Microactuators are essential elements of MEMS and are widely used in these devices. Microgrippers, micropositioners, microfixtures, micropumps and microvalves are well-known applications of microstructures. In this paper, the design optimization of shape memory alloy microactuators is discussed. Four different configurations of microactuator with variable geometrical parameters, generating different levels of displacement and force, are designed and analysed. In order to determine the optimum values of parameters for each microactuator, statistical design of experiments (DOE) is used. For this purpose, the Souza et al constitutive model (1988 Eur. J. Mech. A 17 789-806) is adapted for use in finite element analysis software. Mechanical properties of the SMA are identified by performing experimental tests on Ti-49.8%Ni. Finally, the specific energy of each microactuator is determined using the calibrated model and regression analysis. Moreover, the characteristic curve of each microactuator is obtained and with this virtual tool one can choose a microactuator with the desired force and displacement. The methodology discussed in this paper can be used as a reference to design appropriate microactuators for different MEMS applications producing various ranges of displacement and force.