Microarray analysis of the gene expression profile of HMC-1 mast cells following Schizonepeta tenuifolia Briquet treatment

(R)-(+)-pulegone suppresses allergic and inflammation responses on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice model

“…histamine release from rat peritoneal mast cells in type I allergic reactions [14]. Furthermore, pulegone treatment led to significant reduction of pro-inflammatory cytokines (IL-6, IL-8, and TNF-α) in PMA plus A23187-stimulatd HMC-1 human mast cells [24]. Consistent with the previous studies, our study showed that PLG decreased the number of mast cells in dermis and normalized the level of IgE in serum.…”

Immunomodulation Effects of Schizonepeta tenuifolia Briq. on the IgE‐Induced Allergic Model of RBL‐2H3 Cells

“…Finally, we found RBL-2H3 cells to be a feasible in vitro model to examine the mechanisms and effects of compounds on urticaria. In our study, the anti-inflammatory response in RBL-2H3 cells was like findings describing the response in the mast cell model, HMC-1 cells, as both systems showed the IL-6 and TNF- α suppression [ 19 , 21 ]. Although basophils and mast cells have different cellular origins, both cells are important in chronic urticaria for the release of histamine when exposed to the susceptible allergens [ 39 , 40 ].…”

“…Wang et al also presented the antioxidant and anti-inflammatory role of aqueous extracts of ST in the carrageenan-induced inflammatory response in mice, and the volatile oil from ST also can relieve carrageenan-induced pleurisy in rat [ 17 , 18 ]. ST also regulates cytokine-cytokine receptor interaction, MAPK, and Toll-like receptor (TLR) signaling pathways in HMC-1 mast cells [ 19 ]. Methanol extracts of ST inhibit the substance p-induced itch-scratch response in mice [ 20 ].…”

Blue Light–Induced Oxidative Stress in Human Corneal Epithelial Cells: Protective Effects of Ethanol Extracts of Various Medicinal Plant Mixtures

“…japonica Kitagawa is generally accepted to have antioxidant and antiinflammatory effects, which may be related to the reduction of ROS and the increase in the activities of antioxidant enzymes. [35][36][37][38][39] Angelica dahurica Bentham ET hooker upregulates HO-1 expression and suppresses the NF-jB pathway, and it has been used to treat oxidative stress-related inflammatory diseases such as asthma. 40,41 In addition, Rehmannia glutinosa increases the activities of antioxidant enzymes and have potential as a preventive treatment for oxidative stress-mediated diseases.…”