At present, most of the studies of the stability of the formation-cement sheath-casing combination have been mainly based on the plane, and the three-dimensional model established is only one example. There is no systematic study of the influence of physical parameters and process parameters on the stability of the combined body under the three-dimensional model and the action of triaxial crustal stress. Through the establishment of three-dimensional formation-cement sheath-casing linear elastic combination model, we can study the influence of operational parameters (cement sheath pressure, casing cross section pressure, inner casing pressure, ellipticity of borehole, centrality of casing, thickness of cement sheath) by the two interfaces’ Von Mises stress and the total displacement of the combination body. It is pointed out that the pressure of cement sheath, and casing cross section pressure have no effect on the stability of formation, cement sheath and casing; The higher the ellipticity of the borehole, the eccentricity of the casing (position 1, 2) and the thickness of the cement sheath, the higher the stability of the second interface of the cementing; The higher the inner casing pressure and the eccentricity of the casing(position 3), the lower the stability of the second interface of the cementing; The higher the eccentricity of the casing (position 2,3) and the thickness of the cement sheath, the higher the stability of the first interface of the cementing; The higher the inner casing pressure, the eccentricity of the casing (position 1) and the ellipticity of the borehole, the lower the stability of the first interface of the cementing; The higher the eccentricity of the casing (position 2,3) and thickness of the cement sheath, the higher the stability of the casing; The higher the inner casing pressure, the ellipticity of the borehole and the eccentricity of the casing(position 1), the lower the stability of the casing. Through this study, according to the formation stress, the formation physical parameters (elastic modulus, Poisson's ratio, density), optimize the operational parameters, ensure the long-term integrity of the combination.