Microalbuminuria and Cardiovascular Disease in Hypertensive Patients Included in the Iberican Study

Díaz, M.A. Prieto; Sanjurjo, Sergio Cinza; Caro, Jorge; Carratalá, Vicente; García, J. Polo; Vargas, Manuel Frías; Pais, Prem; Freire, Santiago Jesús Camacho; Secin, A.A. Romero; Escribano, Francisca Molina; Jimenez, S.; Roca, G.C. Rodríguez; Alles, Gordon A.; Escobar, Fabrícia Teixeira; Carrasco, Eduardo; Iturralde-Iriso, Jesús; Mendoza, Leonor; Baz, Patricia; Criado, E.

doi:10.1097/01.hjh.0000539505.95319.15

Cited by 1 publication

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“…Chronic kidney disease and renal failure are associated with an increased CVR due to the excess release of renin [50] Microalbuminuria (MA) A constant elevation of albumin in urine. It signifies endothelial dysfunction and is therefore associated with CVR [51] Cystatin-C A low molecular-weight protein who's increased circulating concentrations appear to have an increased CVR [52] Necrosis Troponin 1 A protein found in skeletal and heart (cardiac) muscle fibres that regulate muscular contraction. Increased levels Troponin 1 are strongly associated with the incidence of CVD [53] Creatine kinase-MB (CK-MB)…”

Section: Creatininementioning

confidence: 99%

Genetic Polymorphisms and Their Interactions with the Risk Factors of Cardiovascular Diseases: Review Chapter

Chalwe¹,

Grobler²,

Oldewage‐Theron³

2022

Risk Factors for Cardiovascular Disease

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Cardiovascular diseases (CVDs) have been reported to have a complex pathogenesis by a number of studies. Atherosclerosis and inflammation have been established as the main contributors to CVDs. Furthermore, genetic polymorphisms have been identified and found to have a correlation with an individual’s susceptibility to developing CVD. Some of these polymorphisms and corresponding cardiovascular risk (CVR) factors include: C174G (Interleukin (IL)-6 association), methylenetetrahydrofolate reductase (MTHFR) C667T/A1298C (hyperhomocysteinaemia), VII R353Q (coagulation factor VII association) and rs247616/rs1968905/rs1270922 (cholesteryl ester transfer protein (CEPT) - cholesterol metabolism) amongst others. At a time when disease prediction, diagnosis and prognosis are still being investigated, these polymorphisms have the potential for use in these areas as well as opening more opportunities in the understanding of CVD. The objective of this chapter was to review the current knowledge about the relationship between genetic polymorphisms and cardiovascular disease.

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