Microarchitecture and Biomechanical Evaluation of BoneCeramic Grafted Alveolar Defects during Tooth Movement in Rat

Ru, Nan; Liu, Sean Shih-Yao; Bai, Yuxing; Li, Song; Liu, Yunfeng; Zhou, Guanjun

doi:10.1597/16-006

Cited by 10 publications

(36 citation statements)

References 19 publications

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“…These cleft defects are unique with regard to the associated soft-tissue connection of the oral and nasal mucosa. In this context, various experimental cleft models in rats have been used to investigate cleft repair techniques and grafting materials 12 – 20 . However, these models did not coincide with a clinical cleft, where the epithelium lining is defective.…”

Section: Discussionmentioning

confidence: 99%

“…Different rat models have been presented for cleft research 12 – 20 , but most models are not in accord with the clinical situation in which the defect is covered by the epithelial lining. In these cleft models the bone defect is created and filled in the same operation.…”

Section: Introductionmentioning

confidence: 99%

“…With regard to the cleft location in the rat models, a distinction is made between the mid-palate cleft in the anterior part of the maxilla 12 – 14 and the alveolar cleft in the central 13 , 15 , 16 or posterior 17 – 20 maxilla. The defects in the posterior part usually accompany extraction; that is, they are more like large extraction defects than complete interruptions of the alveolar ridge continuity as per the meaning of a cleft.…”

Section: Introductionmentioning

confidence: 99%

“…However, the researchers did not compare autografts with other kinds of grafting materials. In this context, Ru et al compared a synthetic bone substitute based on a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) with a bovine xenograft in a corresponding alveolar defect model in rats 20 . They found the least amount of tooth movement, volumes and craters of root resorption, and the highest bone volume fraction (BV/TV), trabecular number, and mean trabecular thickness in the synthetic bone group 19 .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Möhlhenrich

Kniha

Magnuska

et al. 2021

Sci Rep

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To minimize the postoperative risks posed by grafting autologous transplants for cleft repair, efforts are being made to improve grafting materials for use as potential alternatives. The aim of this study was to compare the bone graft quality of different bone substitutes including the gold standard autografts during the healing processes after cleft repair in the context of orthodontic treatment. In 21 Wistar rats, a complete, continuity-interrupting cleft was created. After 4 weeks, cleft repair was performed using autografts from the hips’ ischial tuberosity, human xenografts, or synthetic bone substitutes [beta-tricalcium phosphate (β-TCP)/hydroxyapatite (HA)]. After another 4 weeks, the first molar movement was initiated in the reconstructed jaw for 8 weeks. The bone remodeling was analyzed in vivo using micro-computed tomography (bone mineral density and bone volume fraction) and histology (new bone formation). All the grafting materials were statistically different in bone morphology, which changed during the treatment period. The β-TCP/HA substitute demonstrated less resorption compared to the autologous and xenogeneic/human bone, and the autografts led to a stronger reaction in the surrounding bone. Histologically, the highest level of new bone formation was found in the human xenografts, and the lowest was found in the β-TCP/HA substitute. The differences between the two bone groups and the synthetic materials were statistically significant. Autografts were confirmed to be the gold standard in cleft repair with regard to graft integration. However, parts of the human xenograft seemed comparable to the autografts. Thus, this substitute could perhaps be used as an alternative after additional tissue-engineered modification.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Möhlhenrich

Kniha

Magnuska

et al. 2021

Sci Rep

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“…Hence, TCP graft has shown several potentials to be used as a substitution of autograft materials instead. 5 TCP grafts have also been widely used by orthopedic surgeons to repair bone defects in certain clinical conditions. Leucht P et al showed that there were no significant differences of functional scores between the use of TCP graft and autograft in repairing acetabulum fractures with marginal impaction.…”

Section: Discussionmentioning

confidence: 99%

Cancellous Bone Versus Tricalcium Phospate (TCP) For Bone Grafting: A Literature Review And Case Report Of Alveolar Bone Grafting In Cipto Mangunkusumo Hospital

Maulana¹,

Primadian²,

Pancawati³

et al. 2018

J Plast Rekons

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Background: In the last decade, there are various methods of bone grafting in plastic surgery. Cancellous bone is more often used as bone graft than cortical bone due to its high osteoconductivity and osteogenic capability. The synthetic materials for bone graft such as tricalcium phospate (TCP) and hydroxy-apatite can be use as new alternative for bone grafting surgery. Methods: The PubMed® databases were searched using the terms: ‘bone graft OR bone grafting’ AND ‘cancellous bone OR iliac crest OR tibia’ AND ‘tricalcium phospate OR tricalciumphospate OR tri calcium phospate’, restricted to English language, and to a publication period from January 2010 to January 2017. The inclusion criteria were any kind of research paper that compared the utility of TCP synthetic graft and autograft as a bone graft. Results: Out of 139 selected studies, only 8 met the inclusion criteria. In 6 publications TCP graft has similar outcome and in 1 publication have a better result in reducing post operative complication. Conclusion: TCP graft can be used as substitution for autograft in particular clinical conditions and surgical methods.

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Development of root resorption during orthodontic tooth movement after cleft repair using different grafting materials in rats

et al. 2022

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Objective The aim of the present study was to investigate the influence of three grafting materials for cleft repair on orthodontic tooth movement in rats. Materials and methods Artificial alveolar clefts were created in 21 Wistar rats and were repaired 4 weeks later using autografts, human xenografts and synthetic bone substitute (beta-tricalcium phosphate/hydroxyapatite [β-TCP/HA]). A further 4 weeks later, the first molar was moved into the reconstructed maxilla. Microfocus computed tomography (μCT) was performed six times (T0–T5) to assess the tooth movement and root resorption. After 8 weeks, the affected reconstructed jaw was resected for histopathological investigation. Results Total distances reached ranged from 0.82 ± 0.72 mm (β-TCP/HA) to 0.67 ± 0.27 mm (autograft). The resorption was particularly determined at the mesiobuccal root. Descriptive tooth movement slowed and root resorption increased slightly. However, neither the radiological changes during tooth movement (µCT T1 vs. µCT T5: autograft 1.85 ± 0.39 mm3 vs. 2.38 ± 0.35 mm3, p = 0.30; human xenograft 1.75 ± 0.45 mm3 vs. 2.17 ± 0.26 mm3, p = 0.54; β-TCP/HA: 1.52 ± 0.42 mm3 vs. 1.88 ± 0.41 mm3, p = 0.60) nor the histological differences after tooth movement (human xenograft: 0.078 ± 0.05 mm2; β-TCP/HA: 0.067 ± 0.049 mm2; autograft: 0.048 ± 0.015 mm2) were statistically significant. Conclusion The autografts, human xenografts or synthetic bone substitute used for cleft repair seem to have a similar effect on the subsequent orthodontic tooth movement and the associated root resorptions. Clinical relevance Development of root resorptions seems to have a secondary role in choosing a suitable grafting material for cleft repair.

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Microarchitecture and Biomechanical Evaluation of BoneCeramic Grafted Alveolar Defects during Tooth Movement in Rat

Abstract: BoneCeramic has better osteoconductive potential and biomechanical properties and induces less root resorption compared with Bio-Oss grafting and naturally recovered extraction site.

Cited by 10 publications

References 19 publications

Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Cancellous Bone Versus Tricalcium Phospate (TCP) For Bone Grafting: A Literature Review And Case Report Of Alveolar Bone Grafting In Cipto Mangunkusumo Hospital

Development of root resorption during orthodontic tooth movement after cleft repair using different grafting materials in rats

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