusion are heavily context-dependent, a thorough consideration of the characteristics and clinical status of the patients, in conjunction with viscoelastic and platelet function tests, is needed to rationalize the decision to transfuse (or withhold) blood products -very much in line with the move toward the practice of individualized or personalized medicine.

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Section: Evidence From Observational and Experimental Studiesmentioning

confidence: 99%

Context-dependent risks and benefits of transfusion in the critically ill

Harahsheh¹,

Ho²

2017

IJCTM

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“…platelet displacement from the core by erythrocytes and the Segré-Silberberg effect. The Level set method also appeared quite applicable to the description of erythrocyte migration towards the periaxial region with platelet displacement towards the wall [84].…”

Section: Plateletsmentioning

confidence: 99%

Segregation of Flowing Blood: Mathematical Description

Tokarev

Panasenko

Ataullakhanov

2011

Math. Model. Nat. Phenom.

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Abstract. Blood rheology is completely determined by its major corpuscles which are erythrocytes, or red blood cells (RBCs). That is why understanding and correct mathematical description of RBCs behavior in blood is a critical step in modelling the blood dynamics. Various phenomena provided by RBCs such as aggregation, deformation, shear-induced diffusion and non-uniform radial distribution affect the passage of blood through the vessels. Hence, they have to be taken into account while modelling the blood dynamics. Other important blood corpuscles are platelets, which are crucial for blood clotting. RBCs strongly affect the platelet transport in blood expelling them to the vessel walls and increasing their dispersion, which has to be considered in models of clotting. In this article we give a brief review of basic modern approaches in mathematical description of these phenomena, discuss their applicability to real flow conditions and propose further pathways for developing the theory of blood flow.

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“…Usually, the diffusivity of a species transported in the flow can be modeled using a Brownian diffusion approach. However, due to the presentence of the RBCs, the platelets tend to move to the walls of the vessel and the concentration of the platelets near the walls can be several times higher than the concentration near the vessel centerline [14,19,35]. In order to model the RBCs-induced platelets transport, based on the ideas proposed by Phillips et al [36], Wooton et al [37] and Hund & Antaki [27], we assume that the platelets diffusion flux, Q, can be given by, .…”

Section: The Diffusive Flux Of the Plateletsmentioning

confidence: 99%

“…Recently, based on mesoscale simulations which model both the fluid flow and the dynamics of each individual blood cell, such a non-uniform platelets distribution has been predicted successfully in several geometries [14,19,20]. Although these mesoscale simulations successfully replicated the non-uniform platelets distribution, due to their prohibitive computational cost for most engineering-scale problems, a continuum model is necessary.…”

Section: Introductionmentioning

confidence: 99%

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Numerical Simulation of Red Blood Cell-Induced Platelet Transport in Saccular Aneurysms

Aubry

et al. 2017

Applied Sciences

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Abstract:We present a numerical simulation of blood flow in two aneurysmal vessels. Using a multicomponent continuum approach, called mixture theory, the velocity fields and spatial distribution of the red blood cells (RBCs) and the plasma are predicted. Platelet migration is described by a convection-diffusion equation, coupled to the RBC concentration field. The model is applied to study a two-dimensional straight vessel and multiple two-dimensional aneurysm vessels with different neck sizes. The model accurately predicts the enrichment of the platelets near the wall in the straight vessel, agreeing with the experimental measurement quantitatively. The numerical results also show that the near-wall enrichment of the platelets in the parent vessel highly influences the platelet concentration within the aneurysm. The results also indicate that the platelet concentration within the aneurysm increases with Reynolds number and decreases with a smaller neck size. This might have significance on the formation of thrombus (blood clot) within the aneurysm, which in turn may have a protective effect on preventing ruptures. Based on the success with the problems studied, we believe the current model can be a useful tool for analyzing the blood flow and platelets transport within patient specific aneurysms in the future.

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Micro-scale Dynamic Simulation of Erythrocyte–Platelet Interaction in Blood Flow

Cited by 92 publications

References 44 publications

Context-dependent risks and benefits of transfusion in the critically ill

Context-dependent risks and benefits of transfusion in the critically ill

Segregation of Flowing Blood: Mathematical Description

Numerical Simulation of Red Blood Cell-Induced Platelet Transport in Saccular Aneurysms

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