Microarray analysis of an synthetic α-synuclein induced cellular model reveals the expression profile of long non-coding RNA in Parkinson’s disease

Lin, Daixi; Liang, Yuhan; Jing, Xin; Chen, Y.; Lei, Meng-Qi; Zeng, Zhifen; Zhou, Tianshou; Wu, Xiaoyan; Peng, Sheng; Zheng, Duo; Huang, Kaixun; Liu, Yang; Xiao, Shuqi; Liu, J.; Tao, Enxiang

doi:10.1016/j.brainres.2017.11.007

Cited by 28 publications

(30 citation statements)

References 55 publications

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“…High‐throughput gene chip and sequencing screening results showed that a large number of lncRNAs are differentially expressed in brain tissues and peripheral blood of PD patients, PD animals, and cell models of PD, suggesting that lncRNAs are involved in the occurrence of PD. Abnormal expression of lncRNAs was observed in the early stages of PD . Preliminary functional studies confirmed that lncRNAs are involved in the occurrence and development of PD.…”

Section: Discussionmentioning

confidence: 74%

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc‐MKRN2‐42:1 in the pathogenesis of Parkinson's disease

et al. 2019

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Background: Parkinson's disease (PD) is a common movement disorder for which diagnosis mainly depends on the medical history and clinical symptoms. Exosomes are now considered an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids, and genetic material. Long noncoding (lnc) RNA in exosomes plays a critical role in many diseases, including neurodegenerative disease.Aim: To study expression differences for lncRNAs in peripheral blood exosomes of PD patients compared with healthy individuals and to look for lncRNAs that might be related to the pathogenesis of PD. Materials and Methods:We recruited PD patients along with age-and sex-matched healthy individuals as healthy controls and evaluated levels of lncRNAs extracted from exosomes in plasma samples via next-generation sequencing and real-time quantitative PCR. Correlation analysis was conducted for the clinical characteristics of PD patients and the expression of selected lncRNAs.

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Section: Discussionmentioning

confidence: 74%

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc‐MKRN2‐42:1 in the pathogenesis of Parkinson's disease

et al. 2019

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“…Similarly, PDrelated lncRNAs were also found in different PD animal and cell models. e SH-SY5Y cell line stimulated with alphasynuclein produced 53 upregulated lncRNAs and 69 downregulated lncRNAs compared with the control group [5]. e specific downregulation of AS Uchl1 in iMN9D cell lines stimulated with 1-methyl-4-phenylpyridinium (MPP+) was also verified [28].…”

Section: Aberrant Expression Of Lncrnas In Pdmentioning

confidence: 82%

“…Recent studies focus on the pathogenesis of PD at both the microscopic biological and macroscopic anatomical levels to find an effective therapy [5]. PD has a variety of pathophysiological mechanisms, including alpha-synuclein aggregate, mitochondrial dysfunction, oxidative stress, calcium homeostasis, axonal transport, and neuroinflammation [6].…”

Section: Introductionmentioning

confidence: 99%

Role of Long Noncoding RNAs in Parkinson’s Disease: Putative Biomarkers and Therapeutic Targets

Wang

Zhong

et al. 2020

Parkinson's Disease

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Parkinson’s disease (PD) is a neurodegenerative disease characterized by bradykinesia, rigidity, and tremor. Age is the main risk factor. Long noncoding RNAs (lncRNAs) are novel RNA molecules of more than 200 nucleotides in length. They may be involved in the regulation of many pathological processes of PD. PD has a variety of pathophysiological mechanisms, including alpha-synuclein aggregate, mitochondrial dysfunction, oxidative stress, calcium homeostasis, axonal transport, and neuroinflammation. Among these, the impacts of lncRNAs on the pathogenesis and progression of PD need to be highlighted. lncRNAs may serve as putative biomarkers and therapeutic targets for the early diagnosis of PD. This study aimed to investigate the role of lncRNAs in various pathological processes of PD and the specific lncRNAs that might be used as putative diagnostic biomarkers and therapeutic targets of PD.

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“…The relationship between lncRNA and PD is still unclear. Studies have found abnormal expression of lncRNAs in early PD [ 34 , 35 ], and antisense lncRNAs have been shown to regulate PD characteristics [ 36 ]. For example, NEAT1 lncRNA was found to inhibit the degradation of PINK1 protein, and interference with NEAT1 has been found to ameliorate damage to dopaminergic neurons [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-Scale Expression Pattern of Long Non-Coding RNAs in Chinese Uyghur Patients with Parkinson’s Disease

Wang

Gao

et al. 2020

Med Sci Monit

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Background Long non-coding RNAs (lncRNAs) are transcripts thought to regulate gene expression at the post-transcriptional level. Some lncRNAs are associated with Parkinson’s disease (PD) and participate in pathological processes of PD. The incidence of PD is relatively high in members of the Uyghur minority living in Xingjiang province of China. This study measured the expression of lncRNAs in the peripheral blood cells of Chinese Uyghur individuals with and without PD and analyzed the possible function of these lncRNAs in the development of PD. Material/Methods Peripheral blood samples were collected from 55 Uyghur patients with PD and 55 healthy volunteers. Total RNA was extracted, and the levels of expression of whole-genome lncRNAs and mRNAs in 10 samples (5 PD and 5 controls) were determined by microarray method. The expression levels of lncRNAs in all 100 subjects were determined by qRT-PCR. The lncRNA expression profiles of PD patients were determined based on lncRNA microarray chip analysis, and differentially expressed lncRNAs were identified. The results of chip analysis were confirmed in a large clinical cohort. Results Comparison of subjects with and without PD identified 32 significantly up-regulated and 18 significantly down-regulated lncRNAs in the PD group. GO analysis showed that mRNAs encoding proteins involved in the regulation of biological processes were differentially expressed, with the inflammatory immune response being the most significantly related pathway. Conclusions The expression of lncRNAs in peripheral blood differed significantly in PD patients and controls. These differentially expressed lncRNAs may play a role in the development of PD.

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Microarray analysis of an synthetic α-synuclein induced cellular model reveals the expression profile of long non-coding RNA in Parkinson’s disease

Cited by 28 publications

References 55 publications

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc‐MKRN2‐42:1 in the pathogenesis of Parkinson's disease

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc‐MKRN2‐42:1 in the pathogenesis of Parkinson's disease

Role of Long Noncoding RNAs in Parkinson’s Disease: Putative Biomarkers and Therapeutic Targets

Genome-Scale Expression Pattern of Long Non-Coding RNAs in Chinese Uyghur Patients with Parkinson’s Disease

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