Microalbuminuria, Indicated by Total versus Immunoreactive Urinary Albumins, in Acute Ischemic Stroke Patients

Tóth, Péter; Koller, Ákos; Pusch, Gabriella; Bosnyák, Edit; Szekeres, L.; Komoly, Sámuel; Markó, Lajos; Nagy, Judit; Wittmann, István

doi:10.1016/j.jstrokecerebrovasdis.2010.03.002

Cited by 12 publications

(14 citation statements)

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“…1 Baseline characteristics and univariate analysis for presence of microalbuminuria (MA) of included patients divided into those with and without MA, and univariate analysis for modified Rankin score (mRS) upon discharge in the studied population for stroke severity. This study differs in some respects from our and most other published investigations: MA was assessed not with three independent measurements or with 24-h urine but by determination of the albumin/creatinine ratio in a single urine sample, and Toth et al [10] do not give information about the outcome of stroke patients.…”

Section: Discussioncontrasting

confidence: 58%

“…However, they reported no data on the association between MA and neurological severity or outcome in the acute phase. Toth et al [10] did not confirm that immunoreactive (immunologically intact) albumin, which is typically measured as a marker MA serves as an independent risk factor for stroke severity. In this study of 98 patients, only a subtype of albumin (non-immunoreactive albumin) was an independent risk factor Tab.…”

Section: Discussionmentioning

confidence: 97%

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Microalbuminuria

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 97%

Microalbuminuria

et al. 2012

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“…14 In another study we found that albuminuria (both total and non-immunoreactive) showed a good correlation with urinary o-Tyr/creatinine ratio in patients suffering from ischemic stroke. 15 Additionally, we detected higher levels of m-Tyr and o-Tyr in total homogenates of cataractous lenses. 16 Hypotheses of the study were as following: (i) The hydroxyl free radical-derived Tyr isoforms are elevated in the sera and urine of septic patients as compared to controls.…”

Section: Introductionmentioning

confidence: 65%

Time courses of changes ofpara-,meta-, andortho-tyrosine in septic patients: A pilot study

et al. 2016

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“…16 Formerly we had also observed that the total urinary albumin/creatinine ratio and urinary non-immunoreactive albumin/creatinine ratio show a significant correlation with the urinary ortho-tyrosine/creatinine ratio in patients with acute ischemic stroke. 17 Finally, administration of natural antioxidant resveratrol significantly decreased ortho-tyrosine excretion and improved insulin resistance in patients with type 2 diabetes mellitus. 18 Vivekanadan-Giri et al 19 found the ortho-tyrosine level to be elevated in the aortic proteins of diabetic monkeys.…”

Section: Introductionmentioning

confidence: 98%

Association of plasmaortho-tyrosine/para-tyrosine ratio with responsiveness of erythropoiesis-stimulating agent in dialyzed patients

et al. 2014

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Objectives Patients with end-stage renal failure (ESRF) treated with erythropoiesis-stimulating agents (ESAs) are often ESA-hyporesponsive associated with free radical production. Hydroxyl free radical converts phenylalanine into ortho-tyrosine, while physiological isomer para-tyrosine is formed enzymatically, mainly in the kidney. Production of 'para-tyrosine' is decreased in ESRF and it can be replaced by ortho-tyrosine in proteins. Our aim was to study the role of tyrosines in ESA-responsiveness. Methods Four groups of volunteers were involved in our cross-sectional study: healthy volunteers (CONTR; n = 16), patients on hemodialysis without ESA-treatment (non-ESA-HD; n = 8), hemodialyzed patients with ESA-treatment (ESA-HD; n = 40), and patients on continuous peritoneal dialysis (CAPD; n = 21). Plasma ortho-, para-tyrosine, and phenylalanine levels were detected using a high performance liquid chromatography (HPLC)-method. ESA-demand was expressed by ESA-dose, ESA-dose/body weight, and erythropoietin resistance index1 (ERI1, weekly ESA-dose/body weight/hemoglobin). Results We found significantly lower para-tyrosine levels in all groups of dialyzed patients when compared with control subjects, while in contrast ortho-tyrosine levels and ortho-tyrosine/para-tyrosine ratio were comparatively significantly higher in dialyzed patients. Among groups of dialyzed patients the ortho-tyrosine level and ortho-tyrosine/para-tyrosine ratio were significantly higher in ESA-HD than in the non-ESA-HD and CAPD groups. There was a correlation between weekly ESA-dose/body weight, ERI1, and ortho-tyrosine/para-tyrosine ratio (r = 0.441, P = 0.001; r = 0.434, P = 0.001, respectively). Our most important finding was that the ortho-tyrosine/para-tyrosine ratio proved to be an independent predictor of ERI1 (β = 0.330, P = 0.016). In these multivariate regression models most of the known predictors of ESA-hyporesponsiveness were included. Discussion Our findings may suggest that elevation of the ratio of ortho-tyrosine/para-tyrosine could be responsible for decreased ESA-responsiveness in dialyzed patients.

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Microalbuminuria, Indicated by Total versus Immunoreactive Urinary Albumins, in Acute Ischemic Stroke Patients

Cited by 12 publications

References 50 publications

Microalbuminuria

Microalbuminuria

Time courses of changes ofpara-,meta-, andortho-tyrosine in septic patients: A pilot study

Association of plasmaortho-tyrosine/para-tyrosine ratio with responsiveness of erythropoiesis-stimulating agent in dialyzed patients

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