Microbe-host interplay in atopic dermatitis and psoriasis

Fyhrquist, Nanna; Muirhead, Gareth; Prast‐Nielsen, Stefanie; Jeanmougin, M.; Oláh, Péter; Skoog, Tiina; Jules-Clément, Gérôme; Feld, M; Barrientos‐Somarribas, Mauricio; Sinkko, Hanna; Bogaard, Ellen H. van den; Zeeuwen, Patrick L.J.M.; Rikken, Gijs; Schalkwijk, Joost; Niehues, Hanna; Däubener, Walter; Eller, Silvia Kathrin; Alexander, H; Pennino, Davide; Suomela, Sari; Tessas, Ioannis; Lybeck, Emilia; Baran, Anna; Darban, Hamid; Gangwar, Roopesh Singh; Gerstel, Ulrich; Jähn, Katharina; Karisola, Piia; Lu, Yan; Hansmann, Britta; Katayama, Shintaro; Meller, Stephan; Bylesjö, Max; Hupé, Philippe; Levi‐Schaffer, Francesca; Greco, Dario; Ranki, Annamari; Schröder, Jens-Michael; Barker, Jonathan; Kere, Juha; Tsoka, Sophia; Lauerma, Antti; Soumelis, Vassili; Nestle, Frank O.; Homey, Bernhard; Andersson, Björn; Alenius, Harri

doi:10.1038/s41467-019-12253-y

Cited by 251 publications

(280 citation statements)

References 69 publications

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“…In contrast, the skin microbiome of AD patients was highly over-represented by Staphylococcus (S.) aureus which allowed the discrimination of a S. aureus "low" and "high" colonized state. The latter one was shown to be paralleled by increased barrier dysfunction (e.g., CLDN8, FLG) and a stronger immune cell related profile (e.g., IL13, IL5) [148,151]. This identified "high" colonized state may also be more prone to HSV-1 infections as it is seen in ADEH+ patients [88].…”

Section: Disease Subgroupingmentioning

confidence: 88%

“…As skin is a major body site directed toward environmental impacts, the microbiome is a crucial player in the tissue homeostasis and fine-tuned regulation between immune activation and tolerance is necessary [147]. A recent study revealed the existence of different endotypes according to the microbiome and revealed a high diversity of microbial species in psoriatic skin [148,149]. As dysregulated EDC members often show antimicrobial activity (e.g., S100s and LECs), the investigation of the microbiome in dependency of genetic mutations would be intriguing [150].…”

Section: Disease Subgroupingmentioning

confidence: 99%

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Review—Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis

Schwingen

Kaplan

Kurschus

2020

IJMS

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During the last decades, high-throughput assessment of gene expression in patient tissues using microarray technology or RNA-Seq took center stage in clinical research. Insights into the diversity and frequency of transcripts in healthy and diseased conditions provide valuable information on the cellular status in the respective tissues. Growing with the technique, the bioinformatic analysis toolkit reveals biologically relevant pathways which assist in understanding basic pathophysiological mechanisms. Conventional classification systems of inflammatory skin diseases rely on descriptive assessments by pathologists. In contrast to this, molecular profiling may uncover previously unknown disease classifying features. Thereby, treatments and prognostics of patients may be improved. Furthermore, disease models in basic research in comparison to the human disease can be directly validated. The aim of this article is not only to provide the reader with information on the opportunities of these techniques, but to outline potential pitfalls and technical limitations as well. Major published findings are briefly discussed to provide a broad overview on the current findings in transcriptomics in inflammatory skin diseases.

