Microbial and host factors contribute to bloodstream infection in a pediatric acute lymphocytic leukemia mouse model

Song, Yajing; Perlman, Katherine; Gyarmati, Péter

doi:10.1016/j.heliyon.2022.e11340

Cited by 3 publications

(2 citation statements)

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“…Changes in the gut and fecal microbiome in a pediatric T-ALL mouse model, SCFA levels, and the gut barrier may lead to bacterial translocation and subsequent BSI. SCFAs supplementation was found to improve the effects of BSIs indicating that rational probiotic supplementation can help maintain the stability of the intestinal microenvironment and thus alleviate leukemia-induced BSI ( Song et al, 2022 ). Graft-versus-host disease (GVHD) is another common complication of leukemia treatment ( Choe and Ferrara, 2021 ).…”

Section: The Relationship Among Gut Microbes Probiotics and Leukemiamentioning

confidence: 99%

Advancements in the impact of human microbiota and probiotics on leukemia

Zhang,

Zhao,

Zhang

et al. 2024

Front. Microbiol.

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The human gut microbiota is a complex ecosystem that plays a crucial role in promoting the interaction between the body and its environment. It has been increasingly recognized that the gut microbiota has diverse physiological functions. Recent studies have shown a close association between the gut microbiota and the development of certain tumors, including leukemia. Leukemia is a malignant clonal disease characterized by the uncontrolled growth of one or more types of blood cells, which is the most common cancer in children. The imbalance of gut microbiota is linked to the pathological mechanisms of leukemia. Probiotics, which are beneficial microorganisms that help maintain the balance of the host microbiome, play a role in regulating gut microbiota. Probiotics have the potential to assist in the treatment of leukemia and improve the clinical prognosis of leukemia patients. This study reviews the relationship between gut microbiota, probiotics, and the progression of leukemia based on current research. In addition, utilizing zebrafish leukemia models in future studies might reveal the specific mechanisms of their interactions, thereby providing new insights into the clinical treatment of leukemia. In conclusion, further investigation is still needed to fully understand the accurate role of microbes in leukemia.

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Section: The Relationship Among Gut Microbes Probiotics and Leukemiamentioning

confidence: 99%

Advancements in the impact of human microbiota and probiotics on leukemia

Zhang,

Zhao,

Zhang

et al. 2024

Front. Microbiol.

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“…Finally, the microorganisms that colonize our bodies also produce metabolites through nutrient consumption that influence human health and have potential benefits when used as therapies (postbiotics). Short-chain fatty acids (SCFAs), the major byproducts of bacterial fermentation in the large intestine, were recently demonstrated to prevent bloodstream infection in a mouse model of pediatric acute lymphoblastic leukemia [45]. Moreover, lower abundances of SCFAs have previously been associated with severe illness among infants with RSV bronchiolitis; Antunes et al [46] recently demonstrated that treatment with the SCFA acetate reduced viral replication in RSV-infected human lung epithelial cells and improved recovery of RSV-infected mice.…”

Section: Development Of Microbiome-directed Therapiesmentioning

confidence: 99%

Host microbiome-pathogen interactions in pediatric infections

Hurst

Heston

Kelly

2023

Current Opinion in Infectious Diseases

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Purpose of review In this review, we discuss recent research that has furthered our understanding of microbiome development during childhood, the role of the microbiome in infections during this life stage, and emerging opportunities for microbiome-based therapies for infection prevention or treatment in children. Recent findings The microbiome is highly dynamic during childhood and shaped by a variety of host and environmental factors. In turn, the microbiome influences risk and severity of a broad range of infections during childhood, with recent studies highlighting potential roles in respiratory, gastrointestinal, and systemic infections. The microbiome exerts this influence through both direct interactions with potential pathogens and indirectly through modulation of host immune responses. The elucidation of some of these mechanisms by recent studies and the development of effective microbiome-based therapies for adults with recurrent Clostridioides difficile infection highlight the enormous promise that targeting the microbiome has for reducing the burden of infectious diseases during childhood. Summary The microbiome has emerged as a key modifier of infection susceptibility and severity among children. Further research is needed to define the roles of microbes other than bacteria and to elucidate the mechanisms underlying microbiome-host and microbiome-pathogen interactions of importance to infectious diseases in children.

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Prevention and Health Benefits of Prebiotics, Probiotics and Postbiotics in Acute Lymphoblastic Leukemia

et al. 2023

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Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children, comprising 75–85% of cases. Aggressive treatment of leukemias includes chemotherapy and antibiotics that often disrupt the host microbiota. Additionally, the gut microbiota may play a role in the development and progression of acute leukemia. Prebiotics, probiotics, and postbiotics are considered beneficial to health. The role of prebiotics in the treatment and development of leukemia is not well understood, but inulin can be potentially used in the treatment of leukemia. Some probiotic bacteria such as Lactobacillus shows anticancer activity in in vitro studies. Additionally, Bifidobacterium spp., as a consequence of the inhibition of growth factor signaling and mitochondrial-mediated apoptosis, decrease the proliferation of cancer cells. Many bacterial metabolites have promising anticancer potential. The available research results are promising. However, more research is needed in humans, especially in the child population, to fully understand the relationship between the gut microbiota and acute leukemia.

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Microbial and host factors contribute to bloodstream infection in a pediatric acute lymphocytic leukemia mouse model

Cited by 3 publications

References 61 publications

Advancements in the impact of human microbiota and probiotics on leukemia

Advancements in the impact of human microbiota and probiotics on leukemia

Host microbiome-pathogen interactions in pediatric infections

Prevention and Health Benefits of Prebiotics, Probiotics and Postbiotics in Acute Lymphoblastic Leukemia

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