Micro‐ultrasound may significantly reduce the proportion of unnecessary prostate biopsies in patients with PI‐RADS 3 lesions

Avolio, Pier Paolo; Lazzeri, Massimo; Buffi, Nicolò Maria; Lughezzani, Giovanni

doi:10.1002/cncr.34549

Cited by 1 publication

(1 citation statement)

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“…In parallel, mUS enhances the diagnostic evaluation for patients with prior negative biopsies, a group often facing continuing uncertainty of prostate cancer risk. Notably, mUS has proven effective in discerning cases within the ambiguous realm of PI-RADS 3 lesions on mpMRI, adeptly minimizing the identification of ciPCa while reliably detecting csPCa [ 44 ]. Similarly, mUS has been proven to be as effective in the management of patients under active surveillance as event-triggered confirmatory biopsy [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies

Beatrici,

Frego,

Chiarelli

et al. 2024

Diagnostics

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Background: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases. Methods: A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa). Results: In our cohort of 1397 men, 304 had a history of negative biopsies. mUS was more sensitive than mpMRI, with better predictive value for negative results. Importantly, mUS was significantly associated with csPCa detection (adjusted odds ratio [aOR]: 6.58; 95% confidence interval [CI]: 1.15–37.8; p = 0.035). Conclusions: mUS may be preferable for diagnosing prostate cancer in previously biopsy-negative patients. However, the retrospective design of this study at a single institution suggests that further research across multiple centers is warranted.

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Section: Discussionmentioning

confidence: 99%