Microbial Azurin Immobilized on Nano-Chitosan as Anticancer and Antibacterial Agent Against Gastrointestinal Cancers and Related Bacteria

Al-Hazmi, Nawal E.; Naguib, Deyala M.

doi:10.1007/s12029-021-00654-6

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…[206] [206] Azurin Azurin is mediated by direct contact with proteins or glycosylated proteins in the bacterial cell, resulting in protein activity disruption and eventual loss of bacterial membrane function. [51] [51]…”

Section: Ll-37 and Lactoferricinmentioning

confidence: 99%

“…investigated whether azurin, a promising anticancer drug derived from Pseudomonas aeruginosa ( P. aeruginosa ), could be immobilized on nano‐chitosan to boost its anticancer and antibacterial activities against gastrointestinal cancer and the bacteria that cause it. [ 51 ] The MIC values for free azurin and nano‐azurin against F. nucleatum were determined to be 9.3 and 5.0 µg mL −1 , respectively. The antibacterial process of azurin is mediated by direct contact with proteins or glycosylated proteins in the bacterial cell, resulting in protein activity disruption and eventual loss of bacterial membrane function.…”

Section: Organic Chemicalsmentioning

confidence: 99%

“…[ 46,47 ] The third part comprises organic chemicals, including photosensitizers (PSs), antimicrobial peptides (AMPs), and other compounds. [ 48‐51 ] The fourth part discusses the inhibitory effects of polymers against F. nucleatum and presents examples of using antibacterial polymers to suppress drug‐resistant CRC. [ 52–56 ] In the following section, inorganic‐organic hybrid materials for F. nucleatum killing will be presented.…”

Section: Introductionmentioning

confidence: 99%

“…[46,47] The third part comprises organic chemicals, including photosensitizers (PSs), antimicrobial peptides (AMPs), and other compounds. [48][49][50][51] The fourth part discusses the inhibitory effects of polymers against F. nucleatum S C H E M E  Cartoon depiction showing the proposed strategies based on natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic-organic hybrid materials, bacteriophages, probiotics, and vaccines for combating F. nucleatum and F. nucleatum biofilms.…”

mentioning

confidence: 99%

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Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Liu,

Yu,

Dong

et al. 2023

Exploration

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Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived from the oral cavity. This tumor‐resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, F. nucleatum can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non‐antibiotic approaches to eradicate F. nucleatum and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic‐organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat F. nucleatum and F. nucleatum biofilms. This review summarizes the latest advancements in anti‐F. nucleatum research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC.

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Section: Ll-37 and Lactoferricinmentioning

confidence: 99%

Section: Organic Chemicalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Liu,

Yu,

Dong

et al. 2023

Exploration

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“…The anticancer activity of dissociative cyanine dye and nanocyanine dye was evaluated against CLS-145 gastric cancer cells, AsPC-1 pancreatic cancer cells, HCT116 colon cancer cells, KYSE-410 esophageal cancer cells, and HepG2 liver cancer cells, and the antibacterial activity of these dyes against bacteria associated with gastrointestinal cancer biopsies, including Helicobacter pylori , Fusobacterium nucleatum, enterohemorrhagic Escherichia coli , Clostridium difficile , and Porphyromonas gingivalis, was also examined. The results demonstrated notable anticancer and antibacterial effects for both dissociative cyanine dye and nanocyanine dye, and the nanocyanine dye exhibiting superior activity in suppressing cancer growth and combating bacterial strains ( Al-Hazmi and Naguib, 2022 ). Furthermore, Li et al synthesized two novel polymer-drug conjugates, docetaxel-polyvinyl alcohol and docetaxel-chitosan, via alcoholysis reactions.…”

Section: The Exploration Of Nanocarriers In Chinese Patent Medicinementioning

confidence: 99%

Nanodrugs systems for therapy and diagnosis of esophageal cancer

Zhang

Yue

et al. 2023

Front. Bioeng. Biotechnol.

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With the increasing incidence of esophageal cancer, its diagnosis and treatment have become one of the key issues in medical research today. However, the current diagnostic and treatment methods face many unresolved issues, such as low accuracy of early diagnosis, painful treatment process for patients, and high recurrence rate after recovery. Therefore, new methods for the diagnosis and treatment of esophageal cancer need to be further explored, and the rapid development of nanomaterials has brought new ideas for solving this problem. Nanomaterials used as drugs or drug delivery systems possess several advantages, such as high drug capacity, adjustably specific targeting capability, and stable structure, which endow nanomaterials great application potential in cancer therapy. However, even though the nanomaterials have been widely used in cancer therapy, there are still few reviews on their application in esophageal cancer, and systematical overview and analysis are deficient. Herein, we overviewed the application of nanodrug systems in therapy and diagnosis of esophageal cancer and summarized some representative case of their application in diagnosis, chemotherapy, targeted drug, radiotherapy, immunity, surgery and new therapeutic method of esophageal cancer. In addition, the nanomaterials used for therapy of esophageal cancer complications, esophageal stenosis or obstruction and oesophagitis, are also listed here. Finally, the challenge and the future of nanomaterials used in cancer therapy were discussed.

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How to manage Helicobacter pylori infection beyond antibiotics: The bioengineering quest

Fonseca,

Chitas,

Parreira

et al. 2024

Applied Materials Today

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Microbial Azurin Immobilized on Nano-Chitosan as Anticancer and Antibacterial Agent Against Gastrointestinal Cancers and Related Bacteria

Cited by 8 publications

References 25 publications

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Nanodrugs systems for therapy and diagnosis of esophageal cancer

How to manage Helicobacter pylori infection beyond antibiotics: The bioengineering quest

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