Microalgal drugs: A promising therapeutic reserve for the future

Ahirwar, Ashok Kumar; Kesharwani, Khushboo; Deka, Rahul; Muthukumar, Shreya; Khan, Mohd Jahir; Rai, Anshuman; Vinayak, Vandana; Varjani, Sunita; Joshi, Khashti Ballabh; Morjaria, Shruti

doi:10.1016/j.jbiotec.2022.03.012

Cited by 31 publications

(12 citation statements)

References 188 publications

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“…In accordance, [ 22 ] found that the best antiviral effect against Mayaro Fever (due to the arbovirus MAYV) was obtained using extracts from A. platensis at the stationary phase. In those extracts, terpenoids, flavonoids, fatty acids and carotenoids were detected, essentially compounds with antiviral/antioxidant effects [ 19 , 22 , 44 ]. Similarly, [ 45 ] used extracts from several microalgae harvested at the stationary phase of growth for their experiments against hemorrhagic septicemia virus (VHSV) and African swine fever virus (ASFV).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Neochloris oleoabundans under Different Cultivation Modes and First Results on Bioactivity of Its Extracts against HCoV-229E Virus

Baldisserotto

Gentili

Rizzo

et al. 2022

Plants

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Microalgae are proposed in several biotechnological fields because of their ability to produce biomass enriched in high-value compounds according to cultivation conditions. Regarding the health sector, an emerging area focuses on natural products exploitable against viruses. This work deals with the characterization of the green microalga Neochloris oleoabundans cultivated under autotrophic and mixotrophic conditions as a source of whole aqueous extracts, tested as antivirals against HCoV-229E (Coronaviridae family). Glucose was employed for mixotrophic cultures. Growth and maximum quantum yield of photosystem II were monitored for both cultivations. Algae extracts for antiviral tests were prepared using cultures harvested at the early stationary phase of growth. Biochemical and morphological analyses of algae indicated a different content of the most important classes of bioactive compounds with antiviral properties (lipids, exo-polysaccharides, and total phenolics, proteins and pigments). To clarify which phase of HCoV-229E infection on MRC-5 fibroblast cells was affected by N. oleoabundans extracts, four conditions were tested. Extracts gave excellent results, mainly against the first steps of virus infection. Notwithstanding the biochemical profile of algae/extracts deserves further investigation, the antiviral effect may have been mainly promoted by the combination of proteins/pigments/phenolics for the extract derived from autotrophic cultures and of proteins/acidic exo-polysaccharides/lipids in the case of mixotrophic ones.

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Section: Discussionmentioning

confidence: 99%

Characterization of Neochloris oleoabundans under Different Cultivation Modes and First Results on Bioactivity of Its Extracts against HCoV-229E Virus

Baldisserotto

Gentili

Rizzo

et al. 2022

Plants

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Section: Introductionmentioning

confidence: 99%

“…Most algal extracts contain carbohydrates, proteins, minerals, oils, fats, and polyunsaturated fatty acids as well as bioactive compounds which possess antioxidant, antibacterial, antifungal, antiviral, antitumor, and anti-inflammatory properties. , The introduction of CNMs to the algal system establishes a sustainable alternate route for the extraction of various bioactive components advancing pivotal roles in prevention and treatment of human health diseases such as cardiovascular, cancer, inflammation, and numerous nervous system disorders . These bioactive compounds are essential nutrients that modulate several metabolic processes and promote human health. , In contrast to other synthetic drugs, algal drugs are naturally endowed with numerous promising attributes, such as being biocompatible, biodegradable, and nontoxic in nature, which establish algae as an exceptional source for extraction of bioactive compounds …”

