Microbial and Bioconversion Production of D-xylitol and Its Detection and Application

Chen, Xi; Jiang, Zi‐Hua; Chen, Sanfeng; Khatiwada, Janak Raj

doi:10.7150/ijbs.6.834

Cited by 112 publications

(48 citation statements)

References 83 publications

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“…In addition, studies have shown that xylitol prevents osteoporosis, haemolytic anaemia and acute otitis (Mussatto and Roberto 2002). Xylitol can be produced by the chemical reduction of D-xylose derived mainly from lignocellulose biomass hydrolysates (Chen et al 2010;da Silva and Chandel 2012;Mohamad et al 2015). However, the requirement for several purification steps to separate xylitol from other polyols and sugars during the chemical process increases the production cost.…”

Section: Introductionmentioning

confidence: 98%

Xylitol production by yeasts isolated from rotting wood in the Galápagos Islands, Ecuador, and description of Cyberlindnera galapagoensis f.a., sp. nov.

Guamán-Burneo

Dussán

Cadete

et al. 2015

Antonie van Leeuwenhoek

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This study evaluated D-xylose-assimilating yeasts that are associated with rotting wood from the Galápagos Archipelago, Ecuador, for xylitol production from hemicellulose hydrolysates. A total of 140 yeast strains were isolated. Yeasts related to the clades Yamadazyma, Kazachstania, Kurtzmaniella, Lodderomyces, Metschnikowia and Saturnispora were predominant. In culture assays using sugarcane bagasse hemicellulose hydrolysate, Candida tropicalis CLQCA-24SC-125 showed the highest xylitol production, yield and productivity (27.1 g L(-1) xylitol, Y p/s (xyl) = 0.67 g g(-1), Qp = 0.38 g L(-1). A new species of Cyberlindnera, strain CLQCA-24SC-025, was responsible for the second highest xylitol production (24 g L(-1), Y p/s (xyl) = 0.64 g g(-1), Qp = 0.33 g L(-1) h(-1)) on sugarcane hydrolysate. The new xylitol-producing species Cyberlindnera galapagoensis f.a., sp. nov., is proposed to accommodate the strain CLQCA-24SC-025(T) (=UFMG-CM-Y517(T); CBS 13997(T)). The MycoBank number is MB 812171.

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Section: Introductionmentioning

confidence: 98%

Xylitol production by yeasts isolated from rotting wood in the Galápagos Islands, Ecuador, and description of Cyberlindnera galapagoensis f.a., sp. nov.

Guamán-Burneo

Dussán

Cadete

et al. 2015

Antonie van Leeuwenhoek

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“…Hence, the production of secondgeneration bioethanol has allowed the use of these biomasses in its production, which guarantees high selectivity of the product, low cost and safety (Chen et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Bioconversion of hydrolyzed cashew peduncle bagasse for ethanol and xylitol production

Medeiros

Silva

Santos

et al. 2017

Rev. bras. eng. agríc. ambient.

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The agro-industrial waste deposited in the environment causes problems in nature that can be solved with the use and generation of bioproducts. Thus, the objective was to study the lignocellulosic fraction of cashew (Anacardium occidentale L.) peduncle bagasse and fermentation on large scale (8-16 times) using the strain Candida guilliermondii CCT-3544 as production agent. According to the obtained results, it can be noted that the dry cashew peduncle bagasse has 21.45% of cellulose, 10.96% of hemicellulose and 35.39% of lignin. During fermentation, C. guilliermondii 3544-CAT was able to grow on medium containing hydrolysate, with maximum cell growth concentration of 3.5 g L-1. The behavior of the sugars in the fermentation process was similar in the different variables, with maximum production of ethanol and xylitol at 48 h of fermentation.

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“…Rare sugar derivatives are used as effective antivirals, for example against hepatitis-B virus and human immunodeficiency virus, and antitumor agents [7, 8]. The demand for rare sugars has been rising recently; global production was in excess of 133 million tons in 2002.…”

Section: Introductionmentioning

confidence: 99%

Insilico Characterization and Homology Modeling of Arabitol Dehydrogenase (ArDH) from Candida albican

et al. 2013

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Background: Arabitol dehydrogenase (ArDH) is involved in the production of different sugar alcohols like arabitol, sorbitol, mannitol, erythritol and xylitol by using five carbon sugars as substrate. Arabinose, d-ribose, d-ribulose, xylose and d-xylulose are known substrate of this enzyme. ArDH is mainly produced by osmophilic fungi for the conversion of ribulose to arabitol under stress conditions. Recently this enzyme has been used by various industries for the production of pharmaceutically important sugar alcohols form cheap source than glucose. But the information at structure level as well as its binding energy analysis with different substrates was missing. Results: The present study was focused on sequence analysis, insilico characterization and substrate binding analysis of ArDH from a fungus specie candida albican. Sequence analysis and physicochemical properties showed that this protein is highly stable, negatively charged and having more hydrophilic regions, these properties made this enzyme to bind with number of five carbon sugars as substrate. The predicted 3D model will helpful for further structure based studies. Docking analysis provided free energies of binding of each substrate from a best pose as arabinose -9.8224calK/mol, dribose -11.3701Kcal/mol, d-ribulose -8.9230Kcal/mol, xylose -9.7007Kcal/mol and d-xylulose 9.7802Kcal/mol. Conclusion: Our study provided insight information of structure and interactions of ArDH with its substrate. These results obtained from this study clearly indicate that d-ribose is best substrate for ArDH for the production of sugar alcohols. This information will be helpful for better usage of this enzyme for hyper-production of sugar alcohols by different industries.

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Microbial and Bioconversion Production of D-xylitol and Its Detection and Application

Cited by 112 publications

References 83 publications

Xylitol production by yeasts isolated from rotting wood in the Galápagos Islands, Ecuador, and description of Cyberlindnera galapagoensis f.a., sp. nov.

Xylitol production by yeasts isolated from rotting wood in the Galápagos Islands, Ecuador, and description of Cyberlindnera galapagoensis f.a., sp. nov.

Bioconversion of hydrolyzed cashew peduncle bagasse for ethanol and xylitol production

Insilico Characterization and Homology Modeling of Arabitol Dehydrogenase (ArDH) from Candida albican

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