Microbial cells as biological factory for nanoparticle synthesis

Das, Bhabani Shankar; Das, Ankita; Mishra, Abhisek; Arakha, Manoranjan

doi:10.1007/s11706-021-0546-8

Cited by 12 publications

(14 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various reports have shown the antiviral activity of titanium dioxide (TiO 2 ) NPs functionalized by embedding DNA in them against MDCK cell lines infected with influenza A subtypes. Graphene NPs have also been reported as a potential antimicrobial candidate [14].…”

Section: Potential Nanomaterials For Treatment Of Microbial Diseasesmentioning

confidence: 99%

“…Attaching VLNPs with the appropriate antigens, they have the potential to trigger immune responses and also avoid any nuclear enzymatic degradation. Being small in size they can also penetrate and target cellular nuclei sites [14].…”

Section: Antimicrobial Nanovaccinementioning

confidence: 99%

“…Many functionalized nanomaterials have an intrinsic adjuvant property that enhances the immune response in a host. This property is highly beneficial for vaccine development for immune-compromised patients [14].…”

Section: Development Of Functionalized Nanovaccines To Tackle Viral M...mentioning

confidence: 99%

“…Both hydrophobic and hydrophilic drugs can be carried within the same nanovehicle, and also ensure their sequential release. Scientists have recently designed combinatorial NPs enclosing endogenous lipid squalene, an adenosineimmunomodulator, and α-tocopherol for developing nanotherapy against acute viral inflammation [14]. Additionally, a lipid-based nanocarrier enclosing lopinavir, ritonavir, and tenofovir have been fabricated to treat lymphatic drug insufficiency [14].…”

Section: Combinatorial Therapy: Loading Drugs-cocktail In a Single Na...mentioning

confidence: 99%

“…It has thus been crucial for various imaging techniques such as MRI and fluorescence microscopy. Thus, it can be aptly said that these MNPs have been revolutionizing fields of molecular biology through development of molecular sensors, innovative carrier agents, imaging techniques, therapeutic approach to gene therapy, biomarker identification, and targeting strategies [14].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Nanotheranostics and its role in diagnosis, treatment and prevention of COVID-19

2022

Self Cite

View full text Add to dashboard Cite

Microbe-related, especially viral-related pandemics have currently paralyzed the world and such pathogenesis is expected to rise in the upcoming years. Although tremendous efforts are being made to develop antiviral drugs, very limited progress has been made in this direction. The nanotheranostic approach can be a highly potential rescue to combat this pandemic. Nanoparticles (NPs) due to their high specificity and biofunctionalization ability could be utilized efficiently for prophylaxis, diagnosis and treatment against microbial infections. In this context, titanium oxide, silver, gold NPs, etc. have already been utilized against deadly viruses like influenza, Ebola, HIV, and HBV. The discovery of sophisticated nanovaccines is under investigation and of prime importance to induce reproducible and strong immune responses against difficult pathogens. This review focuses on highlighting the role of various nano-domain materials such as metallic NPs, magnetic NPs, and quantum dots in the biomedical applications to combat the deadly microbial infections. Further, it also discusses the nanovaccines those are already available for various microbial diseases or are in clinical trials. Finally, it gives a perspective on the various nanotechnologies presently employed for efficient diagnosis and therapy against disease causing microbial infections, and how advancement in this field can benefit the health sector remarkably.

show abstract

Section: Potential Nanomaterials For Treatment Of Microbial Diseasesmentioning

confidence: 99%

Section: Antimicrobial Nanovaccinementioning

confidence: 99%

Section: Development Of Functionalized Nanovaccines To Tackle Viral M...mentioning

confidence: 99%

Section: Combinatorial Therapy: Loading Drugs-cocktail In a Single Na...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nanotheranostics and its role in diagnosis, treatment and prevention of COVID-19

2022

Self Cite

View full text Add to dashboard Cite

show abstract

Photocatalytic activity of biosynthesized silver nanoparticle fosters oxidative stress at nanoparticle interface resulting in antimicrobial and cytotoxic activities

Sahoo

Rath

Champati

et al. 2023

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

Inside the biological milieu, nanoparticles with photocatalytic activity have potential to trigger cell death non‐specifically due to production of reactive oxygen species (ROS) upon reacting with biological entities. Silver nanoparticle (AgNP) possessing narrow band gap energy can exhibit high light absorption property and significant photocatalytic activity. This study intends to explore the effects of ROS generated due to photocatalytic activity of AgNP on antimicrobial and cytotoxic propensities. To this end, AgNP was synthesized using the principle of green chemistry from the peel extract of Punica granatum L., and was characterized using UV–Vis spectroscope, transmission electron microscope and x‐ray diffraction, and so forth. The antimicrobial activity of AgNP against studied bacteria indicated that, ROS generated at AgNP interface develop stress on bacterial membrane leading to bacterial cell death, whereas Alamar Blue dye reduction assay indicated that increased cytotoxic activity with increasing concentrations of AgNP. The γH2AX activity assay revealed that increasing the concentrations of AgNP increased DNA damaging activity. The results altogether demonstrated that both antimicrobial and cytotoxic propensities are triggered primarily due interfacial ROS generation by photocatalytic AgNP, which caused membrane deformation in bacteria and DNA damage in HT1080 cells resulting in cell death.

show abstract

Biogenic Synthesis of Silver Nanoparticle from Punica granatum L. and Evaluation of Its Antioxidant, Antimicrobial and Anti-biofilm Activity

Sahoo

Panigrahi²,

Das³

et al. 2022

J Inorg Organomet Polym

View full text Add to dashboard Cite

Microbial cells as biological factory for nanoparticle synthesis

Cited by 12 publications

References 125 publications

Nanotheranostics and its role in diagnosis, treatment and prevention of COVID-19

Nanotheranostics and its role in diagnosis, treatment and prevention of COVID-19

Photocatalytic activity of biosynthesized silver nanoparticle fosters oxidative stress at nanoparticle interface resulting in antimicrobial and cytotoxic activities

Biogenic Synthesis of Silver Nanoparticle from Punica granatum L. and Evaluation of Its Antioxidant, Antimicrobial and Anti-biofilm Activity

Contact Info

Product

Resources

About