Microbead design for sustained drug release using four natural gums

Odeku, Oluwatoyin A.; Okunlola, Adenike; Lamprecht, Alf

doi:10.1016/j.ijbiomac.2013.03.049

Cited by 38 publications

(33 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A blend of alginate, locust bean gum and xanthan gum in fabrication of microspheres enhanced drug entrapment efficiency and further retarded drug release in comparison to the use of alginate and locust bean or alginate and xanthan gum [47]. Microbeads fabricated with a blend of alginate and irvingia gum significantly enhanced drug entrapment efficiency and controlled the release of diclofenac sodium over 7 h in comparison to microbeads fabricated with alginate alone [48]. Blends of natural and synthetic gums such as carboxymethyl cellulose/locust bean gum and methacrylate copolymer [49] to produce hydrogels have also been undertaken.…”

Section: Polymer-polymer Blendingmentioning

confidence: 99%

“…In summary, mucuna polymer holds promise as a micro-and nano-carrier and should be further investigated. In addition, plant polymers such as cissus gum (Cissus pulpunea), khaya gum (Khaya grandifoliola), irvingia gum (Irvingia gabonensis) and albizia gum (Albizia zygia) have been blended with sodium alginate to fabricate microbeads [48]. Indeed more use of plant polymers for nano drug delivery is encouraged.…”

Section: Natural Polymers For Micro-and Nano Drug Carriersmentioning

confidence: 99%

See 1 more Smart Citation

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

2014

View full text Add to dashboard Cite

Naturapolyceutics defines the emerging science and technology platform that blends natural polymers and pharmaceutics for the design and development of drug delivery systems. Natural polymers due to their biological properties, sustainability, chemical flexibility, human and eco-friendliness are promising in this field. As drug delivery advances, there will be need for more polymers. Given that polymers utilized in pharmaceuticals require regulatory approval, robust processes are undertaken to facilitate the production of pharmaceutical grade natural polymers. This review provides insight into the processes-extraction, purification, modifications and characterizations-involved in the eventual utilization of natural polymers for drug delivery. The versatility of natural polymers and particularly modified natural polymers in targeted drug delivery, micro-/nano-drug delivery, theranostics, BioMEMs and generally in research and development of highly efficient, safe and quality products is demonstrated. Natural polymers are polymers of today and tomorrow. Therefore, the shift to undertake training, extensive research and subsequent commercialization of more natural polymers-novel and underutilized-for drug delivery is now!

show abstract

Section: Polymer-polymer Blendingmentioning

confidence: 99%

Section: Natural Polymers For Micro-and Nano Drug Carriersmentioning

confidence: 99%

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

2014

View full text Add to dashboard Cite

show abstract

“…However, their cell culture studies (in L929 cells) demonstrated noncytotoxicity of the formulated discs that makes them a strong candidate for nucleus pulposus regeneration (Pereira et al 2011). Odeku et al (2013) recently investigated four natural gums, viz., albizia, cissus, irvingia, and khaya gums, to develop microbeads for the controlled delivery of diclofenac sodium. Gel blends of natural gums and sodium alginate at different ratios were tested.…”

Section: Microparticulate Systemsmentioning

confidence: 99%

Pharmaceutical Applications of Various Natural Gums

Deshmukh¹,

Aminabhavi²

2014

Polysaccharides

View full text Add to dashboard Cite

Gums are the important ingredients in many pharmaceutical preparations owing to their biodegradability, abundant availability, non-toxicity, and low cost. In today's scenario, these are competing with many synthetic polymers for use as various pharmaceutical products and have made a remarkable journey from just being an excipient to novel drug delivery carriers. Particularly, the better understanding of their physiochemical properties and establishment of safety profile data has attracted researchers and pharmaceutical industries worldwide to unveil the hidden potential of natural gums. Although modification of natural gums has generated the entirely new class of polymeric materials useful in advanced drug delivery applications, exploration of natural gums in the design for development of nanomedicine and gene therapy has widened their applications as novel delivery materials. In this chapter, we have highlighted both basic and novel pharmaceutical applications of natural gums along with their future potential.

show abstract

“…Furthermore, they form microbeads, which have cracked and porous surfaces that can lead to relatively fast diffusion of moisture and other fluids, thus reducing the barrier properties in unfavorable environmental conditions [10]. Blending alginate with natural polymers such as gums and starches is a recent innovation that has been shown to be effective in overcoming many of these limitations by enhancing encapsulation efficiency and drug release properties of microbeads [4,[11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Cissus gum is popularly referred to as food gum with a wide range of local applications in Africa where it is used as soup thickener and remedy for indigestion [14]. Cissus gum is a hydrophilic polysaccharide that swells rapidly in cold water and a 2% dispersion has been shown to attain a viscosity of 11.6 Pa s. It has a particle density of 1.59 g cm 3 and glass transition temperature of 264.2 • C [12]. The gum has been evaluated as a binder in pharmaceutical tablets where it was reported to produce tablets with high mechanical strength and slow drug release properties [15].…”

Section: Introductionmentioning

confidence: 99%