Microbial bioconversion of ginsenosides in <i>Panax ginseng</i> and their improved bioactivities

Eom, Su Jin; Kim, Kee‐Tae; Paik, Hyun‐Dong

doi:10.1080/87559129.2018.1424183

Cited by 33 publications

(34 citation statements)

References 72 publications

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“…SSF is an attractive method for filamentous fungus cultivation because the solid substrates mimic the natural habitat of fungi, resulting in improved growth and secretion of a wide range of enzymes [42]. The conversion of enzymatic ginsenoside-to-CK is greatly affected by enzyme activities, and β-glucosidase activity is considered the key factor in the selection of strains to be used for biotransformation of ginsenosides to CK [43]. In this study, β-glucosidase was selected to evaluate the enzyme activity during SSF among other enzyme activities in Stereum hirsutum JE0512.…”

Section: Optimization Of Agro-industrial Substratesmentioning

confidence: 99%

Production of minor ginsenosides by combining Stereum hirsutum and cellulase

et al. 2021

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Minor ginsenosides (MGs) (include ginsenoside F2, Compound K, PPT, etc), which are generally not produced by ginseng plants naturally, are obtained by deglycosylation of major ginsenosides. However, the conventional processes used to produce deglycosylated ginsenosides focus on the use of intestinal microorganisms for transformation. In this study, an edible and medicinal mushroom Stereum hirsutum JE0512 was screened from 161 β-glucosidase-producing soil microorganisms sourced from wild ginseng using the plate coloration method. Furthermore, JE0512 was used for the production of CK from ginseng extracts (GE) in solid-state fermentation (SSF) using 20 g corn bran as substrate, 4 g GE, and 20% inoculation volume, and the results showed that the highest CK content was 29.13 mg/g. After combining S. hirsutum JE0512 with cellulase (Aspergillus niger), the MGs (F2, CK, and PPT) content increased from 1.66 to 130.79 mg/g in the final products. Our results indicate that the Stereum genus has the potential to biotransform GE into CK and the combination of S. hirsutum JE0512 and cellulase could pave the way for the production of MGs from GE.

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Section: Optimization Of Agro-industrial Substratesmentioning

confidence: 99%

Production of minor ginsenosides by combining Stereum hirsutum and cellulase

et al. 2021

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“…Topic B (Metabolite analysis) papers were related to the antioxidant effects of ginseng by analyzing the bioprocessing of saponins [82]. Few studies have reviewed microbial ginsenosides that can be used as special additives in the food and medicinal industry [83]. Several papers examined the genetic diversity (Topic C) of WSG populations.…”

Section: Studies On Wild-simulated Ginseng By Countrymentioning

confidence: 99%

Global Trends in Research on Wild-Simulated Ginseng: Quo Vadis?

Shin

Park

Lee

et al. 2021

Forests

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To the best of our knowledge, no study has systematically reviewed and analyzed the research trends of wild-simulated ginseng (WSG) used for food or medicinal purposes in many countries. WSG, a non-timber forest product, has been traditionally produced using agroforestry practices, and it has been consumed in various ways for a long time. WSG has a great demand in the market due to its medicinal effects, particularly in improving forest livelihoods and human health. Due to the significance of WSG, we conducted this research to explore the global research trends on WSG using systematic review methodology and keyword analysis. We used two international academic databases, the Web of Science and SCOPUS, to extract 115 peer-reviewed articles published from 1982 to 2020. The research subjects, target countries, and keywords were analyzed. Our results indicate four categories of WSG research subjects, namely growth conditions, components, effects on humans/animals, and the environment of WSG, and the case studies were mainly from the Republic of Korea, China, and the USA. Through topic modelling, research keywords were classified into five groups, namely medicinal effects, metabolite analysis, genetic diversity, cultivation conditions, and bioactive compounds. We observed that the research focus on WSG changed from the biological properties and cultivation conditions of WSG to the precise identification and characterization of bioactive metabolites of WSG. This change indicates an increased academic interest in the value-added utilization of WSG.

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“…Hence, biotransformation is a common method for ginsenoside transformation (Chen et al, 2021;Zhang et al, 2019). Many studies have focused on the production of rare ginsenosides by microbial enzyme (Eom et al, 2018;Fu, 2019).…”

Section: Introductionmentioning

confidence: 99%

Microbial bioconversion of ginsenosides in Panax ginseng and their improved bioactivities

Cited by 33 publications

References 72 publications

Production of minor ginsenosides by combining Stereum hirsutum and cellulase

Production of minor ginsenosides by combining Stereum hirsutum and cellulase

Global Trends in Research on Wild-Simulated Ginseng: Quo Vadis?

Simultaneous transformation of ginsenoside Rb1 into rare ginsenoside F2 and Compound K by the extracellular enzyme from Aspergillus Niger Wu-16

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