Microalbuminuria and glycated hemoglobin in children with type 1 diabetes mellitus

Omar, Magdy; Rezk, Moustafa M.; El-Kafoury, Ahmed A.; Kandil, Marwa S.

doi:10.1016/j.ajme.2014.04.005

Cited by 10 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be due to the interaction of genetic and environmental factors. 59 Moreover, a study on Egyptian subjects with T1D demonstrated that 77.5% of the studied children with diabetes developed early nephropathy, 53 which is considered significantly higher than what was previously reported by the American Diabetes Association (20-40%). 60 The prevalence of T1D and its complications is steadily increasing in the Arab world.…”

Section: Figurementioning

confidence: 75%

“…After removal of duplicates, 372 articles were identified, of which, 321 irrelevant articles were excluded (Figure ). The remaining 41 articles were eligible for systemic review, whereas a full text review of these 41 articles revealed that only 15 studies were eligible for meta‐analysis (Figure ). Due to the few reports about DN among Arab patients with T1D, we included all captured articles regardless of age; therefore, the captured subjects in this study represent heterogeneous populations of both children and adults of all ages ranging from 5 to 70 years of age.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta‐analysis

Abdel-Motal

Akila

Abdelalim

et al. 2018

Diabetes Metabolism Res

View full text Add to dashboard Cite

The aim of this study was to conduct a systematic review and meta-analysis and determine the prevalence of diabetic nephropathy (DN) among Arab patients with T1D. A systematic literature search was conducted using 4 different literature databases (PubMed, ScienceDirect, Web of Science, and Embase) to capture all relevant data about Arab patients with T1D that had DN. Meta-analysis and systematic review were performed using the random effect model, and the heterogeneity of the studies was assessed using the Q-test, I2, and Tau-squared statistics. Publication bias was assessed using the funnel-plot test. Our search strategy captured 372 studies in only 10 out of the 22 Arab countries in a period of 48 years (1969-2017); of which, 41 met our inclusion criteria for full article analysis, of those, 15 were eligible for meta-analysis. We estimated the prevalence of DN among Arab people with T1D to be 18.2% (95% confidence interval 13.1%-24.8%). In conclusion, DN prevalence is underexplored among Arab patients with T1D and represents a significant risk for the well-being of Arab patients with T1D. Therefore, there is an urgent need for comprehensive epidemiological studies for DN among Arab patients with T1D.

show abstract

Section: Figurementioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta‐analysis

Abdel-Motal

Akila

Abdelalim

et al. 2018

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

“…The present review also attempted to conduct a subgroup analysis based on sub-region, gender, publication year, and diabetes type. MAU had the highest pooled prevalence of 46.50% (95% CI: 32.29–60.71) in studies conducted in Northern Africa, 48 , 58 , 61 , 65 followed by 40.81 (95 CI: 30.85–50.76) in studies conducted in Western Africa. 42–45 , 59 , 62 , 66 , 67 This disparity could be attributed to differences in study subjects, urine collection methods, the presence of comorbidity, and assay methods used in those African countries.…”

Section: Discussionmentioning

confidence: 97%

Prevalence of Microalbuminuria Among Diabetes Patients in Africa: A Systematic Review and Meta-Analysis

Mohammed¹,

Alemayehu²,

Bisetegn³

et al. 2023

DMSO

View full text Add to dashboard Cite

Background Microalbuminuria (MAU) is considered the earliest sign of diabetic nephropathy among diabetes patients. In order to effectively manage diabetic nephropathy and its consequences early, detection of microalbuminuria as soon as possible, especially for diabetes patients, is critical. Therefore, the present study aimed to determine the pooled prevalence of microalbuminuria among diabetes patients in Africa. Methods Electronic databases such as Google Scholar, PubMed, African Journals Online, Web of Science, Cochrane Library, EMBASE, and ResearchGate were searched for articles and grey literature. The STATA version 14 software was used to conduct the meta-analysis. I 2 and Cochran’s Q test were employed to assess the presence of heterogeneity between studies. Due to the presence of heterogeneity, a random effect model was used. The publication bias was assessed using the symmetry of the funnel plot and Egger’s test statistics. Moreover, subgroup analysis, trim and fill analysis, and sensitivity analysis were also done. Results The overall pooled prevalence of microalbuminuria among diabetes patients in Africa was 37.11% (95% CI 31.27–42.95). Substantial heterogeneity was observed between studies, with I 2 values of 94.7%. Moreover, this meta-analysis showed that the pooled estimate of microalbuminuria among type 1 and type 2 diabetes patients was 35.34% (95% CI: 23.89–46.80, I 2 =94.2), and 40.24% (95% CI: 32.0–48.47, I 2 =94.9) respectively. MAU, on the other hand, was more common in people with diabetes for more than 5 years 38.73% (95% CI: 29.34–48.13) than in people with diabetes for less than 5 years 31.48% (95% CI: 18.73–44.23). Conclusion This systematic review and meta-analysis found a high prevalence of microalbuminuria among diabetes patients. As a result, early detection of microalbuminuria is critical for preventing and treating microvascular complications such as diabetic nephropathy and the onset of end-stage renal disease.

show abstract

“…[ 11 ] in Sweden, though both studies had a higher cohort and their population was followed for more than 15 years unlike our cohort that is less than 10 years, where the possibility of status change can influence the glycaemic controls. Three studies in Africa reported high UAC ratios in children and all attributed these to poor glycaemic controls of the population though one was a systemic review [ 4 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Microalbuminuria in type 1 diabetes mellitus children in University of Port Harcourt Teaching Hospital, Nigeria

2020

View full text Add to dashboard Cite

Introduction glycaemic control is usually best achieved using the basal bolus regimen, however, this is not always available in resource-limited settings. Long-term complications like renal parenchymal disease are consequences of poor glycaemic control. Screening type 1 diabetes patients irrespective of their disease duration was used to buttress the need for ethical principles of justice to be incorporated in the care of type 1 diabetes children. Methods urine albumin creatinine ratio (UAC) was calculated for 20 type 1 diabetes mellitus children in the endocrinology clinic after submitting early morning urine over a 4-month period. The calculated ratio was compared between duration of disease (< 5 years and > 5 years) and between insulin regimen types (mixtard and basal bolus). Repeat tests were done for children who had elevated UAC ratio levels after 2 months. Results there were 5 males and 15 females and the mean UAC ratio of the cohort was 123mg/g with a range of 5.30 − 906 mg/g. Twelve children (8 diagnosed less than 5 years) had UAC ratio ≥ 30mg/g with a mean of 193.15. The repeat mean UAC ratio for these was 144.35 mg/g. Children who had diabetes for more than 5 years and were on mixtard had higher UAC ratio than those with diabetes < 5 years and on basal bolus. Conclusion the prevalence of microalbuminuria is high in our cohort of type 1 diabetes children and these were children on mixtard and had diabetes greater than 5 years.

show abstract

Microalbuminuria and glycated hemoglobin in children with type 1 diabetes mellitus

Cited by 10 publications

References 23 publications

Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta‐analysis

Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta‐analysis

Prevalence of Microalbuminuria Among Diabetes Patients in Africa: A Systematic Review and Meta-Analysis

Microalbuminuria in type 1 diabetes mellitus children in University of Port Harcourt Teaching Hospital, Nigeria

Contact Info

Product

Resources

About