Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort

Valkonen, Maria; Täubel, Martin; Pekkanen, Juha; Tischer, Christina; Rintala, Helena; Zock, Jan‐Paul; Casas, Lidia; Probst‐Hensch, Nicole; Forsberg, Bertil; Holm, Mathias; Janson, Christer; Pin, Isabelle; Gíslason, Þórarinn; Jarvis, Déborah; Heinrich, Joachim; Hyvärinen, Anne

doi:10.1111/ina.12427

Cited by 22 publications

(20 citation statements)

References 47 publications

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“…While the chemical components of PM pollution and their impacts on human health have been widely studied [9], the potential impact of pollutant-associated microbes remains unclear. Airborne microbial exposure, including exposure to dust-associated organisms, has been established to both protect against and exacerbate certain diseases [10][11][12]. Understanding the temporal dynamics of the taxonomic and functional diversity of microorganisms in urban air, especially during smog events, will improve our understanding of the potential microbe-associated health consequences.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal survey of microbiome associated with particulate matter in a megacity

Qin

Liang

Wu³

et al. 2020

Genome Biol

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Background: While the physical and chemical properties of airborne particulate matter (PM) have been extensively studied, their associated microbiome remains largely unexplored. Here, we performed a longitudinal metagenomic survey of 106 samples of airborne PM 2.5 and PM 10 in Beijing over a period of 6 months in 2012 and 2013, including those from several historically severe smog events.Results: We observed that the microbiome composition and functional potential were conserved between PM 2.5 and PM 10 , although considerable temporal variations existed. Among the airborne microorganisms, Propionibacterium acnes, Escherichia coli, Acinetobacter lwoffii, Lactobacillus amylovorus, and Lactobacillus reuteri dominated, along with several viral species. We further identified an extensive repertoire of genes involved in antibiotic resistance and detoxification, including transporters, transpeptidases, and thioredoxins. Sample stratification based on Air Quality Index (AQI) demonstrated that many microbial species, including those associated with human, dog, and mouse feces, exhibit AQI-dependent incidence dynamics. The phylogenetic and functional diversity of air microbiome is comparable to those of soil and water environments, as its composition likely derives from a wide variety of sources.Conclusions: Airborne particulate matter accommodates rich and dynamic microbial communities, including a range of microbial elements that are associated with potential health consequences.

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Section: Introductionmentioning

confidence: 99%

Longitudinal survey of microbiome associated with particulate matter in a megacity

Qin

Liang

Wu³

et al. 2020

Genome Biol

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“…TLR5 recognizes bacterial flagellin, which is an important virulence factor of many bacteria and is also found in house dust . The effect of bacterial products in house dust is mainly protective for allergy and asthma . In prior studies, activation of TLR5 by flagellin has been associated with atopic eczema and also with asthma, but there are studies with contradictory results reporting that asthmatic patients have decreased expression or impaired function of TLR5 .…”

Section: Introductionmentioning

confidence: 99%

TLR5 rs5744174 gene polymorphism is associated with the virus etiology of infant bronchiolitis but not with post‐bronchiolitis asthma

Törmänen

Teräsjärvi

Lauhkonen

et al. 2018

Health Science Reports

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Background and aim: Bronchiolitis is a leading cause of hospitalization in infants and is associated with a risk of subsequent asthma. The innate immunity genes, such as those encoding toll-like receptors (TLRs), are likely to play a role in bronchiolitis and post-bronchiolitis outcome. Thus far, only one study has considered TLR5 genes in respiratory syncytial virus (RSV) bronchiolitis. The aim of this study was to investigate the association of TLR5 gene polymorphism with virus etiology and severity of bronchiolitis, and with post-bronchiolitis asthma.Methods: We recruited 164 infants (age < 6 months) hospitalized for bronchiolitis in this study and determined TLR5 rs5744174 (C > T) single nucleotide polymorphism, virus etiology and severity markers of bronchiolitis, and presence of post-bronchiolitis asthma until age 11 to 13 years.Results: RSV was detected in 113 (68.9%), rhinovirus in 19 (11.6%), and some other virus in 20 (12.2%) cases. Non-RSV etiology was more common among infants with the variant CT or TT genotype in the TLR5 rs5744174 gene than in those with the CC genotype (89.7% vs 71.7%, P = 0.03). TLR5 rs5744174 polymorphism was not associated with the need of supplementary oxygen or feeding support, with the length of hospital stay, or with post-bronchiolitis asthma at any age. Conclusion:The TLR5 rs5744174 variant genotype may increase the susceptibility to bronchiolitis not caused by RSV. 2This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Muramic acid, which is the main component of the peptidoglycan layer of gram-positive bacteria, activates innate immunity through TLR-2 and participates in immune regulation. [ 20 ]…”

Section: The External Microbial Environment In Early Life Is Crucial mentioning

confidence: 99%

Microecology research: a new target for the prevention of asthma

Shi

Lan

et al. 2020

Chinese Medical Journal

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The incidence and prevalence of asthma have increased remarkably in recent years. There are lots of factors contributing to the occurrence and development of asthma. With the improvement of sequencing technology, it has been found that the microbiome plays an important role in the formation of asthma in early life. The roles of the microbial environment and human microbiome in the occurrence and development of asthma have attracted more and more attention. The environmental microbiome influences the occurrence of asthma by shaping the human microbiome. The specific mechanism may be related to the immune regulation of Toll-like receptors and T cells (special Tregs). Intestinal microbiome is formed and changed by regulating diet and lifestyle in early life, which may affect the development and maturation of the pulmonary immune system through the intestinal-pulmonary axis. It is well-recognized that both environmental microbiomes and human microbiomes can influence the onset of asthma. This review aims to summarize the recent advances in the research of microbiome, its relationship with asthma, and the possible mechanism of the microbiome in the occurrence and development of asthma. The research of the microbial environment and human microbiome may provide a new target for the prevention of asthma in children who have high-risk factors to allergy. However, further study of “when and how” to regulate microbiome is still needed.

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Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort

Cited by 22 publications

References 47 publications

Longitudinal survey of microbiome associated with particulate matter in a megacity

Longitudinal survey of microbiome associated with particulate matter in a megacity

TLR5 rs5744174 gene polymorphism is associated with the virus etiology of infant bronchiolitis but not with post‐bronchiolitis asthma

Microecology research: a new target for the prevention of asthma

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