Microbial amino acids production

Mahmood, Zafar

doi:10.1201/b17587-10

Cited by 9 publications

(6 citation statements)

References 40 publications

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“…In addition, new amino acids such as serine, glycine, threonine, arginine, alanine and valine were produced in both juices, although at low concentrations but probably with an additive effects against B. cinerea growth. Not all organisms are able to synthesize amino acids despite this feature being highly prominent and specific and exploited in different industrial requirements, such as glutamic acid widely used in recent years for its extensive application in the food industry (Mahmood, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effect of Aureobasidium pullulans strains against Botrytis cinerea on kiwifruit during storage and on fruit nutritional composition

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Effect of Aureobasidium pullulans strains against Botrytis cinerea on kiwifruit during storage and on fruit nutritional composition

et al. 2018

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“…As an essential building block for protein synthesis, l -lysine is an industrially important substance for animal feed and dietary supplements. Owing to global increases in meat consumption, l -lysine is particularly required for the animal feed market; the global market for l -lysine is expected to reach USD 6.96 billion by 2020 3 . Furthermore, meso -diaminopimelate ( d , l -DAP; m DAP), the intermediate precursor of l -lysine, is involved in cross-linking of the peptidoglycan cell wall of certain species of Gram-negative bacteria 4 .…”

mentioning

confidence: 99%

Structural basis for redox sensitivity in Corynebacterium glutamicum diaminopimelate epimerase: an enzyme involved in l-lysine biosynthesis

Sagong

Kim

2017

Sci Rep

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Diaminopimelate epimerase (DapF) is one of the crucial enzymes involved in l-lysine biosynthesis, where it converts l,l-diaminopimelate (l,l-DAP) into d,l-DAP. DapF is also considered as an attractive target for the development of antibacterial drugs. Here, we report the crystal structure of DapF from Corynebacterium glutamicum (CgDapF). Structures of CgDapF obtained under both oxidized and reduced conditions reveal that the function of CgDapF is regulated by redox-switch modulation via reversible disulfide bond formation between two catalytic cysteine residues. Under oxidized condition, two catalytic cysteine residues form a disulfide bond; these same cysteine residues exist in reduced form under reduced condition. Disulfide bond formation also induces a subsequent structural change in the dynamic catalytic loop at the active site, which results in open/closed conformational change at the active site. We also determined the crystal structure of CgDapF in complex with its product d,l-DAP, and elucidated how the enzyme recognizes its substrate l,l-DAP as a substrate. Moreover, the structure in complex with the d,l-DAP product reveals that CgDapF undergoes a large open/closed domain movement upon substrate binding, resulting in a completely buried active site with the substrate bound.

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“…Provision of AAs to vulnerable populations in the 21st century is possible through routes other than consumption of foods with different protein content. Individual AAs can be made commercially in an economical manner by chemical synthesis and genetic engineering of microorganisms (24), and these individual AAs can be added as supplements to basic foodstuffs, similar to micronutrient supplementation of cereal flours. Altering the populations of the gut microbiota to enhance the synthesis of essential AAs, which would then be absorbed, is another route via which AAs might be delivered to humans outside of food (25).…”

Section: Discussionmentioning

confidence: 99%

Serum Amino Acid Concentrations in Infants from Malawi are Associated with Linear Growth

Ordiz

Semba

Moaddel

et al. 2019

Current Developments in Nutrition

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Serum amino acid (AA) concentrations are correlated with childhood stunting, but their relation to linear growth velocity has not been explored. This was a secondary analysis of a clinical trial where Malawian infants aged 6–12 mo were given a legume supplement providing 8.2 g/d of protein; anthropometry was conducted at multiple intervals, and fasted serum AA concentrations were measured at 12 mo of age. Lysine, proline, tryptophan, tyrosine, and valine concentrations were higher in infants with a linear growth velocity z-score >0 than those <0. Corrected Spearman correlation coefficients between individual AA concentrations and weight-for-height and length velocity from 6 to 12 mo of age were positively correlated for glycine, isoleucine, proline, serine, threonine, tyrosine, and valine. Additionally, weight-for-height was correlated with arginine, asparagine, glutamine, leucine, lysine, methionine, and phenylalanine. The observed associations suggest that testing the hypothesis that essential AA provision will reduce linear growth faltering is warranted. This trial was registered at clinicaltrials.gov as NCT02472262.

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Microbial amino acids production

Cited by 9 publications

References 40 publications

Effect of Aureobasidium pullulans strains against Botrytis cinerea on kiwifruit during storage and on fruit nutritional composition

Effect of Aureobasidium pullulans strains against Botrytis cinerea on kiwifruit during storage and on fruit nutritional composition

Structural basis for redox sensitivity in Corynebacterium glutamicum diaminopimelate epimerase: an enzyme involved in l-lysine biosynthesis

Serum Amino Acid Concentrations in Infants from Malawi are Associated with Linear Growth

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