Section: Introductionmentioning

confidence: 99%

“…12,13 In contrast to other synthetic drugs, algal drugs are naturally endowed with numerous promising attributes, such as being biocompatible, biodegradable, and nontoxic in nature, which establish algae as an exceptional source for extraction of bioactive compounds. 14 Recent attempts have used genetic engineering to enable the creation of recombinant proteins, as well as optogenetic control to induce gene expression. 15 Plants became a biotechnological focus in the late 1980s as an expression system for recombinant proteins, because they offer all of the benefits of higher eukaryotic expression systems but are powered by photosynthesis and thus do not require external carbon sources.…”

Section: ■ Introductionmentioning

confidence: 99%

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Exploring the Role of Carbon-Based Nanomaterials in Microalgae for the Sustainable Production of Bioactive Compounds and Beyond

et al. 2022

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An enchanting yet challenging task is the development of higher productivity in plants to meet the ample food demands for the growing global population while harmonizing the ecosystem using front-line technologies. This has kindled the practice of green microalgae cultivation as a driver of key biostimulant products, targeting agronomic needs. To this end, a prodigious and economical strategy for producing bioactive compounds (sources of secondary metabolites) from microalgae using carbon-based nanomaterials (CNMs) as a platform can circumvent these hurdles. Recently, the nanobionics approach of incorporating CNMs with living systems has emerged as a promising technique to develop organelles with new and augmented functions. Herein, we discuss the importance of 2D carbon nanosheets (CNS) as an alternative carbon source for the phototrophic cultivation of microalgae. CNS not only aids in cost reduction for algal cultivation but also confers combinatorial innate or exogenous functions that enhance its programmed biosynthetic metabolism, proliferation, or tolerance to stress. Moreover, the inherent ability of CNS to act as efficient biocatalysts can enhance the rate of photosynthesis. The primary focus of this mini-review is the development of an economic route for enhanced yield of bioactive compounds while simultaneously serving as a heterogeneous platform for enhancing the sustainable production of biostimulants including bioactive compounds from algal biomass for pharmaceutical and nutraceutical applications.

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“…Unfortunately, some of the products are molecules that cannot currently be reproduced by chemical synthesis [10]. MA and CB are currently attracting much attention of scientists due to the high biological activity of secondary metabolites of these aquatic organisms [11].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Effects and Mechanisms of Action of Water Extracts and Polysaccharides of Microalgae and Cyanobacteria

Беседнова

Andryukov

Кузнецова

et al. 2022

J. Pharm. Nutr. Sci.

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Microalgae (MA) and cyanobacteria (CB) are currently attracting much attention from scientists due to the high biological activity of many secondary metabolites of these aquatic organisms. This review presents up-to-date modern data on the prospects for using polysaccharides (PS) of these marine aquatic organisms as effective and practically safe antiviral agents. These natural biopolymers are polyvalent compounds, which allows them to bind to several complementary biological target receptors. Particular emphasis is placed on the exopolysaccharides (EPS) Spirulina sp. (Arthrospira sp.), Porphyridium sp., Chlorella sp., and Euglena sp., whose antiviral activity makes them promising for the creation of drugs, biologically active food supplements, and products for functional nutrition. The mechanisms of the biological action of PS and the targets of these compounds are presented with a brief description of PS's anti-inflammatory, immunomodulatory and antioxidant actions, which make the most significant contribution to the antiviral effects. The authors hope to draw the attention of researchers to the use of water extracts and polysaccharides of microalgae and cyanobacteria as potential broad-spectrum antiviral agents that can become the basis for new antivirus strategies.

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Microalgal drugs: A promising therapeutic reserve for the future

Cited by 31 publications

References 188 publications

Characterization of Neochloris oleoabundans under Different Cultivation Modes and First Results on Bioactivity of Its Extracts against HCoV-229E Virus

Characterization of Neochloris oleoabundans under Different Cultivation Modes and First Results on Bioactivity of Its Extracts against HCoV-229E Virus

Exploring the Role of Carbon-Based Nanomaterials in Microalgae for the Sustainable Production of Bioactive Compounds and Beyond

Antiviral Effects and Mechanisms of Action of Water Extracts and Polysaccharides of Microalgae and Cyanobacteria

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