Micro swimming mechanisms propelled by external magnetic fields

Honda, Toshio; Arai, Ken Ichi; Ishiyama, K.

doi:10.1109/20.539498

Cited by 223 publications

(130 citation statements)

References 3 publications

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“…http://dx.doi.org/10.1101/379024 doi: bioRxiv preprint first posted online Jul. 28, 2018; rotation of bacterial flagella, and the beating of paramecium cilia, which have so far inspired many synthetic swimmer designs (26)(27)(28)(29)(30)(31). Inspired by a similar mechanism, the design of our microrobotic swimmer is illustrated in Fig.…”

Section: Design Fabrication and Mobility Of Microswimmersmentioning

confidence: 99%

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Ceylan

Yasa

Yaşa

et al. 2018

Preprint

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Miniaturization of interventional medical devices can leverage minimally invasive technologiesby enabling operational resolution at cellular length scales with high precision and repeatability.Untethered micron-scale mobile robots can realize this by navigating and performing in hard-toreach, confined and delicate inner body sites. However, such a complex task requires an integrated design and engineering strategy, where powering, control, environmental sensing, medical functionality and biodegradability need to be considered altogether. The present study reports a hydrogel-based, biodegradable microrobotic swimmer, which is responsive to the changes in its microenvironment for theranostic cargo delivery and release tasks. We design a double-helical magnetic microswimmer of 20 µm length, which is 3D-printed with complex geometrical and compositional features. At normal physiological concentrations, matrix metalloproteinase-2 (MMP-2) enzyme can entirely degrade the microswimmer body in 118 h to solubilized non-toxic products. The microswimmer can respond to the pathological concentrations of MMP-2 by swelling and thereby accelerating the release kinetics of the drug payload. Anti-ErbB 2 antibodytagged magnetic nanoparticles released from the degraded microswimmers serve for targeted labeling of SKBR3 breast cancer cells to realize the potential of medical imaging of local tissue sites following the therapeutic intervention. These results represent a leap forward toward clinical medical microrobots that are capable of sensing, responding to the local pathological information, and performing specific therapeutic and diagnostic tasks as orderly executed operations using their smart composite material architectures.

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Section: Design Fabrication and Mobility Of Microswimmersmentioning

confidence: 99%

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Ceylan

Yasa

Yaşa

et al. 2018

Preprint

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“…136 An untethered robot, inspired by the bacterial flagellum, consisting of a permanent magnet (1 9 1 9 1 mm 3 ) attached to a rigid spiral wire (five turns of copper wire of diameter d=150 lm, and helix pitch of 3 mm), is described [ Fig. 6(a)].…”

Section: B3 Spiral-type Magnetic Capsulesmentioning

confidence: 99%

Magnetically guided capsule endoscopy

et al. 2017

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Wireless capsule endoscopy (WCE) is a powerful tool for medical screening and diagnosis, where a small capsule is swallowed and moved by means of natural peristalsis and gravity through the human gastrointestinal (GI) tract. The camera-integrated capsule allows for visualization of the small intestine, a region which was previously inaccessible to classical flexible endoscopy. As a diagnostic tool, it allows to localize the sources of bleedings in the middle part of the gastrointestinal tract and to identify diseases, such as inflammatory bowel disease (Crohn's disease), polyposis syndrome, and tumors. The screening and diagnostic efficacy of the WCE, especially in the stomach region, is hampered by a variety of technical challenges like the lack of active capsular position and orientation control. Therapeutic functionality is absent in most commercial capsules, due to constraints in capsular volume and energy storage. The possibility of using body-exogenous magnetic fields to guide, orient, power, and operate the capsule and its mechanisms has led to increasing research in Magnetically Guided Capsule Endoscopy (MGCE). This work shortly reviews the history and state-of-art in WCE technology. It highlights the magnetic technologies for advancing diagnostic and therapeutic functionalities of WCE. Not restricting itself to the GI tract, the review further investigates the technological developments in magnetically guided microrobots that can navigate through the various air-and fluid-filled lumina and cavities in the body for minimally invasive medicine.

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“…Helical propeller inspired by nature's bacterial swimming behaviors is promising for medical microrobots, because helical propulsion is suited to a low Reynolds number regime [2], [3]. In Japan, researchers proposed the first spiral type swimming mechanism with a cubic magnetic head driven by a rotating magnetic field [4]. This micro swimming mechanism was as large as a few millimetres.…”

Section: Introductionmentioning

confidence: 99%

Scaled-up helical nanobelt modeling and simulation at low reynolds numbers

Hwang²,

Andreff

et al. 2012

2012 IEEE International Conference on Robotics and Automation

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Abstract-Micro and nanorobots can change many aspects of medicine by enabling targeted diagnosis and therapy, and minimal invasive surgery. A helical nanobelt with a magnetic head was proposed as a microrobot driven by rotating magnetic field in prior works. Magnetically coated tails were already shown in some works. However the control of such surface magnetic tails is not clearly realized yet. This paper aims to obtain control parameters for the modeling and simulation of the influence of surface magnets onto the swimming performances. For this, we created scaled-up helical nanobelts and the experimental testbed to get the control parameters and to prepare future closed-loop control.

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Micro swimming mechanisms propelled by external magnetic fields

Cited by 223 publications

References 3 publications

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Magnetically guided capsule endoscopy

Scaled-up helical nanobelt modeling and simulation at low reynolds numbers

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