Micro-ultrasound for preclinical imaging

Foster, F. Stuart; Hossack, John A.; Adamson, S. Lee

doi:10.1098/rsfs.2011.0037

Cited by 102 publications

(85 citation statements)

References 143 publications

(218 reference statements)

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“…Conventional non-linear imaging techniques, at lower frequencies (515 MHz), focus mainly on detection of higher harmonics [101][102][103][104][105]. The need for high resolution UMI in small animal applications has pushed the frequencies used in preclinical imaging to above 15 MHz [106]. At these frequencies similar non-linear techniques have been implemented [107][108][109][110][111].…”

Section: Contrast-specific Imaging Techniquesmentioning

confidence: 99%

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Rooij

Daeichin

Skachkov

et al. 2015

International Journal of Hyperthermia

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Ultrasound contrast agents (UCAs) are used routinely in the clinic to enhance contrast in ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to their surface to target specific biomarkers of a disease or a disease process. These targeted UCAs (tUCAs) are used for a wide range of pre-clinical applications including diagnosis, monitoring of drug treatment, and therapy. In this review, recent achievements with tUCAs in the field of molecular imaging, evaluation of therapy, drug delivery, and therapeutic applications are discussed. We present the different coating materials and aspects that have to be considered when manufacturing tUCAs. Next to tUCA design and the choice of ligands for specific biomarkers, additional techniques are discussed that are applied to improve binding of the tUCAs to their target and to quantify the strength of this bond. As imaging techniques rely on the specific behaviour of tUCAs in an ultrasound field, it is crucial to understand the characteristics of both free and adhered tUCAs. To image and quantify the adhered tUCAs, the state-of-the-art techniques used for ultrasound molecular imaging and quantification are presented. This review concludes with the potential of tUCAs for drug delivery and therapeutic applications.

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Section: Contrast-specific Imaging Techniquesmentioning

confidence: 99%

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Rooij

Daeichin

Skachkov

et al. 2015

International Journal of Hyperthermia

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“…Ultrasound imaging was performed at E.12.5, E.15.5, and E.17.5 in each mouse to determine embryo/fetus vitality and in utero ICH, as previously described (31,67). Pregnant mice were anesthetized with 2% isoflurane (inhaled) and maintained on 1% during imaging.…”

Section: Detection Of Anti-β3 or Anti-gpibα Antibodies Via Flow Cytommentioning

confidence: 99%

Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage

Yougbaré¹,

Lang²,

Hong³

et al. 2015

J. Clin. Invest.

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“…The second category consists of papers on technologies that are just now beginning to impact upon clinical practice: real-time quasi-static ultrasound elastography [12], acoustic radiation force-based elasticity imaging [13] and ultrasonic image analysis and image-guided interventions [14]. The third category consists of papers that discuss contemporary research, which is either not directly concerned with clinical studies (micro-ultrasound for preclinical imaging [15]), or which, although promising, is still seen as being some time away from having an impact: biomedical photoacoustic imaging [16], ultrasound-mediated optical tomography [17], continuous wave ultrasonic Doppler tomography [18] and thermal strain imaging [19]. Since the perceived safety of ultrasonic imaging is often cited as being one of its advantages over most other modalities, there is a paper in the final category that puts this into perspective: ultrasonic imaging: safety considerations [20].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in biomedical ultrasonic imaging techniques

2011

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Nowadays in the UK, more than one quarter of all clinical imaging procedures use ultrasound and the number of ultrasonic scans that are performed each year exceeds all of those done by X-ray computed tomography, magnetic resonance imaging and radionuclide scanning combined [1]. Doubtless, the situation is similar in the rest of the world, but with ultrasound being even more used in lessdeveloped countries, because of its relatively low cost. Diagnostic ultrasound has come into its ascendency over the last 60 years, mutating from a laboratory curiosity being developed and promoted by very few innovative engineers and visionary clinicians (for instance, in the USA [2], in Japan (see [3]), in Sweden [4] and in the UK [5]) into an indispensible tool in modern routine clinical practice.Each of the wide range of different imaging modalities has its own individual characteristics. Usually in practice, the choice of the optimal modality is fairly obvious, because it depends on the clinical problem being investigated. Thus, for example, an X-ray is appropriate if a fracture is suspected, because X-rays are good at imaging bones. Likewise, for the management of cancer, positron emission tomography-a type of radionuclide scanning-can be invaluable because of its ability to visualize malignant tissue. The relative advantage of any particular modality lies essentially in the mechanism of the contrast in the images which it produces. In this respect, ultrasonic imaging is rather versatile. Primarily, the image contrast depends on differences in densities and speeds of sound, because these properties determine the scattering and reflectivity of tissue. In addition, flow, motion, strain and elasticity can be estimated ultrasonically and used to produce parametric images, for example, by colour maps superimposed on images of scattering and reflectivity. Moreover, ultrasonic imaging is fast and apparently safe, as well as being well liked by patients. Thus, the technology is particularly valuable in clinical practice in obstetrics and gynaecology, internal medicine, genitourinary studies, cardiology, vascular studies, dermatology and breast disease, but it is not of much use in the investigation of gas-containing or bony structures.Ultrasonic imaging is a mature medical technology, the evolution of which has been the result of many years of biomedical engineering and clinical research. Moreover, the level of contemporary research activity is great and it covers a vast range of emerging opportunities. Very many ultrasound papers appear in medical journals devoted to the various clinical specialties and these generally report on the expansion of the diagnostic horizons, which results from novel applications and observations with existingalbeit often new-technologies. In organizing this Theme Issue of Interface Focus, however, we sought to compile papers that would be representative of advances in the technologies themselves, sometimes even before their clinical potentials have been explored. Of course, our intention certainly was ...

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Micro-ultrasound for preclinical imaging

Cited by 102 publications

References 143 publications

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage

Recent advances in biomedical ultrasonic imaging techniques

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