Microalbuminuria in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Patients on Antiretroviral Therapy in Zaria, Nigeria

Yusuf, Rasheed; Aliyu, Ibrahim; Muktar, Haruna M; Hassan, Abdulaziz

doi:10.4103/2384-5147.136818

Cited by 6 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24 However, the present result is in contrast with the results of some other similar studies documenting significantly elevated creatinine levels in HIV participants and HIV participants on ART compared to control group. 11,[13][14][15][16][17][18][19][20][21][22][23][24][25] Creatinine is a non-protein nitrogenous compound that is produced by the breakdown of creatine in muscle. Creatinine is found in serum, plasma, and urine and is excreted glomerular filtration at a constant rate and in the same concentration as in plasma.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated levels of microalbumin have been reported in HIV positive patients in previous times which are in contrast with the present finding. 11,[13][14][15]22 Expectedly, Cystatin C level was found to be significantly higher in HIV participants than in control. This implies that the HIV population may be at a higher risk of renal disease in the near future compared with HIV negative individuals.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10] It follows therefore that long-term use of ART may cause kidney derangements that may become lifethreatening. 11 Previously, 12 some authors have investigated several other biochemical parameters among HIV positive individuals 13,14 , but in this study, the key interested shall be focused on evaluating microalbumin, cystatin C, creatinine and uric acid levels as renal diagnostic biomarkers of emerging relevance. The term microalbuminuria (MA) is used to describe albumin concentrations in the urine that are greater than normal, but not detectable with conventional urine dipstick analysis and it is useful as an early biomarker in the detection of kidney disease.…”

Section: Introductionmentioning

confidence: 99%

“…11 Elevated levels of microalbumin have been reported in HIV positive patients. 11,[13][14][15][16] Cystatin C is a plasma protein (13 kDa) that is produced by all nucleated cells in the human body and functions as the cysteine protease inhibitor. 17 Some studies indicate that the changes in cystatin C levels may contribute in the detection of renal failure 18,19 andseveral studies have shown elevated levels of cystatin C in HIV positive patients in recent times.…”

Section: Introductionmentioning

confidence: 99%

“…17 Some studies indicate that the changes in cystatin C levels may contribute in the detection of renal failure 18,19 andseveral studies have shown elevated levels of cystatin C in HIV positive patients in recent times. 20,21 Creatinine is freely excreted through kidneys which makes it useful to interpret kidney function and elevated levels of creatinine have been seen in HIV positive persons 11,[13][14][15][16][17][18][19][20][21][22][23] although some others recorded no significant alterations. 24,25 Elevated serum uric acid levels are associated with endothelial dysfunction in HIV patients.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of microalbumin, cystatin c, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi

Priscilla¹,

Clement²,

Chukwuemeka³

et al. 2021

JCHM

View full text Add to dashboard Cite

This study evaluated the microalbumin, cystatin C, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi (NAUTH). A total of one hundred (100) male and female HIV positive and control participants who were aged between 18 and 60 years attending the voluntary counseling and testing unit (VCT) and antiretroviral therapy unit (ART) of NAUTH were randomly recruited for the study and grouped thus: Group A (HIV positive symptomatic participants on long term ART (HPSPLTART) (n= 25); Group B (HIV positive symptomatic participants on short term ART (HPSPSTART) (n= 25); Group C: Asymptomatic HIV positive participants NOT on ART (AHPPNART) (n=25) and Group D: control (n=25).6mls of blood sample and 10mls of freshly voided urine samples were collected from each of the participants for the evaluation of biochemical parameters using standard laboratory methods. Results showed significantly higher BMI and SBP in HPSPSTART than in control (p=0.04; 0.02). SBP was significantly higher in HPSPLTART than in AHPPNART and Control (p=0.00). DBP was significantly higher in HPSPLTART than in HPSPSTART and control respectively (p=0.00). There were significantly higher plasma creatinine and Cys-C levels in both male HIV positives and male HIV positive participants on ART than in both females respectively (p0.00; 0.02). Also, BMI, creatinine, uric acid and Cystatin C levels were significantly higher in male HIV negative participants than in female HIV negative participants (p=0.00; 0.04; 0.02; 0.01). This study has revealed greater risk for renal disease among the HIV participants studied.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of microalbumin, cystatin c, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi

Priscilla¹,

Clement²,

Chukwuemeka³

et al. 2021

JCHM

View full text Add to dashboard Cite

show abstract

Apolipoprotein-1 risk variants and associated kidney phenotypes in an adult HIV cohort in Nigeria

Wudil

Aliyu

Prigmore

et al. 2021

Kidney International

View full text Add to dashboard Cite

Duration of Tenofovir Use and Diabetes Mellitus Predict Microalbuminuria among Well-controlled Human Immunodeficiency Virus-infected Patients Attending a Tertiary Clinic in Gaborone, Botswana

Akerele,

Rivera,

Rwegerera

2022

Saudi Journal of Kidney Diseases and Transplantation

View full text Add to dashboard Cite

The study aimed to determine the prevalence and associated factors of microalbuminuria among patients infected with human immunodeficiency virus (HIV). A cross-sectional study was conducted at the Infectious Disease Control Center of Princess Marina Hospital, a Tertiary Clinic in Gaborone, Botswana. The risk factors of microalbuminuria were determined by comparing the sociodemographic and clinical characteristics of patients with the presence of microalbuminuria or normoalbuminuria. In total, 297 randomly selected HIV-infected patients were included in the analysis. The mean age of the study participants was 48.6 years, with the majority of patients (60.9%) being females. The study participants were largely well-controlled both immunologically and virologically, with 283/297 (95.3%) and 280/297 (94.3%), having CD4 counts of more than 200 cells/mm3 and undetected viral load (<400 copies/mL), respectively. The prevalence of microalbuminuria was found to be 46.5%. Microalbuminuria was associated with the duration of exposure to a regimen containing tenofovir [P <0.001, odds ratio = 1.137, 95% confidence interval (CI) = 1.073–1.205] and a history of diabetes mellitus (P = 0.044, odds ratio = 9.260, 95% CI = 1.058–81.06). Sociodemographic characteristics and other clinical factors were not associated with microalbuminuria. There is a need to carry out prospective studies among HIV- infected patients with microalbuminuria to determine the short- and long-term cardiovascular morbidity and mortality outcomes.

show abstract

Microalbuminuria in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Patients on Antiretroviral Therapy in Zaria, Nigeria

Cited by 6 publications

References 1 publication

Evaluation of microalbumin, cystatin c, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi

Evaluation of microalbumin, cystatin c, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi

Apolipoprotein-1 risk variants and associated kidney phenotypes in an adult HIV cohort in Nigeria

Duration of Tenofovir Use and Diabetes Mellitus Predict Microalbuminuria among Well-controlled Human Immunodeficiency Virus-infected Patients Attending a Tertiary Clinic in Gaborone, Botswana

Contact Info

Product

Resources

About