2014
DOI: 10.1186/1471-2334-14-332
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Microarray of surface-exposed proteins of rickettsia heilongjiangensisfor serodiagnosis of Far-eastern spotted fever

Abstract: BackgroundFar-eastern spotted fever (FESF) is an important emerging infectious disease in Northeast Asia. The laboratory diagnosis of FESF in hospitals is mainly based on serological methods. However, these methods need to cultivate rickettsial cells as diagnostic antigens, which is both burdensome and dangerous.MethodsEleven surface-exposed proteins (SEPs) were identified in our previous study and their recombinant proteins (rSEPs) fabricated on a microarray were serologically analyzed with seventeen paired s… Show more

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Cited by 5 publications
(2 citation statements)
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“…It has been identified to be an SEP in both R. felis [5] and R. heilongjiangensis [3]. Further, it could react with sera from R. heilongjiangensis -infected mice or from patients and was considered a candidate diagnostic reagent [3, 24]. Considering the opposing views of subcellular location and the importance of this antigen, we confirmed its subcellular location by bioinformatics tools as well as by immunoelectron microscopy.…”
Section: Discussionmentioning
confidence: 55%
“…It has been identified to be an SEP in both R. felis [5] and R. heilongjiangensis [3]. Further, it could react with sera from R. heilongjiangensis -infected mice or from patients and was considered a candidate diagnostic reagent [3, 24]. Considering the opposing views of subcellular location and the importance of this antigen, we confirmed its subcellular location by bioinformatics tools as well as by immunoelectron microscopy.…”
Section: Discussionmentioning
confidence: 55%
“…In mainland China, at least 18 species of Candidatus species of SFGR have been referred to as human pathogens, and 8 of them have been confirmed: including R. heilongjiangensis , R. japonica , R. raoultii , R. sibirica , R. monacensis , Candidatus R. tarasevichiae, R. XY99 , and Ca . R. xinyangensis [ 3 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. In the genus Anaplasma and the genus Ehrlichia, which belong to Anaplasmatacae, A. phagocytophilum and E. chaffeensis were the causative agents of well-known tick-borne diseases: human granulocytic anaplasmosis (HGA), and human monocytic ehrlichiosis (HME), respectively.…”
Section: Introductionmentioning
confidence: 99%