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Section: Disease Subgroupingmentioning

confidence: 88%

Section: Disease Subgroupingmentioning

confidence: 99%

Review—Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis

Schwingen

Kaplan

Kurschus

2020

IJMS

View full text Add to dashboard Cite

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“…In terms of cutaneous pathophysiology, shifts in the composition of the cutaneous microbiome (dysbiosis) have been identified in a range of inflammatory and autoimmune conditions including psoriasis [49][50][51][52], atopic eczema [53][54][55], bullous pemphigoid [56,57] and acne vulgaris [58]. Building on the evidence from culture-based studies that HS is associated with dysbiosis, Guet-Revillet et al [59] employed both culture and metagenomic techniques to comprehensively characterise the cutaneous microbiome in HS.…”

Section: The Benefits Of 16s Rrna Sequencing and Metagenomic Approachesmentioning

confidence: 99%

The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel

Langan

Recke

Bokor-Billmann

et al. 2020

IJMS

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The development of next generation sequencing, coupled with advances in bio-informatics, has provided new insights into the role of the cutaneous microbiome in the pathophysiology of a range of inflammatory skin diseases. In fact, it has even been suggested that the identification of specific skin microbial signatures may not only be useful in terms of diagnosis of skin diseases but they may also ultimately help inform personalised treatment strategies. To date, research investigating the role of microbiota in the development of inflammatory skin diseases has largely focused on atopic eczema and psoriasis vulgaris. The role of the microbiome in Hidradenits suppurativa (HS)-also known as acne inversa-a chronic auto-inflammatory skin disease associated with significant morbidity, has received comparatively little attention. This is despite the fact that antimicrobial therapy plays a central role in the treatment of HS. After briefly outlining the clinical features of HS and current treatment strategies, we move on to review the evidence of microbial dysbiosis in HS pathophysiology. We conclude by outlining the potential for metagenomic studies to deepen our understanding of HS biology but more importantly to identify novel and much needed treatment strategies.scoring and the HS severity index. Whilst the precise incidence and prevalence of HS is unclear [8], due partly to the diagnostic difficulty associated with HS and the use of both registry data and self-report questionnaires [9]. Garg et al. reported a prevalence of 0.1% in a US-based population analysis, leading the authors to conclude that HS is an uncommon but not rare disease, with over-representation in young, female and African American patients [10]. The current multi-modal treatment approach includes the use of intralesional steroids, surgical and laser therapy, topical and systemic medical antimicrobial therapy and biologic treatments [11].Sartorius scoring and the HS severity index. Whilst the precise incidence and prevalence of HS is unclear [8], due partly to the diagnostic difficulty associated with HS and the use of both registry data and self-report questionnaires [9]. Garg et al. reported a prevalence of 0.1% in a US-based population analysis, leading the authors to conclude that HS is an uncommon but not rare disease, with over-representation in young, female and African American patients [10]. The current multi-modal treatment approach includes the use of intralesional steroids, surgical and laser therapy, topical and systemic medical antimicrobial therapy and biologic treatments [11].

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“…Currently, exploration of the skin microbiome in AD is attracting more and more attention from researchers. Dysbiosis in microbiota has been universally considered an important factor in the pathogenesis of AD, and how to achieve and maintain a balance between skin microbiota and the host has become a hot research topic in the field of AD treatment [10]. Although traditional treatments including topical glucocorticoid and calcineurin inhibitors can inhibit inflammation, the recurrence of AD continues.…”

Section: Introductionmentioning

confidence: 99%

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Wan

Chen

2020

Dermatol Ther (Heidelb)

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Atopic dermatitis (AD) is a chronic common inflammatory skin disorder with clinical characteristics of pruritic, dry, and recurrent flares that involve the whole body. Recent studies have demonstrated that the skin microbiota, characterized by an overgrowth of Staphylococcus aureus (S. aureus), plays a critical role in the manifestation of AD. There is striking evidence that skin microbiota can modulate the development and progression of AD. Therefore, more and more therapeutic approaches are adopted for modifying skin microbiota. Here we discuss the role of skin microbiota in the etiology and maintenance of AD; furthermore, we summarize the effects of therapeutic treatments on skin microbiota in AD based on published literature. With the help of the theoretical guidance suggested by microbial metagenome analysis, the reconstitution of microbiota should be a promising way to harness the pathogens of AD and could be used as a brandnew therapeutic strategy in clinical trials. We believe that the targeted therapy of dysbiosis in AD may possibly become a unique approach to an integrated treatment program in the near future.

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Microbe-host interplay in atopic dermatitis and psoriasis

Cited by 251 publications

References 69 publications

Review—Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis

Review—Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis

The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

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