Microarray patches: scratching the surface of vaccine delivery

Choo, Jovin J. Y.; McMillan, Christopher L. D.; Young, Paul R.; Muller, David A.

doi:10.1080/14760584.2023.2270598

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2024

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Cited by 7 publications

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“…This places the HD-MAP as an ideal candidate for vaccine delivery in a pandemic context, where delays in seroconversion could result in increased infections. It is worth noting that acceptability and usability of HD-MAP vaccines in the public domain relative to IM injection is a topic that requires further investigation before widespread MAP usage can become a reality (reviewed in [12]).…”

Section: Discussionmentioning

confidence: 99%

Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein

McMillan,

Wijesundara,

Choo

et al. 2024

Journal of General Virology

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The COVID-19 pandemic has highlighted the need for vaccines capable of providing rapid and robust protection. One way to improve vaccine efficacy is delivery via microarray patches, such as the Vaxxas high-density microarray patch (HD-MAP). We have previously demonstrated that delivery of a SARS-CoV-2 protein vaccine candidate, HexaPro, via the HD-MAP induces potent humoral immune responses. Here, we investigate the cellular responses induced by HexaPro HD-MAP vaccination. We found that delivery via the HD-MAP induces a type one biassed cellular response of much greater magnitude as compared to standard intramuscular immunization.

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Section: Discussionmentioning

confidence: 99%