Microalbuminuria in inflammatory bowel disease.

Mahmud, Nasir; Stinson, J.; O’Connell, Maria A.; Mantle, Timothy J.; Keeling, P. W. N.; Feely, J.; Weir, D. G.; Kelleher, Dermot

doi:10.1136/gut.35.11.1599

Cited by 59 publications

(72 citation statements)

References 37 publications

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“…Th ere is no clear relationship between dose and the risk of nephrotoxicity, raising the possibility that this reaction might be idiosyncratic ( 100 ). In addition, patients with active IBD may develop an increase in microalbuminuria in the presence of active disease ( 101 ). Furthermore in an epidemiologic study of over 20,000 IBD patients from the UK, there was not an increased incidence of nephrotoxicity in IBD patients taking mesalamine compounds, compared with IBD patients without mesalamine use ( 102 ).…”

Section: Recommendations For Management Of Mild -Moderate Distal Colitismentioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

1,156

977

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Guidelines for clinical practice are aimed to indicate preferred approaches to medical problems as established by scientifi cally valid research. Double-blind placebo controlled studies are preferable, but compassionate-use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. When only data that will not withstand objective scrutiny are available, a recommendation is identifi ed as a consensus of experts. Guidelines are applicable to all physicians who address the subject regardless of specialty training or interests and are aimed to indicate the preferable but not necessarily the only acceptable approach to a specifi c problem. Guidelines are intended to be fl exible and must be distinguished from standards of care, which are infl exible and rarely violated. Given the wide range of specifi cs in any healthcare problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. Guidelines are developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee and approved by the board of trustees. Each has been intensely reviewed and revised by the Committee, other experts in the fi eld, physicians who will use them, and specialists in the science of decision analysis. The recommendations of each guideline are therefore considered valid at the time of composition based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at a time established and indicated at publication to assure continued validity. The recommendations made are based on the level of evidence found. Grade A recommendations imply that there is consistent level 1 evidence (randomized controlled trials), grade B indicates that the evidence would be level 2 or 3, which are cohort studies or case -control studies. Grade C recommendations are based on level 4 studies, meaning case series or poor-quality cohort studies, and grade D recommendations are based on level 5 evidence, meaning expert opinion.

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Section: Recommendations For Management Of Mild -Moderate Distal Colitismentioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

1,156

977

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“…It is therefore not surprising that several studies have shown microalbumin excretion to be positively correlated with blood pressure, especially at pressures Ͼ150/90 mm Hg. 2,9 Thus microalbumin excretion reflects minute by minute changes in vascular endothelial permeability and has been found to be associated with many inflammatory processes such as bacterial meningitis, 10 rheumatoid arthritis, 11 inflammatory bowel disease, 12 acute pancreatitis, 13 trauma 14 and surgery. 15 In each condition microalbumin excretion is proportional to the severity of the condition, and since it occurs within minutes of acute insults, is of value in predicting later complications associated with interstitial oedema, such as acute respiratory distress syndrome.…”

Section: In This Issue Drs Reid Et Almentioning

confidence: 99%

Microalbuminuria and cardiovascular risk: a word of caution

Gosling

1998

J Hum Hypertens

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“…If MAL represented vascular numbers of enrolled patients have further addressed damage and had prognostic implications, hypertenthe controversy on the role of MAL as a cardiovascusive target organ damage may thus be more common lar risk factor in hypertension. 20 24 suggesting increased microvascular permeability probably secondary to group was 31%, 24%, 6% and 7% which was significantly higher compared to corresponding values inflammatory mediators such as the cytokines. 24 However, MAL may also be considered to reflect in the normoalbuminuric group (22%, 14%, 4% and 5%, respectively; P Ͻ 0.0001).…”

mentioning

confidence: 81%

“…20 24 suggesting increased microvascular permeability probably secondary to group was 31%, 24%, 6% and 7% which was significantly higher compared to corresponding values inflammatory mediators such as the cytokines. 24 However, MAL may also be considered to reflect in the normoalbuminuric group (22%, 14%, 4% and 5%, respectively; P Ͻ 0.0001). local renal dysfunction characterised by increased intraglomerular pressure and filtration fraction, In this issue of the Journal of Human Hypertension, we report a study by Jensen et al 21 of 1254 leading to increased transglomerular membrane albumin passage and subsequently nephrosclerosis.…”

mentioning

confidence: 81%