Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients

Shimizu, Taro; Kubota, Takehiko; Nakasone, Naohiro; Abe, Daisuke; Morozumi, Toshiya; Yoshie, Hiromasa

doi:10.1016/j.archoralbio.2010.10.002

Cited by 13 publications

(13 citation statements)

References 42 publications

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“…11 Several MMPs are expressed in bone function in endochondral ossification during embryonic development and in the modeling and remodeling of bone postnatally and later in life. 10 MMPs act in the degradation of the bone extracellular matrix 12 , and their expression is frequently induced by cytokines with bone-resorbing activity such as interleukin (IL)-1 and IL-6. 13 MMP7 upregulation that we found, support the knowledge of previous functional studies.…”

Section: Discussionmentioning

confidence: 99%

“…Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer 8 , asthma 9 , rheumatoid disorders 10,11 and periodontitis 12 , and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of AgP and generate further information other than clinical signs and symptoms of AgP.…”

mentioning

confidence: 99%

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Gene‐Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network‐Based Microarray Analysis

Güzeldemir-Akçakanat

Sunnetci‐Akkoyunlu

Orucguney

et al. 2016

Journal of Periodontology

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Functions of the identified genes that were involved in gene networks were cellular development, cell growth and proliferation, cellular movement, cell-cell signaling and interaction, humoral immune response, protein synthesis, cell death and survival, cell population and organization, organismal injury and abnormalities, molecular transport, and small-molecule biochemistry. The data suggest new networks that have important functions as humoral immune response and organismal injury/abnormalities. Future analyses may facilitate proteomic profiling analyses to identify gene-expression patterns related to clinical outcome.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Gene‐Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network‐Based Microarray Analysis

Güzeldemir-Akçakanat

Sunnetci‐Akkoyunlu

Orucguney

et al. 2016

Journal of Periodontology

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“…; Shimizu et al . ). The results of the current study revealed not only the association between CaCBs and periodontitis but also that β antagonists and polystyrene sulphonate could contribute to the development of periodontitis.…”

Section: Discussionmentioning

confidence: 97%

Could drug burden be associated with severe periodontitis in patients receiving haemodialysis?

Yeter

Erten

İşler

et al. 2019

Journal of Renal Care

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SUMMARY Background Periodontitis increases the risk of cardiovascular disease in the general population by triggering systemic inflammation. Aim To investigate the relationship between systemic inflammation and periodontitis, and clarify any association between severe periodontitis and the medications used by patients receiving haemodialysis. Design A cross‐sectional study. Participants The study was undertaken with 56 patients receiving haemodialysis. Measurements Demographic and laboratory data and prescribed drugs regularly used by patients were recorded from hospital records. During the dialysis session, a validated Xerostomia Inventory score was completed. A complete dental/periodontal examination was also undertaken on all patients by the same periodontist. Results In the study population, stage I periodontitis was determined in 41%, stage II periodontitis in 17%, stage III periodontitis in 21%, and stage IV periodontitis in 21%. Male gender, hypertension, coronary artery disease, β antagonists, calcium channel blockers, sodium polystyrene sulphonate, teeth brushing less than twice a day and high sensitive C‐reactive protein > 8 mg/l were significantly associated with severe periodontitis. Conclusion Drugs, including β antagonists, calcium channel blockers, polystyrene sulphonate, co‐morbid conditions and poor or insufficient oral care could facilitate an increase in the severity of periodontitis in patients receiving haemodialysis. Severe periodontitis also seems to be associated with cardiovascular disease and inflammation in patients with chronic renal disease.

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“…Many investigations, in this regard, indicate that Cathepsin L appears to be one of the key enzymes involved in the pathogenesis of this pathological condition [15,64,65,[112][113][114]. This hypothesis is sustained by immunohistochemical and biochemical observations, which show that Cathepsin L is colocalized with Cathepsin B in both rat and human gingival fibroblasts and that the activity levels of these proteinases in gingival tissue homogenates are significantly higher in tissue from chronic periodontitis patients than in healthy gingiva [15,64,65,[112][113][114][115]. In addition, in these patients, a positive correlation can be observed between Cathepsin L/B activity levels and gingival inflammation, probing-depth, probing attachment level and bone loss [15,64,65].…”

Section: Cathepsin L In Periodontal Diseasesmentioning

confidence: 88%

“…These data indicate that Cathepsin L may be implicated in the collagen degradation during orthodontic tooth movement. On the other hand, microarray and quantitative RT-PCR analyses carried out by Shimuzu et al [115] on overgrowth tissue from periodontitis patients with calciumchannel blocker-induced gingival overgrowth show that Cathepsin L was significantly up-regulated in tissue from these patients when compared with control gingival tissue from healthy subjects. These data are in line with previous results from microarray analysis by Ryder et al [116], showing that Cathepsin L gene expression is significantly more elevated (twofold, on average) in peripheral mononuclear blood cells exposed to tobacco smoke than in cells isolated from healthy non-smoker subjects.…”

Section: Cathepsin L In Periodontal Diseasesmentioning

confidence: 96%

Cathepsin L in Normal and Pathological Bone Remodeling

Leto

Crescimanno

Flandina

et al. 2011

Clinic Rev Bone Miner Metab

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Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes including bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeostasis and, eventually, in the onset of pathological conditions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone diseases. This review provides insight into the most recent advances in understanding the role of Cathepsin L in normal and pathological bone remodeling and discusses the potential clinical and therapeutic applications related to these findings.

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Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients

Cited by 13 publications

References 42 publications

Gene‐Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network‐Based Microarray Analysis

Gene‐Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network‐Based Microarray Analysis

Could drug burden be associated with severe periodontitis in patients receiving haemodialysis?

Cathepsin L in Normal and Pathological Bone Remodeling

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